Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Auranofin has no influence on axial skeleton manifestation of ankylosing spondylitis, neither on clinical complaints, nor on function and inflammatory parameters. Peripheral arthritis is possibly influenced positively, but this cannot be stated definitely because of the low number of cases in this study. This question must be analyzed in larger collectives, as alternatives to conventional therapy are needed for the treatment of peripheral joint involvement of ankylosing spondylitis.
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PMID:[The treatment of ankylosing spondylitis with auranofin (Ridaura)]. 219 Apr 36

Auranofin is the first oral gold therapy known to be effective at relatively low toxicities. Extensive clinical trials in rheumatoid arthritis have recently been complemented by first experiences in juvenile chronic polyarthritis. For the time being, the drug should, therefore, be confined to these conditions. It is not indicated in ankylosing spondylitis and in other seronegative arthropathies. Indications mainly include failure of antimalarials, early erosive arthropathies and contraindication of injection therapy. The drug may also be used as an alternative to intramuscular gold, but should not be administered to responders to other chronic antirheumatics and in late or end-stage disease.
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PMID:[Experiences to date with oral gold therapy]. 644 52