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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the study was to compare the spondyloarthropathy of ankylosing spondylitis (AS) to that of psoriatic arthritis (PsA). Forty patients with AS and 66 patients with PsA underwent a complete assessment according to a standard protocol, including radiographic evaluation and HLA typing. A logistic regression analysis was performed controlling for age, arthritis duration, and sex. A higher frequency of inflammatory neck and back pain and stiffness (p < 0.0002), limitation of back movements (p < 0.0006), grade 4 sacroiliitis (p = 0.007), and syndesmophytes (p = 0.005) was noted in AS, while peripheral arthritis was more common and more severe in patients with PsA (p = 0.002). A lower frequency of HLA B17 (p = 0.02), and a higher frequency of HLA B27 (p = 0.0001), and Cw2 (p < 0.01) was found in AS compared to PsA. Thus, there are clinical, radiologic, and genetic differences in disease expression of the SA of AS and PsA, supporting their classification as distinct entities.
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PMID:Differences in the expression of spondyloarthropathy: a comparison between ankylosing spondylitis and psoriatic arthritis. 846 76

Three-hundred-and-thirteen back pain sufferers completed a screening questionnaire for inflammatory back pain. This was positive in 46 (15%), who were invited for a further examination. Only two of these patients had definite ankylosing spondylitis. Eighteen of them (39%) had other features associated with spondyloarthropathy. It is suggested that up to 5% of back pain sufferers may have a mild form of ankylosing spondylitis that may never progress to definite ankylosis, but for whom treatment as if they had ankylosing spondylitis may be of benefit.
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PMID:Inflammatory back pain in primary care. 854 11

Vertebral osteoporosis is a well-recognized feature of ankylosing spondylitis (AS) and also the vertebral compression fractures due to osteoporosis are a common but frequently unrecognized complication of AS. Both may contribute to the pathogenesis of spinal deformity and back pain. The aim of this study was to measure vertebral and femoral neck bone mass in patients with AS by dual photon absorptiometry, to determine the prevalence of compression fractures and to examine the relationship between bone density and disease severity. We found that the bone mass was diminished in the lumbar spine in moderate AS versus mild forms but the patients with advanced disease had the highest BMD values. Examination of spinal radiographs revealed compression and biconcave fractures in 9 (40.9%) cases. Neither the duration of the disease and the degree of sacroiliitis, nor the disease activity assessed by laboratory and clinical parameters was found to significantly affect the results.
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PMID:Bone mineral density in ankylosing spondylitis. 892 76

A 41-year old caucasian male presented with limited range of motion of the entire spine and myogenous intermittent claudication. He was referred with the diagnosis "ankylosing spondylitis". The clinical picture mimicked ankylosing spondylitis, but there were no corresponding radiological abnormalities despite a 13-year history of his disease. Laboratory values showed markedly elevated levels of muscle enzymes. The diagnosis of rigid spine syndrome, a subtype of muscular dystrophy, was made from the clinical picture a normal EMG and degenerative changes on a biopsy from the muscle trapezius. We would like to draw attention to this rare cause of back pain.
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PMID:[Possible diagnostic error of "Bechterew disease"]. 904 30

Seronegative and HLA B27-associated spondyloarthropathy (SpA) is a heterogeneous disease, so far without a clear origin. The term comprises five clinically defined subcategories: ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), inflammatory bowel disease-associated arthritis and undifferentiated spondyloarthropathy (uSpA). Sacroiliitis, an inflammatory involvement of one or both sacroiliac joints, is the key symptom of all spondyloarthropathies. Sacroiliitis is often associated with inflammatory back pain, manifest as deep nocturnal back pain that is improved by exercise. The pathogenesis of SpA and the reason for the tropism for the sacroiliac joints is still obscure. A genetic background of an initially bacterial triggered infection seems to be most likely.
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PMID:[Sacroiliitis: the key symptom of spondylathropathies. 1. The clinical aspects]. 911 65

Eighteen bone scintisans performed in 14 patients with ankylosing spondylitis were reviewed. In young patients with low back pain, positive serology, and indeterminate radiographs, quantitative sacroiliac joint assessment and the presence of typical uptake patterns, particularly costovertebral, were useful in suggesting the diagnosis. Scintigraphy was helpful in the early detection of pseudoarthrosis complicating long-standing disease, especially in patients presenting with recurrent back pain. Selective application of bone scintigraphy aids the diagnosis of ankylosing spondylitis and its potential complications.
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PMID:Applications of bone scintigraphy in ankylosing spondylitis. 911 33

