Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A double-blind crossover trial of fenclofenac was untertaken to compare the short-term effects of phenylbutazone (Butacote) therapy with fenclofenac therapy (1200 mg daily) in 23 patients suffering from ankylosing spondylitis. The patients were randomly allocated to each of the test drugs for a period of two weeks, following wash-out periods of paracetamol for four days. The results favoured Butacote therapy in a dosage of 300 mg daily in the expressed preferences of both the patients and the physicians conducting the trial. Butacote was also better tolerated, as no severe side-effects occurred during treatment, whereas five patients developed a widespread rash during the period of fenclofenac therapy. No significant differences were seen between the two drugs in terms of clinical measurements of pain, morning stiffness, spinal movements, chest expansion, and abduction of the hips. Butacote was shown to cause some significant depletion of haemoglobin level, probably due to water retention, and Butacote also reduced the serum urate level to a significant degree.
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PMID:A controlled comparative trial of Butacote and fenclofenac in the treatment of ankylosing spondylitis. 33 11

A comparative controlled study was carried out in 40 patients suffering from rheumatoid arthritis, osteoarthrosis or ankylosing spondylitis to assess the efficacy of ketoprofen and ibuprofen. Patients were allocated at random to receive either 100 mg ketoprofen twice daily or 400 mg ibuprofen 3-times daily over a period of 3 months. Subjective overall assessments of symptoms, based on rating scale scores for pain, duration of morning stiffness and inflammation, showed that there was a greater, more rapid and more sustained improvement in those patients treated with ketoprofen. Measurements of inflamed joint size and of grip strength also improved more with ketoprofen than with ibuprofen. Side-effects, notably nausea, epigastric discomfort and abdominal pain, were more frequent and severe with ketoprofen, leading to the withdrawal of 2 patients in the early stage of the trial, and were probably related to the high dosage used. Three patients receiving ibuprofen needed 7 injections of ACTH to control their symptoms.
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PMID:A comparative trial of ketoprofen and ibuprofen in patients with rheumatic disease. 35 May

The effect and tolerance of proquazone and indomethacin in patients suffering from ankylosing spondylitis were compared in two separate 3-week clinical, double-blind, randomized studies on total of 60 patients. In the first study 16 patients were treated with proquazone and 14 patients with indomethacin, and in the second study 15 patients were treated in each group. Both drugs were found to have an evident, equally strong effect on pain and functional capacity in daily doses of 900 mg and 75mg respectively. Severe side effects were not noted with either one of the drugs. Patients with previously known intolerance to indomethacin were excluded from the studies. Gastronitestinal disturbances seem to be the most commonly appearing side effect in patients treated with proquazone.
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PMID:Proquazone (Biarison) and indomethacin (Indocid) in the treatment of ankylosing spondylitis. Two comparative, clinical, double-blind studies. 35 41

Naproxen is a propionic acid derivative with analgesic and anti-inflammatory activity which has been widely used in the treatment of rheumatic diseases. Naproxen has been well studied in rheumatoid arthritis and is as effective as aspirin but better tolerated, thus enabling more patients to continue with treatment. For this reason some clinicians now prefer to try propionic acid derivatives, such as naproxen, before aspirin in arthritic patients. In comparative studies with other non-steroidal anti-inflammatory drugs, such as indomethacin, ibuprofen, fenoprofen and others, all drugs were usually of similar overall efficacy although naproxen was sometimes preferred: but as with other non-steroidal anti-inflammatory agents, not all patients will respond to naproxen and in such cases other agents should also be tried until the most satisfactory drug is found for each patient. Naproxen is also effective in degenerative joint diseases of the hip and knee, although further well designed studies are needed to more clearly define its relative place compared with newer drugs such as diclofenac or diflunisal. Results of other comparative studies have shown that naproxen is a suitable alternative to phenylbutazone or indomethacin in ankylosing spondylitis and to aspirin in juvenile rheumatoid arthritis. Naproxen appears to be effective in reducing pain and swelling in acute gout and is an effective analgesic in patients with pain following surgery or trauma and in pain of dysmenorrhoea. Naproxen has generally been better tolerated than aspirin or indomethacin at the dosages used. Because of its relatively long plasma half-life, naproxen can with convenieice be given twice daily, and there is some evidence that once daily dosage is as effective in rheumatoid arthritis.
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PMID:Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states. 38 72

