Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quantitative sacroiliac scintigraphy was performed in 33 patients with ankylosing spondylitis (AS), 34 patients with nonspecific low back pain, and 30 control subjects. Significantly increased uptakes over the sacroiliac joints (SIJ) were found in patients with AS and in patients with degenerative changes of the SIJ. No significant differences were found between patients with mechanical low back pain by lumbar strain or by degenerative changes of the lumbar spine and the control subjects. But there were 2 of 13 patients with low back pain by lumbar strain with pathologic uptakes over the ISG. Since the scintigraphic technique is not specific, it is necessary to compare the scintigraphic results with clinical and radiological findings in each patient. On this condition sacroiliac scintigraphy is useful in early diagnosis of AS.
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PMID:[Value of scintigraphy for the early diagnosis of spondylitis ankylosans]. 731 67

Two (7%) out of 29 patients with chronic prostatis were HLA B27 positive. They had roentgenological normal sacro-iliac joints. Two (7%) had sacro-iliitis as judged by radiological examination; one of them had never experienced low back pain. No patient had arthropathy in peripheral joints, ulcerative colitis, Crohn's disease, psoriasis or anterior uveitis. It was concluded that ankylosing spondylitis is rare in patients treated for chronic prostatitis.
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PMID:HLA antigens and sacro-iliitis in chronic prostatitis. 745 19

Hard, objective data to evaluate outcome in patients with rheumatology diseases is not only difficult to obtain, but often poorly correlated with the degree of the functional incapacity caused by these non-fatal but disabilitating diseases. Soft, subjective data does not meet the traditional criteria for scientific research. However, due to important advances in the field of psychometry and its medical applications, we now have adequate instruments to evaluate quality of life, the major outcome parameter in patients with chronic rheumatic diseases. The Arthritis Impact Measurement Scales is the most widely used and is particularly adapted to patients with rheumatoid arthritis. Other scales include the Health Assessment Questionnaire, the Nottingham Health Profile, and the Sickness Impact Profile. Most of the studies conducted in the field of rheumatology concern patients with rheumatoid arthritis or osteoarthritis of the lower limbs. Quality of life measures can however be applied to most all the different clinical situations including low back pain, ankylosing spondylitis and systemic diseases. Quality of life measures will play an important role in treatment evaluation procedures. They correspond to real progress in responding to the legitimate demand of patient with chronic diseases for effective validated health care.
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PMID:[Measurement of quality of life in rheumatic practice]. 798 38

Cases of half sister and brother with ankylosing spondylitis (AS) in whom drug therapy with salazosulfapyridine (SASP) showed excellent effect were reported. A 31 year-old female and her 28 year-old brother visited the out-patient clinic because of low back pain which lasted for the past 14 and 9 years, respectively. HLA examination revealed positive B27 antigen, X-ray and CT examination clarified sacroiliitis (grade III) in both patients. The diagnosis of AS was made and drug therapy with several non-steroidal anti-inflammatory drugs was started, but had little effects in both patients. After combination therapy with 2 g/day of SASP and 20 mg/day of tenoxicam, both clinical and laboratory abnormalities disappeared within a month. It is well known that AS has hereditary characteristic, nevertheless there were only a couple of case reports which showed familial occurrence of AS and there was no report showing the effectiveness of SASP for the drug therapy of AS in Japan. The patients reported here were the first cases with AS occurred in sister and brother in Japan. We emphasized SASP might be a drug which is useful for the treatment of AS.
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PMID:[Successful treatment with salazosulfapyridine in cases sister and brother with ankylosing spondylitis]. 809 54

Rheumatic patients very often suffer from chronic pain and impairment and show psychological reactions as a consequence of their physical condition. These reactions may vary from psychophysiological symptoms to anger, anxiety, or depression. We developed a cognitive-behavioral treatment programme in a group setting format with components of relaxation, cognitive restructuring, and the promotion of well-being. Subjects included in the study were given diagnoses of low back pain, tension headache, rheumatoid arthritis, and ankylosing spondylitis. Treatment effects in different diagnostic groups were compared to each other, supporting the assumption that pain reduction is greatest in low back pain and least in ankylosing spondylitis. Subjects with inflammatory rheumatic diseases showed some improvement in self-reported physical complaints and in their feelings of well-being.
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PMID:Group treatment for pain and discomfort. 833 93

