Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aortic valve disease of autoimmune disease is complicated in pre-, peri- and post-operative care. Recommended care in aortitis, ankylosing spondylitis, systemic lupus erythematosus and rheumatoid arthritis were described. Surgical strategy should be determined depending on basic disease, degree of inflammation and region of disease. Because of the fragile tissue of autoimmune disease patient, modified Bentall procedure is recommended to prevent a prosthetic valve dropping off for aortitis. Perioperatively, it is important to control the inflammation of basic disease, thus a steroid cover is necessary perioperatively. Some complications such as infection, out-of-control of anti-coaguration or gastro-intestinal bleeding should be avoided. Post operation, a strict follow up of prosthetic valve and aorta around suture line and control of autoimmune disease should be achieved.
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PMID:[Aortic valve surgery for autoimmune disease]. 2286 21

Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. The authors present the case of a 22-year-old female patient that was admitted to their hospital due to diarrhea, fever, arthralgias, and diffuse erythematous papules and plaques with vesicles and pustules affecting the patient's face, lips, arms, trunk, and legs. Six months prior to onset, the patient was diagnosed with terminal ileitis and Crohn's disease of the sigmoid colon. Treatment with mesalazine and budesonide had been introduced. In the diagnostic procedure, a skin biopsy was taken from the patient. Histology confirmed dense infiltration of neutrophilic polymorphonuclear leukocytes, or Sweet's syndrome. This condition is a rare manifestation of chronic inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. This syndrome is thought to be a hypersensitivity reaction and may be associated with various inflammatory, infectious, or neoplastic diseases. The patient was treated with high doses of methylprednisolone (60 mg IV), which resulted in rapid improvement of Crohn's disease and skin lesions.
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PMID:Acute febrile neutrophilic dermatosis in a patient with Crohn's disease: case report and review of the literature. 3024 70