Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This review concentrates on certain areas of current interest in the major rheumatic diseases. In rheumatoid arthritis, there is some epidemiologic evidence that the disease is diminishing in incidence and severity. The possible protective effect on rheumatoid arthritis of the oral contraceptive pill has also attracted attention. There is some evidence that it may act by modifying the disease process. Parity may also be a protective factor in rheumatoid arthritis. Recent twin studies have suggested that the monozygotic concordance rate may be lower than previously believed, suggesting that genetic factors may only account for 20% of the disease. In osteoarthritis, new clinical criteria for the hand, knee, and hip have appeared that require further testing. The finding of a specific mutation of one amino acid of a procollagen II gene in family members with premature osteoarthritis has aroused considerable interest. There has been recent debate on the risk of developing ankylosing spondylitis in the population with HLA B27, although most believe this to be less than 7%. Scleroderma is a rare disease that may be increasing in incidence. One study has suggested the clustering of cases around airports. In the majority of countries, osteoporotic fractures appear to have increased at all ages over the last 30 years, although methods of screening using questionnaires or single bone density measurements are unlikely to be useful as widespread public health measures. The question of estrogen use is increasingly being dominated by the large cardiovascular benefit.
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PMID:The epidemiology of rheumatic diseases. 206 6

Ossification of the ligamentum longitudinale posterius is a rare disease found in particular in Japan and southeastern Asia. In the literature it is described as the so-called Japanese disease or OPLL syndrome. The disease takes a slow, frequently asymptomatic, course but may cause severe stenosis of the spinal canal with neurological disorders, OPLL occurs frequently concurrently with ankylosing spondylitis, hypertrophic spondylosis, diffuse idiopathic hyperostosis of the skeleton. Own observation: a 68-year-old man with a long history of cervicalgia, subsequently paraesthesias of the upper extremities, without a spastic atactic symptomatology of the lower extremities. An X-ray extremities, of the skeleton was made, tomograms and CT of the cervical spine. In the Cl-6 area major ossifications of the posterior longitudinal ligament were found which caused stenosis of the spinal canal of an extent of up to two thirds.
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PMID:[Ossification of the posterior longitudinal ligament in the cervical spine]. 212 18

We reported a case of ankylosing spondylitis which successfully underwent aortic valve replacement for combined aortic and mitral regurgitation. A 42-year-old man was admitted with symptoms of shortness of breath and anginal pain. He was previously diagnosed ankylosing spondylitis by an orthopedician A grade III/VI to and fro murmur was audible at the left sternal border. Retrograde aortography revealed severe aortic regurgitation and mild mitral regurgitation. Cardiac catheterization showed moderately pulmonary hypertension and high pulmonary artery wedge pressure. He underwent aortic valve replacement with SJM prosthetic valve. His postoperative course was uneventful. In Japan, ankylosing spondylitis is rare disease, and cardiac lesions associated with these conditions is seldom met to us. The surgical problems and management of these lesions are discussed.
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PMID:[A case report of combined aortic and mitral regurgitation associated with ankylosing spondylitis]. 846 47

Angiotropic lymphoma is an extremely rare disease characterized by intravascular accumulation of large neoplastic lymphocytes, with the clinical manifestations of fever, skin lesions and neurologic deficits. We report a patient who developed angiotropic lymphoma after a 10-year history of ankylosing spondylitis. The clinical disease manifested as a unilateral, solitary adrenal tumor, fever and body weight loss. The fever subsided after surgical removal of the adrenal tumor. Systemic chemotherapy was administered postoperatively. The patient was leading an uneventful life 44 months after the initial diagnosis. To our knowledge, this is the first case of angiotropic lymphoma associated with ankylosing spondylitis. It is also the second reported case manifesting with a unilateral solitary adrenal tumor without systemic involvement.
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PMID:Angiotropic lymphoma manifesting as a solitary adrenal tumor in a case of ankylosing spondylitis. 1064 53

The authors report four ankylosing spondylitis cases observed within 11 years (1990-2000) of rheumatologic exercise among 10,000 patients examined in consultation and hospitalization at Brazzaville university teaching hospital. It confirms that ankylosing spondylitis is a rare disease in sub-Saharan black Africa.
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PMID:[Four first Congolese cases of pelvic ankylosing spondylitis]. 1278 88

Osteitis condensans ilii (OCI) is known as one of the sacroiliitis diseases and the symptoms or radiographic findings of OCI sometimes resembled those of ankylosing spondylitis (AS) of non-radiographic axial spondyloarthritis (nr-axSpA). Bone marrow edema (BME) around sacroiliac (SI) joints on MRI is one of the key findings in the classification criteria of axial SpA, but BME on MRI were also found in patients with OCI. The usage of SI joint MRI is increasing due to the needs of accurate or early diagnosis of axial SpA in accordance with development of new biological treatments. Here was the case of a 38-year-old female patient with ulcerative colitis (UC) complicated with OCI, which was a mimic of AS or nr-axSpA. She had a persistent low back pain with BME around SI joints on MRI. She could meet the ASAS criteria of axial SpA and might be diagnosed with inflammatory bowel disease (IBD) related axial SpA. OCI is not a rare disease as a differential diagnosis for axial SpA especially in young women. We report this case with literature review of OCI and would like the clinicians to be aware of the disease when diagnosing AS or nr-axSpA with chronic low back pain.
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PMID:Osteitis condensans ilii in a patient with ulcerative colitis: a mimic of ankylosing spondylitis or non-radiographic axial spondyloarthritis. 3325 9