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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors have studied 6 cases of systemic AA amyloidosis associated with ankylosing spondylitis. Renal failure occurred in all patients a mean of 19 years after the clinical onset of the rheumatic disease. Three patients progressed rapidly (between 3 months and 3 years) to end-stage renal failure. Such an outcome did not depend upon early onset of the renal impairment, degree of inflammation or treatment with colchicine. All patients were alive 2 to 10 years later, and this confirms a better prognosis than with AL amyloidosis. The utility of combining Wright's permaganate reaction with immunological methods to characterize the amyloid deposits was also confirmed. It is concluded that amyloidosis is a rare complication of ankylosing spondylitis and probably depends on a genetic predisposition. The possibility of amyloidosis should be kept in mind when proteinuria or renal failure appear in the course of ankylosing spondylitis.
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PMID:[Ankylosing spondylitis with type AA amyloidosis. 6 cases]. 297 71

In a four week double-blind crossover study, flurbiprofen 200mg daily was compared with naproxen 750mg daily in the management of 30 patients with ankylosing spondylitis. Both treatments were found to be very effective in alleviating pain and stiffness. No significant difference in efficacy was discernible between the two drugs. Side-effects were more frequent with flurbiprofen. A small, but significant, increase in renal excretion of beta-n-acetyl glucosaminidase occurred during treatment with both naproxen and flurbiprofen. Although previous surveys have not shown evidence of renal damage, further surveillance of renal function in patients receiving long term treatment with these preparations to exclude possible renal impairment would be prudent.
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PMID:A comparison of flurbiprofen with naproxen in ankylosing spondylitis. 700 49

A 43-year-old man with ankylosing spondylitis (AS) was admitted with proteinuria and renal insufficiency. Coincidental IgA nephropathy and secondary renal amyloidosis were diagnosed on renal biopsy. This is the first case reported of coincidental IgA nephropathy and renal amyloidosis as a cause of renal insufficiency in a patient with AS. Both entities should be considered in the diagnosis in a patient with AS and renal impairment. A careful study of the renal tissue including, Congo red stain and immunofluorescence studies is necessary to establish a correct diagnosis in these patients.
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PMID:Coincidental amyloid nephropathy and IgA glomerulonephritis in a patient with ankylosing spondylitis. 816 28