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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Various authors have advocated quantitative methods of evaluating bone scintigrams to detect sacroiliitis, while others have not found them useful. Many explanations for this disagreement have been offered, including differences in the method of case selection, ethnicity, gender, and previous drug therapy. It would appear that one of the most important impediments to consistent results is the variability of selecting sacroiliac joint and reference regions of interest (ROIs). The effect of ROI selection would seem particularly important because of the normal variability of radioactivity within the reference regions that have been used (sacrum, spine, iliac wing) and the inhomogeneity of activity in the SI joints. We have investigated the effect of ROI selection, using five different methods representative of, though not necessarily identical to, those found in the literature. Each method produced unique mean indices that were different for patients with ankylosing spondylitis (AS) and controls. The method of Ayres (19) proved superior (largest mean difference, smallest variance), but none worked well as a diagnostic tool because of substantial overlap of the distributions of indices of patient and control groups. We conclude that ROI selection is important in determining results, and quantitative scintigraphic methods in general are not effective tools for diagnosing AS. Among the possible factors limiting success, difficulty in selecting a stable reference area seems of particular importance.
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PMID:Quantitative sacroiliac scintigraphy. The effect of method of selection of region of interest. 623 2

In a retrospective analysis of 770 cases of ankylosing spondylitis or allied disorders 146 patients (19 percent) were found to have isolated sacroiliitis without involvement of the spine. The mean disease duration of isolated sacroiliitis was 11.9 years. The conclusions were based on anamnestic, clinical and radiological data. Of those patients with isolated sacroiliitis 29 percent were female, compared to 11 percent of female patients with typical spinal disease. Cases restricted to the sacroiliac joints for a longer period can be observed frequently in younger patients and may be regarded as an abortive and monosymptomatic form of ankylosing spondylitis insofar as other seronegative spondarthritides can be excluded.
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PMID:Isolated sacroiliitis as monosymptomatic form of ankylosing spondylitis--a possible cause of chronic back pain. 623 19

HL-A antigens were determined in Haida and Bella Coola native Indians, two communities known to have a high prevalence of ankylosing spondylitis. Tests were conducted on those with x-ray evidence of sacroiliitis and on a sample of the community at large. Sacroiliitis was found to prevail in approximately 10% of adult Haida males and in over 2% of Bella Coola adult males. Of 20 Haidas with sacroiliitis. 17 were HL-A 27 positive. Fifty percent of the Haida community at large were HL-A 27 positive. Three Bella Coolas known to have sacroiliitis were all HL-A 27 positive, while 25% of the community sampled at large were HL-A 27 positive. About one in five adult Haida males who were HL-A 27 positive showed evidence of sacroiliitis, a proportion close to that ascertained in Caucasian communities. It would appear, therefore that the risk of disease in HL-A 27 positive Bella Coola males is considerably lower.
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PMID:HL-A 27 and ankylosing spondylitis in B.C. Indians. 633 37

Clinical, radiological and scintigraphic studies and HLA type assessment were performed in 38 subjects, constituting all the first-degree members of three generations of the families of six patients affected with ankylosing spondylitis (AS). The families included both parents, all siblings and all children of the probands. Definite AS was found in three men and possible AS in another. In another man and in a woman, a diagnosis of asymptomatic bilateral sacroiliitis was made. These six subjects indicate a family prevalence of AS reaching 15.8%. HLA B27 was present in 20 individuals (52.6%), including those with definite and possible AS and the case with asymptomatic sacroiliitis. The woman with asymptomatic sacroiliitis lacked HLA B27 antigen. Our study confirms the familial occurrence of AS, but it shows the occurrence to be lower than that previously reported.
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PMID:A family study of ankylosing spondylitis. 633 95

During the last 50 years there has been an obvious change in the relationship between Reiter's syndrome and spondarthritis, probably due to the introduction of antibiotics. Postgonorrhoeic prostatovesiculitis was formerly common: Romanus' spondylitics in the 1940s had a history of gonorrhoea in 35% of cases and 50% of my patients with chronic uro-arthritis in the 1950s had had gonorrhoea. Urogenital syndromes nowadays rarely develop into ankylosing spondylitis; on the other hand, sacroiliitis is still a rather common late sequela, especially in females, however often asymptomatic. The HLA-B27 tissue type is much less frequent in the urogenital syndromes than in ankylosing spondylitis. Accordingly one may postulate that patients with HLA-B27 negative sacroiliitis run a small risk that the disease will progress to ankylosing spondylitis.
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PMID:Urogenital syndromes and spondarthritis. 636 Feb 90

