Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Echocardiography has been useful in the evaluation of congestive and hypertrophic cardiomyopathies. We present echocardiographic findings in seven patients with infiltrative cardiomyopathy due to amyloid. Cardiac amyloidosis was documented at autopsy in two patients, and the diagnosis was suggested by clinical, echocardiographic, tissue, or hemodynamic findings in the other five. Hemodynamic findings in three patients mimicked constrictive pericarditis; and autopsy was performed on one of the three and showed a normal pericardium. Underlying disorders were multiple myeloma (five patients), ankylosing spondylitis (one patient), and an unknown disorder (one patient). The basic echocardiographic findings in infiltrative cardiomyopathy due to amyloid were (1) symmetrically increased left ventricular wall thickness (in the absence of hypertension or aortic valvular disease), (2) hypokinesia and decreased systolic thickening of the interventricular septum and left ventricular posterior wall, and (3) small to normal size of the left ventricular cavity. Two patients also had small pericardial effusions. Thus, in a patient with congestive heart failure, these echocardiographic findings should suggest infiltrative cardiomyopathy.
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PMID:Echocardiographic manifestations of infiltrative cardiomyopathy. A report of seven cases due to amyloid. 100 Oct 49

Aortic valve disease of autoimmune disease is complicated in pre-, peri- and post-operative care. Recommended care in aortitis, ankylosing spondylitis, systemic lupus erythematosus and rheumatoid arthritis were described. Surgical strategy should be determined depending on basic disease, degree of inflammation and region of disease. Because of the fragile tissue of autoimmune disease patient, modified Bentall procedure is recommended to prevent a prosthetic valve dropping off for aortitis. Perioperatively, it is important to control the inflammation of basic disease, thus a steroid cover is necessary perioperatively. Some complications such as infection, out-of-control of anti-coaguration or gastro-intestinal bleeding should be avoided. Post operation, a strict follow up of prosthetic valve and aorta around suture line and control of autoimmune disease should be achieved.
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PMID:[Aortic valve surgery for autoimmune disease]. 2286 21