Ankylosing spondylitis is a systemic disease typically manifested by persistent back pain or stiffness unrelieved by rest. Although not often recognized, ankylosing spondylitis can also cause peripheral joint pain, particularly in the hips, knees, ankles, and shoulders. In the pediatric form of the disease, juvenile ankylosing spondylitis, peripheral joint involvement is more frequent and can precede, by many years, the onset of back symptomatology. The following case is an example of a teenager who presented to physical therapy with a variety of common peripheral joint complaints over a 3-year period. Eventually, he was diagnosed with juvenile ankylosing spondylitis. Lack of awareness of the manifestations of ankylosing spondylitis and juvenile ankylosing spondylitis may lead to significant delay in diagnosis and initiation of appropriate therapy. A physical therapist may be the first health professional to assess a patient's lack of response to treatment for a seemingly typical diagnosis and should be aware of potential alternate diagnoses.
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PMID:Shoulder, knee, and hip pain as initial symptoms of juvenile ankylosing spondylitis: a case report. 947 41

Therapeutic trials in rheumatoid arthritis (RA), osteoarthritis, seronegative spondyloarthopathies, back pain, systemic lupus erythematosus, and systemic sclerosis are reviewed. For RA, minocycline has been proven effective in some subsets of RA, whereas tumor necrosis factor receptor IgG fusion protein appears quite effective for treating the symptoms of RA in a more resistant group. The latter trial illustrates the importance of tumor necrosis factor in RA. Also, the triple combination of hydroxychloroquine, sulfasalazine, and methotrexate is very effective even in resistant RA. In osteoarthritis, the effects of nonsteroidal anti-inflammatory drugs, intra-articular steroids, and biologics are reviewed, with generally nondifferentiable nonsteroidal anti-inflammatory drug effects and some short-term intra-articular effects of new biologics. Sulfasalazine is moderately effective for ankylosing spondylitis and psoriatic arthritis, although the large placebo response in the latter makes it more difficult to show responses. Trials in the treatment of back pain are beginning to be published, with a large cohort study over 1 year favoring surgery for early relief of pain in both sciatica and lumbar stenosis, but not showing a clear advantage in functional outcome at 1 year. Finally, early reports show the ability of dihydroepiandrosterone to decrease steroid use in systemic lupus erythematosus, whereas Relaxin appears to be effective in decreasing skin involvement in systemic sclerosis. These trials demonstrate in numerous ways the need to consider the elements of good trial design when testing therapeutic modalities in the rheumatic diseases. These key elements include 1) careful patient definition and selection; 2) removal of bias (requiring blinding, randomization, prospective studies, and often, placebo); 3) use of well-defined outcomes; and 4) careful analytic techniques.
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PMID:Update on clinical trials in the rheumatic diseases. 956 7

Eighty-eight Thai patients (61 males and 27 females) with spondyloarthropathy (SpA) were studied. Their mean age and mean duration of the disease were 25.97 and 3.34 years respectively. In 16 cases the disease first appeared before the age of 16 or had juvenile onset. Eleven cases were ankylosing spondylitis (AS), 9 were juvenile AS (JAS), 20 were Reiter's syndrome (RS), 4 were juvenile RS, 14 were psoriatic arthritis (PsA), 27 were undifferentiated SpA (uSpA), and 3 were juvenile uSpA. Peripheral arthritis, especially oligoarthritis of the lower extremity joints, was the most common form of arthritis in all groups, except for PsA, where polyarthritis was common. Back pain and bilateral sacroiliitis were commonly seen in JAS and AS. Enthesopathy was not uncommon. Extra-articular manifestations were more common in RS patients. Acute inflammatory eye diseases were seen in 45 per cent of AS and 66 per cent of RS cases. In general, the clinical features of Thai patients with SpA were similar to those reported in other countries in Asia and the west.
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PMID:A clinical study of Thai patients with spondyloarthropathy. 991 88

The education of rheumatic patients in Croatia has begun in 1975 by introducing the school of back pain. Soon after that has begun the education of children with scoliosis. The education of patients with rheumatoid arthritis and ankylosing spondylitis was establish in 1985. Along with the courses of patient's education, there were printed a publications dedicated to the same problem. At the beginning there was printed a textbook Rheumatic diseases with training for rheumatic patients (1978.) and then textbook Jogging (1982.) and Reta (1984.). During 1994, there were graduated a publications dedicated to the disease having the same name: Rheumatoid arthritis, Ankylosing spondylitis, Uric arthritis and Psoriatic arthritis, which were reprinted in enlarged form (1997). Protection of the joints in rheumatic disease (1998.) is a new textbook for patients about correctly usage of the joints. Textbook Prevention of back pain and neck pain (1998.) is dedicated to healthy people for the prevention of pain syndromes of vertebra. Thus, the education was introduced in almost all parts of rheumatology and in whole Republic of Croatia.
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PMID:[History of patient education in rheumatic diseases in Croatia]. 992 Oct 7


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