Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We wish to present in this paper the main clinical, roentgenological and immunogenetic characteristics of our patients with the ankylosing spondylitis syndrome, who do not possess the HLA-B27 antigen. Of 553 patients permanently treated in the Ward for Rheumatic Diseases of the Medical Faculty in Zagreb, 16 patients (7 women and 9 men) have been found who do not have the HLA-B27 antigen. Their average age was 39.6 (men: 46; women: 33; range: 25-66) years. The diagnosis of ankylosing spondylitis had been made on the basis of the Rome criteria (1) and that of sacroiliitis on the criteria of Hart and Robinson (2). HLA antigens were determined on the peripheral blood lymphocytes using the microcytotoxic test according to Terasaki and McClelland (3).
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PMID:Ankylosing spondylitis syndrome in patients without HLA-B27. 660 65

Cervical osteophytes may be seen in diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, posttraumatic, postoperative, degenerative causes, cervical spondylosis, and infectious spondylitis. A cervical osteophyte is very rarely considered among the differentials for symptoms of dysphagia. C5-C6 as well as C6-C7 being a site of greater load-bearing and mobility, the propensity to form osteophytes is high, with a small osteophyte leading to local mass effect. A 42-year-old male patient presented with mild dyspnea and significant dysphagia since 8 months, accompanied by dysphonia, weight loss, and intermittent aspiration. Clinical examination including neurological examination was normal. A barium swallow showed that osteophytes were severely protruding and displacing the lower pharynx and the proximal esophagus anterosuperiorly. The patient underwent surgical removal of the osteophyte through Smith-Robinson approach. Complaints of dysphagia were significantly decreased in postoperative period. A thorough evaluation is necessary to rule out other causes of dysphagia. Surgical management of this uncommon condition might be considered after confirmation of the osteophyte to be the offending lesion as it has favorable clinical outcomes.
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PMID:Dysphagia in a Young Adult: Rare Case of Giant Cervical Osteophyte. 3218 Dec 7