Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the management of rheumatic diseases, the use of corticosteroids should be reserved for active arthritis. Phenylbutazone (Butazolidin) is probably the drug of choice for acute gout and is also effective in ankylosing spondylitis, Reiter's syndrome, and psoriatic arthritis. Indomethacin (Indocin) also is useful in these conditions. Ibuprofen (Motrin) is only slightly more efficacious than aspirin. Aspirin is still the preferred treatment for rheumatoid arthritis and should be tried before ibuprofen. Osteoarthritis of the cervical or lumbar spine calls for a full program of physical therapy. Experimental procedures for total replacement of joints other than hip and knee show promise.
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PMID:Rheumatic diseases. 2. Therapeutic considerations. 108 14

Fenoprofen, 600 mg, three times daily, was compared with phenylbutazone, 100 mg, three times daily, in 30 patients suffering from ankylosing spondylitis in a double-blind cross-over study. Assessments were made after an initial washout period and after each month-long treatment period. Phenylbutazone significantly improved morning stiffness, finger-to-floor distance, chest expansion, overall joint pain, spinal pain, the physician's assessment of disease activity and ESR. Only chest expansion was significantly improved by fenoprofen, and phenylbutazone was significantly better than fenoprofen in its effects on finger-to-floor distance, morning stiffness, overall joint pain, spinal pain and the physician's assessment of disease activity. Side-effects were of a minor nature apart from one patient who developed rectal bleeding on phenylbutazone which recurred on rechallenging.
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PMID:A double-blind cross-over trial of fenoprofen and phenylbutazone in ankylosing spondylitis. 701 May 12

In a double lind test 60 patients with ankylosing spondylitis received either Azapropazone (30 patients) or Indomethacin (30 patients) during a period of three weeks. In the two well comparable groups the therapeutic effect was equally good. As the results show the Azapropazone group came out a little better concerning the finger-ground distance and the difference in circumference of thorax, and the Azapropazone group was favoured slightly by the general judgement of the patients. However, these differences are not relevant. The influence on the spontaneous pain in the daytime and during the night and the shifting of dorsal and lumbar vertebral column was equally good in both groups. The compatibility was good in 59 out of 60 patients. One patient had to stop the Azapropazone medication because of gastric trouble in the second week of treatment. This result shows that in most patients an adequate medication with Azapropazone or with Indomethacin leads to a distinct reduction of pain and even painlessness already after a 3 weeks' treatment. This is particularly important regarding kinesiatrics. Indomethacin and Phenylbutazone are generally regarded as approved preparations in treatment of ankylosing spondylitis. If Azapropazone which, according to all previous reports has no hematotoxic effect like Phenylbutazone, had the same good effect in a double blind test as Indomethacin, this must be regarded as a very positive result. Concerning the good compatibility of Azapropazone, a change of drug is possible without a reduction of the effect.
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PMID:[Azapropazone versus indomethacin in a double blind test with patients with ankylosing spondylitis]. 728 5