A questionnaire relating to presence and nature of back pain was distributed to all 10,150 employees (59% men) of an industrial complex. The questionnaire was returned by 2892 subjects (65% men). Of these, 1880 (65% of responders or 19% of total) reported a history of back pain. One hundred twenty-four described their back pain as insidious in onset, persisting for at least three months, developing at less than 40 years of age, being associated with morning stiffness, and showing improvement with exercise. Three hundred sixty-seven subjects scored four of these five features. Pelvic radiographs of 342 persons were available for blind evaluation. Sixteen patients (12 men) were shown to have definite ankylosing spondylitis (Grade III or IV sacroiliitis or HLA B27-associated Grade II sacroiliitis). Only one of these persons was known to have spondylitis. The majority of these symptomatic patients had been seen by both medical and nonmedical practitioners.
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PMID:The prevalence and nature of back pain in an industrial complex: a questionnaire and radiographic and HLA analysis. 644 64

Of 12 patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) or sacroiliitis (SI), only 4 (32%) had HLA-B27. Family studies revealed 3 B27-negative relatives with AS, 1 with SI, 1 with SI and IBD, and 1 with IBD alone. HLA haplotypes did not segregate with disease. These data suggest a non-HLA linked genetic predisposition to IBD which also confers susceptibility to spondylitis, even in the absence of expression of bowel disease.
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PMID:The spondylitis of inflammatory bowel disease. Evidence for a non-HLA linked axial arthropathy. 645 May 95

An attempt has been made to improve diagnostic precision in a group of diseases associated with inflammation of the sacroiliac joints by using a 99mtechnetium stannous pyrophosphate bone scan. Inflammation of these joints is associated with osteoblastic activity and is reflected by an increase in the uptake of radionuclide, which can be precisely quantitated. The uptake was markedly above the range of normal in patients with active ankylosing spondylitis (AS), and also in a number of patients with possible AS, psoriasis, and Reiter's syndrome. However, patients with Grade 4 radiological changes of the sacroiliac joints frequently had normal scans. This technique may be useful in the early diagnosis of sacroiliitis, and the nosological implications of the changes in patients with Reiter's syndrome and psoriasis are of interest.
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PMID:Investigation of sacroiliac disease: comparative evaluation of radiological and radionuclide techniques. 651 87

In a retrospective study 10 cases (6 males, 4 females) of special disco-vertebral forms of ankylosing spondylitis were evaluated. In all cases radiographs showed bilateral sacroiliitis and destructive-sclerotic disco-vertebral lesions but hardly any syndesmophytes considered typical for ankylosing spondylitis. We found a rather striking diversity of morphologic changes caused by spondylodiscitis, polysegmental involvement, the simultaneous and successive appearance (in the cause of the disease) of shiny corner, as well as anterior spondylitis and spondylodiscitis. All cases had clinical and humoral signs of disease activity, and some even had extravertebral manifestations. Radiographs and clinical findings indicate that an inflammatory process causes the disco-vertebral lesions. The special forms of ankylosing spondylitis as described in this article are in accordance with the polymorphism frequently observed in this disease.
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PMID:[Special disco-vertebral forms of ankylosing spondylitis]. 652 16

Vertebral ankylosing hyperostosis (VAH) represents a chronic spinal disorder that is often difficult to differentiate both from the inflammatory involvement of the spine like ankylosing spondylitis (Bechterew--AS) and from several forms of spondylosis or paravertebral ossifications of psoriatic spondylitis. Shapiro (1, 2) observed a significantly higher frequency of HLA antigen B27 in 47 patients with VAH; but this observation could not be confirmed by other authors. In our group of 46 patients with VAH, most of them males, there were no X ray signs of sacroiliitis. Compared with 1210 healthy blood donors, no significant difference was observed in the distribution of 31 HLA antigens of A, B, C locus.
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PMID:HLA antigens in vertebral ankylosing hyperostosis (Forestier's disease). 660 64


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