Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three patients, all exhibiting symptoms before 15 years of age, were diagnosed as juvenile ankylosing spondylitis (JAS) by stigma of JAS. The families of these three patients--a total of fifteen first-degree relatives--had clinical, radiologic and laboratory examinations. All three patients and four family members (26%) had positive HLA-B27 and ankylosing spondylitis (AS). Five (33%) of these three family members had positive HLA-B27 but were asymptomatic; six members(40%) were HLA-B27 negative and symptom-free. A high positive rate of HLA-B27 was found among the patients (100%) and the family members (60%). The rheumatoid factor, antinuclear antibody, and anti-native DNA antibody were negative for all patients and family members. Significant elevation of IgG, IgA, and C3 were noted in the AS group. The CD3 cell was lower, and the ratio of CD4/CD8 was decreased in the AS group. Lympho-proliferative responses to phytomitogens (Con A, LPS and PHA) were also done in our study. There was no significant difference in Con A and LPS stimulation index among the AS group, symptom-free family members and normal controls.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Immunological study in three families of juvenile ankylosing spondylitis. 151 12

The pathogenesis of ankylosing spondylitis (AS) remains unknown, although previous studies have strongly suggested that it may result from immunological aberration. To further explore the pathogenetic mechanisms, in vitro syntheses of immunoglobulins and interleukin-2 (IL-2) by peripheral blood mononuclear cells (MNC), and the serum level of the interleukin-2 receptor (IL-2R) were studied in 35 patients with definite AS and in 28 healthy controls. MNC were cultivated in the presence of pokeweed mitogen (PWM) for seven days. Immunoglobulins in the supernatants were measured by rate nephelometer (Immunochemistry System Analyser II, Beckman.) In vitro synthesis of IL-2 was carried out by cultivating MNC in medium only; in medium containing physiological concentration of the male sex hormone i.e., testosterone 500 ng/dl and estradiol 2 ng/dl; and in medium containing physiological concentration of female sex hormone, i.e., testosterone 50 ng/dl and estradiol 20 ng/dl. IL-2 was quantitated using an IL-2-dependent cytotoxic T lymphoid cell line (CTLL). Serum IL-2R was measured using an IL-2R test kit (CELLFREE, T Cell Sciences, Cambridge, MA). The results showed: In vitro synthesis of IgG, IgA and IgM was significantly higher in AS than in controls; In vitro synthesis of IL-2 was significantly enhanced by testosterone in normal control, but not in AS; and Serum IL-2R was significantly elevated in patients with AS. These findings, viewed in conjunction with previous results here, lead to postulation that an inflammatory process, elicited in HLA-B27-positive males and caused by an infectious agent invading via the mucosa may both cause immunological abnormalities and provoke various symptoms and signs of AS.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1987 Feb
PMID:Elevated serum interleukin-2 receptor; increased in vitro immunoglobulin synthesis and lack of response to testosterone-enhanced in vitro interleukin-2 production in ankylosing spondylitis. 310 49

Because the etiology of IgA and IgG hyperimmunoglobulinemia in ankylosing spondylitis (AS) remains unknown, the cellular immune system has been further studied by measuring the lymphocyte and its subpopulations in peripheral bloods of 50 definite AS patients and 40 normal controls. The system's functions have also been assessed in terms of proliferative responses to phytomitogens (Con A, PHA and PWM) and autologous mixed lymphocyte reaction (AMLR). The following results were obtained: The number of lymphocytes, total T, active T, OKIa1, OKT3, OKT4 and OKT8 cells in peripheral bloods of AS patients decreased more significantly when compared to the normal controls. The ratio of OKT4/OKT8 also decreased. However, the number of OKT8 cells was normal in inactive stage. While the lymphocytes of AS responded hyperreactively to PWM (B-cell mitogen), the response to Con A (T-cell mitogen) was depressed significantly. AMLR was impaired in AS patients no matter whether monocytes or B cells were used as stimulators. The aforementioned changes were especially evident in the active stage and most of them returned to normal after the disease became quiescent. It is therefore concluded that the etiology of hyperreactivity of B-cells in AS may be caused by T-cell immune aberration as evidenced by depressed lymphoproliferative response to T-cell mitogen (Con A) and impaired AMLR and/or the hyperfunction of B-cells themselves.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1985 Feb
PMID:Lymphocyte aberrations in ankylosing spondylitis. 316 9

