Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The usefulness of amyloid-related serum protein (SAA) as an indicator of disease activity has been evaluated in 11 patients with rheumatoid arthritis (RA), 2 patients with psoriatic arthritis (PA) and 13 patients with ankylosing spondylitis (AS) prospectively studied during and after pregnancy. For comparison, SAA levels were recorded serially during and after pregnancy in 28 healthy pregnant women. SAA levels were unaltered by gestation and thus within the normal range during normal pregnancy, but were raised in healthy pregnant women with episodes of intercurrent infections. In RA and AS patients, SAA concentrations correlated to disease activity during and after pregnancy. Serial levels of SAA and C-reactive protein in healthy women and patients paralleled each other with the most pronounced inflammatory response displayed by SAA. We conclude that SAA is a sensitive and reliable indicator of inflammatory events both in the pregnant and non-pregnant state.
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PMID:Amyloid-related serum protein (SAA) during and after pregnancy in healthy women and women with rheumatic disease. 398 47

Serum and EDTA blood from 120 patients with ankylosing spondylitis (Bechterew's syndrome) and serum from 138 first-degree relatives of patients and from 42 adult blood donors were investigated. Increased serum concentrations of IgA and IgG and complement factors C3 and C4 were found in total groups of HLA B27-positive male or female patients compared with controls or relatives. The men had higher serum concentration of IgA and complement factors than the women, whereas IgM concentration was higher in the women. These patterns were found in controls, in relatives and in patients. Increased concentrations of IgA and of C4 were characteristic of all patients whereas IgG and IgM and C3 concentrations were likewise elevated in patients with peripheral joint arthritis/arthropathy. Increased levels of circulating immune complexes (CIC) were associated with peripheral joint arthritis and were strongly correlated with IgG or CRP concentrations in serum. Total haemolytic complement activity in serum was negatively correlated with concentrations of CIC or CRP indicating complement activation in patients with such complexes. No differences in serum concentrations of Ig or complement factor concentrations were seen between HLA B27-positive and negative relatives with normal sacro-iliac joints or between relatives and controls. Strong mutual correlations were seen among IgG, IgM, complement factors, CRP, SAA, sedimentation rate and alpha 2-macroglobulin. When the present findings were combined with our previous results it turned out that AS, and psoriasis with or without arthropathy, and acute anterior uveitis (AAU) in combination with sacro-iliitis, may be described as IgA-related conditions and that increased serum C4 was related to sacro-iliitis in all these disorders.
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PMID:Immunological variables and acute-phase reactants in patients with ankylosing spondylitis (Bechterew's syndrome) and their relatives. 633 23