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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A typical case of ankylosing spondylitis (AS) in a 53-year-old man illustrates the high risk of spinal injury. When compared to the healthy subjects, patients with ankylosing spondylitis are at risk even after trivial injury. Spinal epidural hematoma is rare and generally associated with significant osseous spinal column involvement. Although rare, hematoma should be considered in ankylosing spondylitis patients, when a patient develops progressive neurologic symptoms and signs. An aggressive approach, including early decompression, affords the best chance for recovery.
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PMID:Spinal epidural hematoma and ankylosing spondylitis. 372 Jan 27

Spinal epidural hematoma is an unusual condition requiring urgent neurosurgical intervention. Imaging plays an important role in the preoperative work-up. Although MR imaging is the examination of choice, a myelogram and CT myelogram are often performed in an emergency situation. The association with ankylosing spondylitis has been described and is considered a risk factor for developing a hematoma.
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PMID:Spinal epidural hematoma and ankylosing spondylitis. 926 Mar 89

We report the case of a patient suffering from spinal epidural haematoma and thoracic spinal fracture, and from ankylosing spondylitis. Fourteen cases of spinal epidural haematoma in association with ankylosing spondylitis have been reported in the literature, 12 of them at a cervical level. Spinal epidural haematoma found in patients suffering from ankylosing spondylitis share the same clinical picture as other haematomas, the notion of time being the main feature. Serious neurological complications caused the death of five patients. The case we report is singular for its thoracic localization and two attacks of total paralysis both followed by spontaneous and complete recovery. Today, MRI is the best method to reach a clear and reliable diagnosis. Widespread use of MRI will certainly increase the number of diagnoses made. Our patient underwent operation including osteosynthesis using Cotrel-Dubousset instrumentation. This enabled him to resume his professional activities only 30 days after his accident.
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PMID:Fracture of the spine, spinal epidural haematoma and spondylitis. Report of one case and review of the literature. 2005 26

Spinal epidural hematoma (SEH) is a rare cause of nerve root or cord compression; its pathogenesis is not always clearly recognizable. The aim of this paper was to investigate possible etiopathological factors in a consecutive series of patients affected by traumatic SEH treated at our institution. Seven patients with neurologic impairment due to traumatic SEH were retrospectively analyzed after diagnosis and surgical treatment. Thoracic localization was found in 5 cases, and lumbar and cervical localization were found in 1 patient each. One patient was affected by ankylosing spondylitis and one by diffuse idiopathic skeletal hyperostosis. SEH was associated with spine fractures in 6 cases. Only 2 cases of traumatic SEH resulted from high-energy trauma. All patients underwent surgical decompression within 24 hours after admittance to the hospital. Three patients recovered completely, 3 remained paraplegic, and 1 remained monoplegic. Several concomitant conditions are suggested to be predisposing factors for the development of SEH, although its inherent mechanism is still unknown. Two patients in the present series were affected by rheumatologic disorders, confirming the elevated incidence of hematomas in such patients compared to the normal population. Three very unusual cases of SEH occurred in senile patients affected by osteoporotic fractures. Early diagnosis and urgent decompression of the hematoma remain mandatory.
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PMID:Etiopathogenesis of Traumatic Spinal Epidural Hematoma. 2965 30