Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Basing on roentgenological observation of the course of the disease, and on postmortem examination, of a patient with polysegmental Andersson lesions (known as spondylodiscitis) in ankylosing spondylitis, the article reports on the histological and often also clinico-roentgenological possibility of differentiating between an inflammatory and non-inflammatory type of this destructive lesion. The non-inflammatory type of Andersson lesion reflects a fracture due to fatigue, or its sequel, eg pseudarthrosis, in the stiffened axial skeleton. In this particular patient, renal osteopathy had favoured the genesis of the disease.
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PMID:[Polysegmental andersson lesion in ankylosing spondylitis (roentgenological-histological synopsis) (author's transl)]. 15 1

Echocardiographic evidence has suggested abnormalities of the myocardial function in patients with ankylosing spondylitis. In this work the cardiac function in patients with ankylosing spondylitis and in normal volunteers was evaluated. Twenty four normal volunteers and 21 patients with ankylosing spondylitis aged 18-45 were studied. None had overt cardiac disease. Cardiac function was assessed at rest with echocardiography, at rest and during supine bicycle exercise using radionuclide angiography in the left anterior oblique position following equilibration with 740 MBq of technetium-99. The subjects undertook supine bicycle exercise with 30 W increments every three minutes to the point of fatigue. Comparison of data from normal volunteers and patients with ankylosing spondylitis were made using Student's t test for independent samples or the Mann-Whitney non-parametric technique, as appropriate. Subjects were matched for age, sex, height, and weight. There were no echocardiographic differences; however, global nuclide left ventricular function showed several differences between normal volunteers and patients with ankylosing spondylitis. The peak filling rate during exercise was significantly lower in patients with ankylosing spondylitis: normal volunteers 6.5 (SD 1.2); patients with ankylosing spondylitis 5.7 (1.2). The time to reach peak filling during exercise was significantly lower in patients with ankylosing spondylitis: normal volunteers 102 (22); patients with ankylosing spondylitis 120 (23). Regional analysis also showed differences between patients with ankylosing spondylitis and normal volunteers both at rest and during exercise. In the anteroseptal region the filling fraction and peak filling rate were significantly lower in patients with ankylosing spondylitis. Most of the differences (although not all) were in the variables of diastolic function. This study shows that there are subtle abnormalities in cardiac function in patients with ankylosing spondylitis. The major abnormalities are in the diastolic function, suggesting a decrease in left ventricular compliance.
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PMID:Myocardial dysfunction in ankylosing spondylitis. 155 Apr 8

Shoulder muscle performance was tested in 8 working ankylosing spondylitis (AS) patients and compared with 10 healthy male referents. The AS patients were all in a non-active state and had no shoulder symptoms. Electromyographic fatigue development in the descending part of the trapezius muscle was significantly faster in the AS group during an endurance time test than in the referents. This indicates a change in muscle function consistent with previous reports of myopathy in AS patients. There were no significant differences in shoulder forward flexion strength, endurance time or recovery of endurance time between the AS patients and the referents.
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PMID:Shoulder muscle strength, endurance and electromyographic fatigue in ankylosing spondylitis. 360 50

25 men and 25 women with ankylosing spondylitis were interviewed, using a structural questionnaire, covering a profile of the disease and of socioeconomic areas. Particular attention was paid to sexual activity, pregnancy and child-rearing. Significant problems in most areas asked about were found, although childbearing was not curtailed. Tiredness was responsible for a lot of disability but the women managed housework reasonably well and also had a fairly good employment record.
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PMID:Socioeconomic effects of ankylosing spondylitis in females: a comparison of 25 female with 25 male subjects. 665 22

One hundred individuals with ankylosing spondylitis (AS) and 57 individuals a comparison group responded to a questionnaire concerning subjective symptoms from the stomatognathic system and general joint symptoms. It was concluded that the individuals with AS have more subjective symptoms from the stomatognathic system, especially difficulties in wide mouth opening, than the comparison group. Specific temporomandibular joint (TMJ) involvement in AS was difficult to determine but pain in the TMJ region, stiffness/tiredness in the jaws and with AS. TMJ involvement was also correlated to the severity and extension of the AS. In the comparison group awareness of parafunctions such as tooth-clenching and tooth-grinding were important subjective factors correlated to their symptoms from the stomatognathic system.
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PMID:Subjective symptoms from the stomatognathic system in ankylosing spondylitis. 695 67

