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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The key to successful therapy for patients with ankylosing spondylitis is a lifelong, carefully devised, and well-instructed exercise program. This program is designed to maintain maximum range of motion within the spine, and the costovertebral and girdle joints, thereby preventing the tendency to flexion contractures and loss of height. The exercise program frequency requires long-term concomitant therapy with nonsteroidal anti-inflammatory drugs, partly to relieve the painful perispinal muscle spasm which frequently inhibits the exercise movements. The drugs are not known to alter the natural history of the inflammatory lesion. Local measures directed at ocular, urethral, and mucocutaneous inflammation may be symptomatically beneficial. These simple therapeutic principles ensure a good functional prognosis in the vast majority of patients with spondylitis.
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PMID:Therapy of the spondyloarthropathies. 11 95

Neck pain often occurs in the absence of neurologic findings, and the diagnostic dilemma of the clinician is to determine if there is a definable lesion. Radiographically, the cervical spine is commonly involved, especially in persons older than 50 years. Excluding soft-tissue inflammation and spasm, osteoarthritis is the most common rheumatic disease of the cervical spine. Radiculopathy and myelopathic involvement from disk, foraminal, or spinal canal impingement are all sequelae of this disease. Other diseases, such as DISH, rheumatoid arthritis, and ankylosing spondylitis, can affect the spine as well. Assessment of the integrity of the atlantoaxial joint is important in avoiding neurologic compromise.
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PMID:Arthritis of the cervical spine. 807

Back pain is a relatively common presenting symptom in children and adolescents. Typical causes include muscle strain or spasm, spinal deformities (e.g., Scheuermann kyphosis, adolescent idiopathic scoliosis), spondylolysis, bulging or herniated intervertebral disks, apophysitis of the iliac crest, and functional pain syndromes such as fibromyalgia. Spondyloarthropathies such as ankylosing spondylitis may present with low back pain and stiffness, which are often worse in the morning. Less common but more serious causes include malignancy and infections. The physical examination should include postural inspection, evaluation for tenderness, range of motion, strength testing, and testing for fractures and nerve impingement. Treatment for patients with muscle strain include relative rest, home-based exercises, physical therapy, and limited use of nonsteroidal anti-inflammatory drugs. If findings from the history and physical examination suggest underlying pathology, radiography and laboratory studies are indicated initially; magnetic resonance imaging, computed tomography, or a bone scan may be needed for further evaluation. It is generally accepted that the following factors warrant immediate evaluation: patient age younger than five years, symptoms persisting beyond four weeks, systemic symptoms, nighttime pain, bowel incontinence/urinary retention, or other neurologic symptoms.
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PMID:Back Pain in Children and Adolescents. 3260 67