Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Microsomal epoxide hydrolase catalyses the hydrolysis of epoxides to water-soluble trans-dihydrodiols. We studied the expression of the hydrolase in synovial tissue samples from patients with osteoarthritis (n = 20), rheumatoid arthritis (n = 36), ankylosing spondylitis (n = 10) or psoriatic arthritis (n = 15) by use of immunohistochemistry with videodensitometric quantification of staining. Strong immunostaining for microsomal epoxide hydrolase was detected in tunica media of synovial blood vessels and moderate staining in synovial lining cells. Experiments with antibodies against CD68 and CLA suggested that both type A (macrophage-like) and type B lining cells (fibroblast-like synoviocytes) express the hydrolase. In addition, some of the subsynovial fibroblast-like cells, histiocytes and monocytes were intensively stained for microsomal epoxide hydrolase. In general, there were no major differences in the intensity of immunostaining for the hydrolase between the diagnostic groups. The enzyme may be involved in local hydrolysis of epoxide metabolites of endo- and xenobiotics in synovial tissue.
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PMID:Immunohistochemical detection of microsomal epoxide hydrolase in human synovial tissue. 1057 13

The objective of the study was to investigate the association between IL-8 and other biomarkers of endothelial dysfunction (MCP-1, V-CAM, I-CAM) and the disease activity scores in a sample of 54 patients with ankylosing spondylitis (AS) without use of biological agents. Fifty-four AS patients without treatment with anti-TNFs agents between 18 and 80 years old, who met modified New York criteria and at the same time the axial ASAS criteria, were evaluated using an epidemiological questionnaire that included among others clinical data, BASDAI, BASFI, ASQoL, ASDAS and plasma levels of CRP, ESR, MCP-1, IL-8, ICAM-1 and VCAM-1. IL-8 varied in proportion to disease activity rates (BASDAI and ASDAS) p < 0.05, being strongly correlated with the disease activity. The levels of adhesion molecules I-CAM and VCAM, as described in other studies, were positively correlated with predisposing factors for cardiovascular disease. IL-8 has shown to be strongly correlated with clinical markers of disease activity and inflammatory activity and may be an additional variable to the overall assessment of the activity of the AS.
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PMID:IL-8 but not other biomarkers of endothelial damage is associated with disease activity in patients with ankylosing spondylitis without treatment with anti-TNF agents. 2329 14