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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An extreme unilateral muscular atrophy of the shoulder and upper arm region was a symptom of juvenile ankylosing spondylitis in a 20-year-old female patient. No pathological patterns were found in electromyographic, bioptic, and tomographic (CT, NMR) investigations. The muscular atrophy was caused by a shoulder arthritis with severe erosive damage. The false assumption of a neurological disorder and the disregard of anamnesis and low back pain delayed for several years an accurate diagnosis. After the onset of an arthritis of hip joints a collagen disease with myositis was supposed falsely in spite of normal electromyographic results. The unusual muscular atrophy around the shoulder joint probably must be interpreted as a consequence of reflex inhibition and partly due to inactivity. A real myositis seems to not be probable, because newer investigations in contrast to earlier findings show no evidence for inflammatory muscle disease in ankylosing spondylitis.
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PMID:[Extreme atrophy of the shoulder muscles in juvenile ankylosing spondylitis as a (misleading) main symptom]. 260 97

Although a rare disorder, ankylosing spondylitis is often considered in the differential diagnosis of low back pain. The disease primarily affects young white men and is characterized by early morning stiffness in the lower back that typically improves with activity. Patients often have tenderness over one or both sacroiliac joints and limited spinal mobility. With large doses of nonsteroidal antiinflammatory drugs and prompt physical therapy, disability may be kept to a minimum and survival is near normal.
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PMID:Ankylosing spondylitis. An optimistic outlook. 266 53

Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male:Female = 11.2:1), and in over three-fourths the age of onset was between 10 and 39. Low back pain and peripheral arthritis as the initial manifestations were observed in 78.68 and 55.73% of patients respectively. Peripheral arthritis was evident during the course of illness in 72.13% of cases, oligoarticular arthritis being predominant (68.97%). Heel pain, tendonitis and plantar pain were noted in 19.67, 4.92 and 3.28% respectively. Most patients had lumbosacral and thoracic spine involvements, and only 49.18% showed involvement of the cervical spine. Bilateral sacroiliitis was noted in 98.36%. Uveitis was evident in 11.47% while evidence of aortic insufficiency was noted in 3.28%. An association with HLA-B27 was encountered in 91.07% of all cases. In general, the clinical features of AS in Thai patients are similar to those reported elsewhere, but an association with inflammatory bowel disease and Behcet's disease are notably absent.
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PMID:Clinical study of Thai patients with ankylosing spondylitis. 315 30

The modified New York criteria for the diagnosis of ankylosing spondylitis were evaluated and compared to the older criteria in 151 patients, referred to hospital because of low back pain and who had a positive clinical history screening test for ankylosing spondylitis and in 31 controls with non-inflammatory back pain. Radiological examination of the sacro-iliac joints showed sacro-iliitis in 124 (82%) from the 151 with inflammatory back pain. In 110 (72%) of those patients a diagnosis of definite ankylosing spondylitis according to the classical New York criteria could be made and they had a prevalence of HLA-B27 of 84%. Application of the modified New York scheme increased the number of patients meeting the criteria for definite ankylosing spondylitis to all 124 patients with sacro-iliitis, and 82% of this group carried HLA-B27. The classical New York criteria of 'limitation of the lumbar spine in three directions' and of 'limitation of chest expansion' appeared to reflect disease duration rather than help in the initial diagnosis.
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PMID:Evaluation of diagnostic criteria for ankylosing spondylitis: a comparison of the Rome, New York and modified New York criteria in patients with a positive clinical history screening test for ankylosing spondylitis. 316 Apr 23

Genetic factors other than HLA-B27 may play a role in the pathogenesis of ankylosing spondylitis (AS), acute anterior uveitis (AAU) and Reiter's syndrome (RS). Studies by Brewerton et al. and Kijlstra et al. showed associations between the MZ phenotype of alpha 1-antitrypsin and the Gm phenotype zafngb of IgG in patients with AAU, who developed AS. The loci for alpha 1-antitrypsin (PI) and Gm allotypes (IGH) are situated on the tip of the long arm of chromosome 14. In the present study we tried to clarify and extend the above studies. In 41 B27+ AAU patients with AS the alpha 1-antitrypsin and Gm phenotype and allotype frequencies were not statistically different from those in B27+ AS patients developing AAU and in B27+ AAU patients without AS, in B27+ AS patients without AAU, B27+ patients with Reiter's syndrome, B27+ patients with low back pain, B27- AAU patients and normal controls. It is therefore unlikely that genes on the tip of chromosome 14 play a role in the pathogenesis of B27 associated diseases. A hypothesis was formed suggesting that a bacterial-derived modifying factor may replace the position of beta 2 microglobulin in the HLA-B27 molecule resulting in an impaired cytotoxic T cell reactivity.
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PMID:Genes on chromosome 14q and their role in the pathogenesis of HLA-B27 associated diseases. 349 3

