Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Musculoskeletal disease occurs in association with inflammatory bowel disorders including Crohn's disease and ulcerative colitis, as well as with Whipple's disease; with enteritis caused by Salmonella, Shigella, and Yersinia; and also following intestinal bypass surgery. Extraintestinal causes of musculoskeletal alterations include Laennec's and biliary cirrhosis and pancreatitis. Three types of musculoskeletal abnormalities are recognized in patients with inflammatory bowel diseases: peripheral joint arthritis, sacroiliitis and spondylitis identical to ankylosing spondylitis, and rarely, miscellaneous changes such as digital clubbing and hypertrophic osteoarthropathy.
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PMID:Enteropathic arthropathies. 243 70

Many metabolic and endocrine disorders have effects on the musculoskeletal system, either due to primary changes in bone and collagen or resulting in secondary arthritic and bone changes. Disorders of ossification include heterotopic ossification, diffuse idiopathic skeletal hyperostosis (DISH), and the spondyloarthropathies. The early stages of heterotopic ossification have been analyzed using immunohistochemical techniques to trace the distribution of noncollagenous proteins. Several radiographic features of DISH and ankylosing spondylitis were discussed, including rib hyperostosis and syndesmophytes. Hypertrophic osteoarthropathy with associated arthritis was described in seven patients with hepatic failure and transplantation. Remarkable improvement in arthritis followed transplantation. The inverse relationship between osteoarthritis and osteoporosis continues to be studied, and it has been hypothesized that genetics play a major role in determining the rate of bone turnover, resulting in, for example, "bone formers." Both growth hormone excess and deficiency lead to changes in the incidence of osteoarthritis. Finally, one study documented the improved outcome in joint replacements in hemophiliac patients.
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PMID:Metabolic and endocrine disease and arthritis. 754 15

Rheumatological manifestations in inflammatory bowel disease (IBD) are frequent and include peripheral arthritis, axial involvement and peripheral enthesitis. Secondary osteoporosis and hypertrophic osteoarthropathy may also occur. Complications of IBD (e.g. septic arthritis) must be distinguished from sterile inflammation. Adverse effects of corticosteroid treatment, such as osteonecrosis, may also affect joints. Axial involvement ranges from low back pain to true ankylosing spondylitis. Human leukocyte antigen B27 is associated with axial involvement of IBD. Peripheral arthritis has been classified into two types. Type I is a pauciarticular, asymmetric usually non destructive arthritis affecting large joints and is usually associated with active bowel disease. Type II is a polyarthritis affecting small joints and tends to run a course independent of the bowel disease. Treatment of joint symptoms in IBD include sulphasalazine, azathioprine, methotrexate and glucocorticoids. Anti-tumor necrosis factor antibodies are effective in treating resistant or complicated Crohn's disease as well as peripheral arthritis and axial involvement.
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PMID:Rheumatological manifestations in inflammatory bowel disease. 2471 17