The Rome and New York criteria for ankylosing spondylitis (AS) have been compared in a clinical sample of patients with this disease and other joint disorders. The best individual clinical discriminator was the first Rome criterion, low back pain and stiffness lasting for three months and, in contrast, the New York criterion of dorsolumbar pain performed poorly. On the other hand, the more stringent New York formulation of lumbar spine limitation in all three planes came out as a better discriminator than its Rome counterpart. Both sets of radiographic criteria performed well. Ethical problems remain, which suggests that new criteria need to be developed for use in population surveys. Peripheral joint involvement was also assessed, but there did not appear to be any merit in taking this into account in any subsequent revision of diagnostic criteria for AS.
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PMID:Observations on diagnostic criteria for ankylosing spondylitis. 845 98

Six cases of ankylosing spondylitis (AS) complicated with acute anterior uveitis (AAU) were reviewed. Clinical and radiologic findings of these cases were correlated with HLA-B27. All the patients were men; four of them were HLA-B27 positive, and two were B27 negative. The average age of onset was younger in B27+ patients than in B27- patients. Ophthalmologic study showed no definite difference in inflammatory change of AAU between B27+ patients and B27- patients. AAU in B27+ patients was completely cured in three months. A history of low back pain was more apparent in B27+ than in B27- patients. Three out of four B27+ patients showed complete bony ankylosis in sacroiliac joints, whereas no ankylosis was seen in B27- patients. CT scan was useful to demonstrate sacroilitis in cases with equivocal radiologic findings. Spondylitic changes were more extensive in B27+ than in B27- patients. The results support the concept that HLA-B27+ AS and B27- AS are different entities with similar phenotypic expression, and HLA-B27 is an arthritogenic gene in the Japanese population as well.
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PMID:[Ankylosing spondylitis with acute anterior uveitis--correlation between HLA-B27 and clinical and radiologic findings]. 849 71

A 37-year-old man with ankylosing spondylitis (AS) and psoriasis who was successfully treated with methotrexate (MTX) is reported. In 1980, he had low back pain, limited motion in the lumbar spine, radiological findings of bilateral sacroiliitis, and HLA-B27 positivity. In January 1991, he developed psoriasis and he had difficulty in performing desk work in spite of treatment with antirheumatic drugs. In May 1991, MTX 7.5 mg/week per os was started. Joint symptoms, psoriasis, and acute phase reactants improved within 1 month after the treatment and this improvement continued for more than 6 months after the treatment. After discharge he was able to return to his job.
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PMID:Ankylosing spondylitis successfully treated with methotrexate. 849 46

Lornoxicam (chlortenoxicam), a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties, is available in oral and parenteral formulations. It is distinguished from established oxicams by a relatively short elimination half-life (3 to 5 hours), which may be advantageous from a tolerability standpoint. Data from preliminary clinical trials suggest that lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam was also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. Lornoxicam has a tolerability profile characteristic of an NSAID, with gastrointestinal disturbances being the most common adverse events. Limited clinical experience to date suggests that, as with a number of other NSAIDs, lornoxicam may provide a better-tolerated alternative or adjuvant to opioid analgesics for the management of moderate to severe pain. It has also demonstrated potential as an alternative to other NSAIDs for the management of arthritis and other painful and inflammatory conditions. These preliminary findings require confirmation in further comparative and long term studies.
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PMID:Lornoxicam. A review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions. 870 98

Eighteen bone scintisans performed in 14 patients with ankylosing spondylitis were reviewed. In young patients with low back pain, positive serology, and indeterminate radiographs, quantitative sacroiliac joint assessment and the presence of typical uptake patterns, particularly costovertebral, were useful in suggesting the diagnosis. Scintigraphy was helpful in the early detection of pseudoarthrosis complicating long-standing disease, especially in patients presenting with recurrent back pain. Selective application of bone scintigraphy aids the diagnosis of ankylosing spondylitis and its potential complications.
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PMID:Applications of bone scintigraphy in ankylosing spondylitis. 911 33


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