To explore the immunopathogenetic mechanisms of hypergammaglobulinemia in ankylosing spondylitis (AS), the functions of B cell, helper T (OKT4) cell and suppressor T (OKT8) cell were examined, by using the co-cultivation technique for in vitro immunoglobulin biosynthesis, in 7 patients with active AS, 7 with inactive AS and 14 normal controls. Circulating immune complexes (CIC) in those subjects were also measured by a solid phase C1q binding assay. After B, OKT4 and OKT8 cells were separated from the heparinized peripheral blood, coculture of these cells which were either from the same patient, the same normal control, or their combination was carried out. The in vitro synthesized immunoglobulins were measured by a rate nephelometer (Immuno-chemistry system, analyzer II). The results were: In patients with active AS, the amounts of IgG and IgA synthesized by co-cultured B and T4 cells from patients (p) and T8 from the normal (n) were significantly higher than those of the normal controls; In patients with inactive AS, the amounts of IgG and IgA produced by co-cultured Bp + T4p + T8n, Bp + T4n + T8n, Bn + T4n + T8p, and Bn + T4p + T8p were significantly higher than those for the respective normal controls; The CIC in active AS was elevated significantly over that in the normal controls. These results suggest that in patients of AS, B cells and helper T cells are hyperactive, while suppressor T cells are depressed. The abnormal function of lymphocytes may cause elevated concentrations of immunoglobulins and CIC in the serum.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1986 Feb
PMID:Abnormal in vitro immunoglobulin synthesis of lymphocytes and increased circulating immune complex in patients with ankylosing spondylitis. 381 53

In order to explore the alteration in immunological function in patients with ankylosing spondylitis (AS), serum concentrations of IgG, IgA, IgM, C3 and C4, and lymphocyte subpopulations defined by monoclonal antibodies (OKT series) were studied in 40 AS and 20 age-matched normals. The results showed that i) The IgG and IgA in AS patients were much higher than those in normals (p less than 0.001) and C3, C4 and IgM were also increased (p less than 0.01, less than 0.05, less than 0.05, respectively), ii) The percentage of B cells and OKT3 cells of AS patients were lower, but OKT8 and OKIa1 were higher than that of normals (p less than 0.05). When the AS patients were further divided into active group (22 cases) with c-reaction protein (CRP) higher than, or equal to 15 mg/l and inactive group (18 cases) with CRP less than 15 mg/l, it was found that the inactive group had decreased B cells (p less than 0.01) and OKT3 (p less than 0.05) as compared with normals. On the other hand, the active group had increased percentage of OKT8 than normal controls (p less than 0.05), and increased OKIa1 than both inactive group and normal controls (p less than 0.01), but OKT3 decreased than the normal (p less than 0.05). It is therefore concluded that the immunological aberration plays a role in the pathogenesis of AS.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1984 Feb
PMID:Immunological aberrations in ankylosing spondylitis patients. 674 92

Using the two-step microcytotoxicity test as recommended by NIH, U.S.A., 66 Chinese of definite ankylosing spondylitis (AS), 41 their first-degree relatives, and 43 normal Chinese received HLA analysis. The positive rates of HLA-B27 of these 3 groups were 95.5%, 56.1%, and 4.7% respectively. The results indicate: (i) The positive rate of HLA-B27 in patients with AS is significantly higher than their first-degree relatives, or the normal controls. (ii) The high positive rate of HLA-B27 in Chinese with AS is similar to those of other races.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1981 Mar
PMID:Histocompatibility profile in Chinese with ankylosing spondylitis. 726 99

The histocompatibility antigens were determined in 170 normal Chinese by a modified micro-lymphocytotoxicity test of Terasaki using 26 typing sera obtained from Behring Laboratories and Stanford University, and the data were compared with those obtained from 36 systemic lupus erythematosus, 30 rheumatoid arthritis, 17 ankylosing spondylitis as well as 45 leprosy patients. In normal individuals HLA-A2,A11 and A9 were dominant in locus A, the frequency were 42.35%, 41.76% and 32.35% respectively. HLA-Bw17, B13 and B5 were dominant in locus B, the frequency were 55.29%, 19.41% and 14.70% respectively. In systemic lupus erythematosus, the frequency of B8, Bw38 and A3 were slightly higher than normal (relative risk > 2); the frequency of Bw21 and B7 were little lower (risk of Bw21 < 0.5, frequency of B7 > 5% in normals but none in patients). In rheumatoid arthritis, the frequency of A28 and A10 (Aw25+26) were slightly lower than normal (risk < 0.5). In ankylosing spondylitis, the frequency of B27 was extremely high (risk = 44.92), Aw24 was also rather high (risk > 2); the frequency of B5, Bw35 and A10 (Aw25+26) was low (risk < 0.5), Bw15 and Bw21 > 5% in normals but none in patients. In leprosy, the frequency of B18 was relatively high (risk > 2); A3, Aw30+31+32, B27 and Bw35 were somewhat low (risk < 0.5). Because of the small sample size, however, the differences were not significant by Chi square analysis except the high frequency of B27 in ankylosing spondylitis (corrected P < 0.001).
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1980 Mar
PMID:[Tissue typing of blood lymphocytes in normal Chinese and diseases (author's transl)]. 744 26