Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Subjectively healthy HLA-B27 positive 1st degree relatives (n = 14) of patients with ankylosing spondylitis (AS) were investigated concerning the mass fraction of calcium (Ca), magnesium (Mg), manganese (Mn), iron (Fe), zinc (Zn), strontium (Sr) and copper (Cu) in isolated blood cells using the nuclear microprobe technique. No relative had laboratory signs of inflammatory disease defined by acute phase plasma proteins. An accumulation of Mg, Ca, Mn and Fe was found in granulocytes compared with healthy controls. In platelets there was an accumulation of Fe and a reduction of the Cu content. In erythrocytes Ca was accumulated and the levels of Mg, Mn and Cu were reduced compared with the controls. Five of the relatives had radiological signs of sacroiliitis and 1 of these had sacroiliac tenderness. Relatives with and without radiological sacroiliitis showed no differences in the cellular metal amounts. When the alterations were compared with those previously found in patients with AS, a striking similarity was noted, although the changes were quantitatively less pronounced. In contrast B27 negative 1st degree relatives (n = 11) had normal mineral amounts in their cells. However, it seems less likely that altered metal handling could play a primary role for the disease susceptibility linked to HLA-B27 since B27 positive healthy controls (n = 12) without AS in the family had normal cellular stores of the measured elements. Rather our findings indicate that redistribution of cellular metals is an extremely sensitive marker of an inflammatory process not evident by clinical symptoms or increase of acute phase plasma proteins.
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PMID:Redistribution of cellular mineral and trace element stores in HLA-B27 positive relatives of patients with ankylosing spondylitis--a marker of hidden inflammatory disease. 325 20

The mass fraction of calcium (Ca), magnesium (Mg), manganese (Mn), iron (Fe). zinc (Zn), strontium (Sr) and copper (Cu) in isolated granulocytes, erythrocytes and platelets was measured using the nuclear microprobe technique. The cellular profile of metal variation was conspiciously altered in patients (n = 29) with ankylosing spondylitis compared with the profile found in age and sex matched healthy controls. Ca was accumulated in erythrocytes and granulocytes but decreased in platelets (p less than 0.001). Mg was increased in granulocytes but appeared in reduced concentrations in platelets and erythrocytes (p less than 0.001). The cellular amounts of Mn was increased in granulocytes (p less than 0.001), normal in platelets (p greater than 0.05) and subnormal in erythrocytes (p less than 0.001). Zn was reduced in all 3 cell types (p less than 0.001). Fe accumulation was evident in granulocytes and platelets (p less than 0.001). Sr was only measurable in granulocytes from patients. Cu was below the detection limit in the different cell types isolated from patients, but appeared in measurable amounts in erythrocytes and platelets from controls. The granulocyte amounts of Ca, Mg, Mn and Sr were strongly related to the acute phase reaction. Negative correlations were found between erythrocyte Mg and Zn and the inflammatory activity. The patients had increased serum levels of Cu, normal levels of Ca, Mg and Sr and decreased levels of Zn, Fe and Mn. No relationship was found between the serum concentrations of these elements and their respective cellular stores, except for a weak negative correlation between granulocyte and serum Fe.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Redistribution of minerals and trace elements in chronic inflammation--a study on isolated blood cells from patients with ankylosing spondylitis. 362 34