Fractures through the disc or juxta-end plate region of the vertebra as well as the posterior elements have been observed in the thoracic and lumbar spine in ankylosing spondylitis. These are usually associated with increasing pain, usually do not produce neurologic deficit, and may require orthopedic fixation to heal. Irregularity and sclerosis at the margins secondary to pseudarthrosis may develop and should not be confused with a pyogenic or granulomatous infection. Biomechanically these fractures resemble the "seat belt type" or Chance fracture probably because of shifting of the axis of flexion and extension in the ankylosed spine away from its normal location in the center of the nucleus pulposus.
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PMID:Fractures of the thoracolumbar spine in ankylosing spondylitis. 41 55

Radiological sacroiliac (SI) changes were found in 3 patients, 2 with primary hyperparathyroidism (1 also with associated chondrocalcinosis) and 1 with osteomalacia. Osteomalacia was due to celiac disease. None of the 3 patients, all females, had a history of psoriasis, urethritis, iritis or chronic colitis. There was no renal function impairment. Peripheral joints were affected in the patient with associated condrocalcinosis. HLA B 27 was negative in all cases. Low back pain and vertebral stiffness were present in the patient with osteomalacia. A dramatic improvement in pain and stiffness ensued after vitamin D injections. These SI lesions, which may simulate ankylosing spondylitis, were attributable to subchondral bone changes related to the metabolic bone diseases. In the case of osteomalacia the SI lesions were predominantly on the right side, where there was a Looser's zone on the ischial ramus suggesting that pseudofractures could be a cause of SI changes. Metabolic osseous diseases such as osteomalacia or primary hyperparathyroidism should be investigated in cases of HLA B 27 negative radiological "sacroiliitis".
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PMID:[Sacroiliac changes, HLA-B27 negative, in primary hyperparathyroidism and osteomalacia]. 46 71

Epidemiologic, clinical, radiologic and serologic evidence suggests that psoriatic arthritis is a specific entity and not the coincidental occurrence of 2 common diseases, psoriasis and rheumatoid arthritis. Psoriatic arthritis may be defined as psoriasis associated with inflammatory arthritis (peripheral arthritis or spondylitis or both) and usually a negative serologic test for rheumatoid factor. Clinical characteristics of the disease include: almost equal distribution between males and females; peripheral arthritis involving only a few small joints in asymmetical fashion; involvement of distal interphalangeal joints; sausage digits; arthritis mutilans; ankylosing spondylitis; goutlike onset; and higher frequency of nail involvement than occurs in uncomplicated psoriasis. The rash may present with arthritis, or, equally, may precede or succeed joint involvement. With regard to pain and disability, the prognosis in psoriatic arthritis is better than in rheumatoid arthritis.
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PMID:The clinical spectrum of psoriatic arthritis. 50 38

Twenty-six patients with ankylosing spondylitis and 10 control subjects had quantitative dorso-lumbar and sacroiliac scintigraphy performed using 99mtechnetium methylene diphosphonate. No difference was found in the mean uptakes of radionucleide at each vertebral level or in the sacroiliac joints between the diseases patients and controls. No correlation was found between radionucleide uptake and radiological score, pain and tenderness assessments. The large variation in quantiative measurements resulted in a large overlap between control and diseased patients and it is unlikely that scintigraphy will be of diagnostic value in the absence of improved methodology.
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PMID:Scintiscanning in ankylosing spondylitis: a clinical, radiological and quantitative radioisotopic study. 52 92

The clinical features of ankylosing spondylitis (AS) were compared in 63 HLA-B 27 positive (+) and 15 B27 negative (-) individuals with this disease. There were no differences in age at onset, functional class, degree of deformity, pain, severity of X-ray changes, or frequency of peripheral joint involvement or of reconstructive orthopedic surgery. These data demonstrated that skeletal manifestations of AS were essentially the same in B27(+) and (-) patients, and provide no evidence for the speculation that AS in B27(-) patients is milder or is a different disease from that occurring in B27(+) patients. On the other hand, acute anterior uveitis was found to be significantly more common in B27(+) patients, a fact suggesting that the "uveitis of AS" may in fact be an independent condition occurring in B27(+) individuals, rather than a manifestation of AS per se.
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PMID:Comparison of clinical features in HLA-B27 positive and negative patients with ankylosing spondylitis. 55 64

Eighteen total hip replacements were performed in 10 patients with ankylosing spondylitis. The mean observation time was 3.8 years. Seven hips had been operated on before total hip replacement (THR); 6 Were ankylotic before THR. The results as regards pain relief and increased walking distance were good. All hips improved in mobility after THR and this improvement was maintained during the observation time. Six of the 10 patients went back to full-time work. The differences between patients with ankylosing spondylitis and rheumatoid arthritis, as regards indications for and rehabilitation after THR, are discussed.
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PMID:Total hip replacement in ankylosing spondylitis. 59 46


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