A middle-aged man presented with a 10-year history of intermittent low back pain. Radiological examination of the spine disclosed findings of both ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (DISH). Radiography of the hands showed the typical enthesopathy of DISH. To our knowledge this is the 2nd published case on the coexistence of the two diseases.
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PMID:Coexistence of ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis: another report. 350 68

We surveyed general and family practitioners to evaluate their patterns of referring musculoskeletal disease patients to rheumatologists and orthopedists. Patients who had rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis were most often referred to rheumatologists, whereas patients with osteoarthritis, persistent low back pain, and post-traumatic knee pain were most often referred to orthopedists. As conditions worsened in severity, referrals were more frequent. Patients with conditions that were difficult to diagnose, such as possible shoulder tendinitis that was unresponsive to initial nonsteroidal therapy, undiagnosed polyarthritis, and intermittent knee swelling with pain, were most often treated without referral and, when referred, were most often sent to orthopedists. Belief in the effectiveness of rheumatologists or orthopedists correlated strongly with reported referral behavior, yet most respondents considered themselves capable of managing the majority of patients with musculoskeletal diseases. Neither practice arrangement, board certification, nor educational background affected referral behavior. However, younger physicians were more likely (P = 0.002) to refer patients to rheumatologists. Multivariate analysis showed that the significant predictors of global referral behavior were belief in the effectiveness of subspecialists and a small number of musculoskeletal problems seen by the generalist. The predictors of referral to rheumatologists were belief in rheumatologist efficacy and young physician age.
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PMID:Referral of musculoskeletal disease patients by family and general practitioners. 405 27

In a cross-sectional study designed to investigate the sensitivity of infra-red thermography in the detection of sacro-iliac regions were examined by thermography in a group of patients with ankylosing spondylitis and compared with normal volunteers and patients with other causes of low back pain. Thermograms were recorded both quantitatively via profile measurements across the sacro-iliac regions and sacrum and qualitatively via the pattern recorded by photography. Sacro-iliac disease activity was recorded clinically on the same day and was low overall in the patients examined. Thirteen of the 30 ankylosing spondylitis patients were abnormal thermographically either by profile or pattern measurements. None of the 13 patients with other causes of low back pain had increased sacro-iliac activity on thermography. None of four patients without X-ray evidence of sacro-iliitis was abnormal thermographically but there was a trend for increasing thermographic activity to be associated with increasing clinical activity. It was concluded that the thermographic technique examined was of little help in the diagnosis of early sacro-iliitis but might be more helpful in the objective serial assessment of sacro-iliitis in individual patients with active disease.
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PMID:Infra-red thermography in the assessment of sacro-iliac inflammation. 621 Sep 49

Detailed medical histories were obtained from 122 consecutive patients with Bechterew's syndrome (ankylosing spondylitis) who had been hospitalized at Oslo Sanitetsforening Rheumatism Hospital. Frequencies of symptoms, age at onset of symptoms and their interrelationships are presented. Low back pain affected more patients than any other symptom and, generally speaking, it started earlier than any other individual symptom. However, any symptom could antedate low back pain. Symptoms preceding low back pain were most frequently reported at a young age, and most often affected the extremities. The presence of psoriasis was associated with an increased frequency of symptoms in the peripheral joints. Acute anterior uveitis and chest stiffness were more common in males than in females. The influence of the selection of patients on the results is discussed.
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PMID:How does Bechterew's syndrome (ankylosing spondylitis) start? Interrelations between onset of symptoms. 622 92

Forty-five of 52 consecutive patients with chronic low back pain were screened for presence of HLA-B27 antigen one year after they were included in a rehabilitative program. Six (13.3%) were positive and, when re-examined radiographically, 2 had signs of ankylosing spondylitis. The proportion of antigen-positive individuals is similar to that found in a population study of healthy Swedish blood donors, and within the range of other populations of healthy controls. It is concluded that HLA-B27 is of limited diagnostic value as a screening test for ankylosing spondylitis in a patient group with chronic low back pain.
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PMID:HLA-B27 as a diagnostic screening tool in chronic low back pain. 623 21


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