Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Benoxaprofen (600 mg once daily) has been compared to indomethacin (25 mg 3 times daily) in a double-blind crossover study of 20 patients with active ankylosing spondylitis (AS). The clinical improvement was comparable with both drugs; 6 patients preferred benoxaprofen and 7 patients indomethacin. Although 2 patients discontinued benoxaprofen because of lack of effect, no upper gastrointestinal side effects were reported with this drug. Benoxaprofen is an alternative to indomethacin in the treatment of AS.
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PMID:A comparative study of benoxaprofen and indomethacin in ankylosing spondylitis. 699 70

Benoxaprofen is a nonsteroidal anti-inflammatory agent with a novel spectrum of pharmacological activity including regulatory effects on monocytes. It significantly reduces the serum alkaline phosphatase in patients with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The reduction usually has been within the normal range, but sometimes there has been a change from an abnormal to a normal value. The possible significance of this observation and ways of examining it further are discussed in this review. The reduction may be an effect on osteoblasts secondary to an effect on osteoclasts, cells known to be derived from monocyte precursors. If so, benoxaprofen should be effective in Paget's disease of the bone and preliminary data suggest this may be so.
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PMID:Benoxaprofen and its effect on serum alkaline phosphatase: a review. 704 96

Benoxaprofen, 600 mg once daily, was compared with ketoprofen, 100 mg twice daily, in a double-blind parallel study of 23 patients with definite active ankylosing spondylitis. Results were assessed using the following measurements: day pain, night pain, and spinal stiffness. Spinal stiffness was determined by means of standard clinical tests. Patient's evaluation and physician's overall assessment at the end of therapy also were taken into account. Under these conditions, the therapeutic response for benoxaprofen was good/very good, 8; fair, 2; and no response, 2. For ketoprofen, the response as good/very good, 5; fair 3; and no response 3. This study shows that benoxaprofen provides very good therapeutic effectiveness in the treatment of ankylosing spondylitis. This is confirmed by the absence of any statistically significant difference between the results observed with benoxaprofen and with ketoprofen, a drug known to be of value in ankylosing spondylitis. The clinical and biologic tolerance of benoxaprofen in this study was quite satisfactory.
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PMID:A comparative study of benoxaprofen and ketoprofen in ankylosing spondylitis. 704 3