The efficacy and agreeability of a supportive drug therapy at doses of 300 mg of proquazone (Biarison) administered thrice daily was tested in an open study of 4 weeks' duration in 10 male patients suffering of clinically verified ankylosing spondylitis. The minimum duration of suffering was 15 years, the maximum 50 years. The major goal of therapy during clinical treatment was individually oriented physical therapy suited to the enhancement of residual mobility, removal of postural abnormalities and abnormalities of weight-loading as well as the maintenance of functionality for afflicted skeletal regions. In the course of this additional therapy with proquazone the functional index and activity index both displayed significant improvement (2 p less than 0.01), as compared with the control subjects. Improvement was attained as soon as 2 weeks following begin of therapy. In the course of treatment the following parameters also displayed significant improvement (2 p less than 0.05): morning stiffness, fatigue, patient's self-evaluation, Westergren one-hour-value, physician's over-all assessment, night pain, articular pain, thoracic and lumbar pain. There were only insignificant changes in other, regularly tested laboratory values during this drug therapy. No side effects or disagreeability signs of proquazone were noted. Proquazone can be recommended for the symptomatic additional treatment of patients suffering from ankylosing spondylitis.
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PMID:[Ankylosing spondylitis. Pathogenesis and therapy]. 722 33

Reactive arthritis following infection with enteropathogenic bacteria is usually a self-limiting disease that disappears after a few months without sequela. We describe two girls who developed carditis shortly after the onset of reactive arthritis due to infection with Salmonella enteritidis. The carditis presented with fatigue and arrhythmia and involved the aortic valve in both patients leading to definite aortic regurgitation in one. A similar pattern of cardiac involvement is found in other spondyloarthropathies, including Reiter's syndrome and ankylosing spondylitis. We conclude that Salmonella reactive arthritis may be complicated by carditis.
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PMID:Reactive arthritis due to Salmonella enteritidis complicated by carditis. 784 47

The purpose of the study was to investigate whether fibromyalgia patients (n = 50) differed from patients with rheumatoid arthritis (n = 22) and ankylosing sponylitis (n = 31) with respect to pain experience, pain coping and fatigue. A high general pain intensity level was recorded by the McGill Pain Questionnaire (p < 0.01) and the visual analogue scale (p < 0.01) in the fibromyalgia group compared to the other groups. The pain was of continuous duration in the fibromyalgia patients while the rheumatoid arthritis and ankylosing spondylitis patients experienced intermittent pain. A high correlation between sensory and affective pain rating indexes was determined in all patient groups (p < 0.01). No statistically significant difference between the groups in pain coping was recorded. A high frequency of reported gastrointestinal problems (p < 0.01) and high intensity of fatigue (p < 0.01) were seen in the fibromyalgia group compared to the other groups. In the fibromyalgia group there was no correlation between the sleep problems and fatigue intensity. Thus, the fibromyalgia patients differed from the other groups in reporting frequently shoulder and upper arm pain, continuous pain, higher levels of fatigue and pain intensities as well as high frequency of gastrointestinal problems.
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PMID:Pain and fatigue in patients with rheumatic disorders. 812 15

A multiplanar approach and a good tissue differentiation characterize magnetic resonance imaging which have a great role in exploring numerous musculo-skeletal lesions; review of main indications and limits. MRI is useful in diagnosing certain undisplaced fractures, fatigue and insufficiency fractures, and consequences. Fibrous cartilage and hyalin cartilage lesions, tears of tendons, ligaments and muscles are well appreciated. MRI is also very good for an early and correct diagnosis of avascular necrosis, spinal degenerative lesions, spinal consequences of rheumatoid arthritis and ankylosing spondylitis, and bone metastases. It is the technique of choice for local staging of bone and soft tissue sarcomas.
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PMID:[Magnetic resonance imaging of the locomotor apparatus]. 876 42

Although a number of reports have now described an association between polymorphism of the LMP2 gene and disease phenotype in HLA-B27 positive individuals with ankylosing spondylitis (AS), some describe associations with acute anterior uveitis, others with juvenile onset disease, and one report provides no association. A recent study describes yet a further association with disease severity in patients with juvenile rheumatoid arthritis. We therefore hypothesized that the discrepant findings in adult disease may be a reflection of an underlying association with disease severity. Our study population consisted of 100 HLA-B27 positive Caucasians with AS of ten or more years duration. Clinical assessment of disease severity was based on a metrology index scoring five measurements, the modified health assessment questionnaire for the spondyloarthropathies, and a disease activity index consisting of a visual analog scale to score the amount of pain, stiffness and fatigue. LMP2 genotypes were assigned following polymerase chain reaction amplification from genomic DNA and restriction enzyme digestion with CfoI. Despite confirmation of a significantly higher prevalence of the LMP2 BB genotype in AAU positive (66.0%) versus AAU negative (45.2%) patients (P < 0.05), we observed no association between LMP2 genotypes and any of the indices of disease severity. Furthermore, although a significant association was noted between the presence of peripheral synovitis and the functional index score (P < 0.05), a history of AAU was not associated with more severe disease. Our data is thus internally consistent in demonstrating no association between LMP2 genotypes and either disease severity or peripheral arthritis, and supports the notion that polymorphism of LMP2 primarily influences the development of AAU and not some other phenotype of AS.
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PMID:Polymorphism of the LMP2 gene and disease phenotype in ankylosing spondylitis: no association with disease severity. 934 40


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