Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have studied the nerves of the synovium and capsules of 6 hips with ankylosing spondylitis, 6 hips with rheumatoid arthritis and 14 cases of coxarthrosis either primary or secondary to a malformation. The nerves were studied with the usual methods of peripheral neuropathology. In the various diseases except 5 cases of coxarthrosis secondary to a malformation, the inflammatory and vascular involvements with tissue fibrosis were able to affect the nerves crossing the tissues. This nerve involvement could be the cause of articular pain. Despite the importance of the surrounding lesions, the nerves are preserved for a long time and this could explain the persistance of the pain.
Rev Rhum Mal Osteoartic 1980 Jan
PMID:[Lesions of the nerves of the hip involving chronic rheumatic infections (ankylosing spondylitis, rheumatoid arthritis, arthrosis). Anatomopathologic study]. 738 16

A study of cell immunity was carried out in 23 patients with ankylosing spondylitis, 17 HLA B27 +, 6 HLA B27 --, 5 donors of normal blood carrying HLA B27 antigen and 50 controls, 7 methods were used together for a study of the markers of the blood lymphocyte membranes: rosette E, rapid rosette E, anti HTLA + X, surface immunoglobulins, PEA gamma and BEA gamma rosettes, determination of the monocytes after peroxidase staining. Stimulation of lymphocytes with mitogens (PHA, Con A, PWM) were carried out. There exists an increase in blood lymphocytes carrying HTLA + X in patients with ankylosing spondylitis HLA B27 and also in healthy carriers of the same antigen. During ankylosing spondylitis with HLA B27 --, a statistically significant reduction in T lymphocytes forming E and E rapid rosettes was observed; finally, a rise in the levels of circulating immune complexes detected by the PEG --C4 method was noted. The significance of these facts is discussed.
Rev Rhum Mal Osteoartic 1980 Jun
PMID:[Cellular immunity during ankylosing spondylitis]. 745 98

Mal-rotation of pelvis on the sagittal plane, which is common in patients with fixed spinal kyhposis, for example, ankylosing spondylitis, can cause error in cup positioning when hip arthroplasty is performed. The present study was performed to quantify the effects of sagittal pelvic mal-rotation on the final cup position and to evaluate different methods of cup positioning to compensate for the mal-rotation. Three-dimensional reconstruction of computer tomograms of 15 sets of full pelvi was performed. Two methods of cup insertion were simulated and compared: a method mimicking genuine surgery (anatomical positioning) and one that compensates for the sagittal pelvic mal-rotation (functional positioning). Sagittal pelvic mal-rotation of more than 20 degrees , if ignored, resulted in a cup with an anterversion of more than 30 degrees and an inclination of more than 55 degrees. Half of the cup surface was not in contact with host bone when the cup position was maintained at 20 degrees anteversion and 45 degrees inclination in a patient with 50 degrees sagittal pelvic mal-rotation. The usual method of cup positioning may need to be modified in patients with sagittal pelvic mal-rotation in order to maintain the desired cup position. For each 10 degrees of sagittal pelvic mal-rotation beyond 20 degrees of mal-rotation, the cup needs to be put in such that it is 5 degrees less inclined and anteverted.
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PMID:Sagittal pelvic mal-rotation and positioning of the acetabular component in total hip arthroplasty: Three-dimensional computer model analysis. 1734 79

Recent studies published on the genetic basis of ankylosing spondylitis (AS) reflect novel areas of investigation and extension of recent advances. As HLA-B27 subtypes have been extensively examined in other ethnic groups, novel insights into the relevance of HLA-B27 folding to disease susceptibility have led to questions regarding the influence of HLA-B27 on AS pathogenesis. The recent identification of IL23R, ERAP1, and interleukin-1 (IL1A) region genes in AS pathogenesis has led to a number of replication studies. Other genes with inconsistent AS associations (eg, KIR, TLR4, ANKH, and TNAP) have been further examined with inconsistent results. Potential candidate genes (TIRAP, COL1A6, and MEFV) have been examined with no associations found. Tremendous progress has been made with respect to understanding the genetic basis of AS. The identification of new genes-ARTS1, IL23R, and IL1A-substantiate that susceptibility to AS is also determined by genes outside the MHC.
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PMID:Recent studies on the genetic basis of ankylosing spondylitis. 1977 29


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