Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six patients (4 male and 2 female) presenting with an original, predominantly osseous disease are reported. The disease is characterized by a chronic inflammatory process affecting the thorax, the spine, the femur in 1 case and in all patients only one of the sacro-iliac joints. The condition had begun 11 to 28 years previously and had been active for 6 to 24 years. One case started with regressive polyarthritis. There was no visceral involvement. Radiograms showed bone condensation with hyperostosis, sometimes hypertrophic, unrelated to any articular space. Depending on each patient, the lesions involved the clavicles, the sternum, the posterior arch of the ribs, the vertebrae, the inferior femoral metaphysis. The only joints involved were the sacro-iliac and anubrio-sternal joints. The areas affected showed high radioisotope uptake. There was discrete biochemical inflammatory syndrome. Three of the 6 patients belonged to the HLA group B 27. The multiple biopsies performed showed no specific lesions. The disease proceeds by successive attacks lasting several months and responding poorly to anti-inflammatory drugs. One patient developed Crohn's disease, another, retroperitoneal fibrosis. In some respects, this condition is remindful of sterno-clavicular hyperostosis and of the osteo-arthropathy in palmoplantar pustulosis or acne conglobata. It seems to constitute a new variety of spondylo-arthropathy intermediate between the above-mentioned diseases and genuine ankylosing spondylitis.
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PMID:[Multiple hyperostosis with unilateral sacroiliitis. A new spondyloarthropathy]. 623 96

Auranofin is the first oral gold therapy known to be effective at relatively low toxicities. Extensive clinical trials in rheumatoid arthritis have recently been complemented by first experiences in juvenile chronic polyarthritis. For the time being, the drug should, therefore, be confined to these conditions. It is not indicated in ankylosing spondylitis and in other seronegative arthropathies. Indications mainly include failure of antimalarials, early erosive arthropathies and contraindication of injection therapy. The drug may also be used as an alternative to intramuscular gold, but should not be administered to responders to other chronic antirheumatics and in late or end-stage disease.
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PMID:[Experiences to date with oral gold therapy]. 644 52

At the current state of the art a comparison of gold salts and other therapeutic modalities in terms of their risk-benefit ratios clearly shows chrysotherapy to have a place in the treatment of active rheumatoid arthritis. Factors supporting the use of gold salts as base-line drugs for active rheumatoid arthritis include the extensive experience accumulated with chrysotherapy as a basic antirheumatoid treatment and the potential of gold salts to halt joint destruction. The application of gold salts in the treatment of juvenile chronic polyarthritis and psoriatic arthritis rests on the same rationale. Further studies are needed to establish the place of gold salts in ankylosing spondylitis and chronic Reiter's syndrome. Contraindications include diseases of organs likely to be the site of disastrous side effects on gold administration as well as disseminated lupus erythematosus and arthritis in the presence of colitis. Experiences with systemic gold therapy will, no doubt, be expanded in many a respect by the availability of an oral dosage form. Whatever the indication of gold salts a thorough understanding of clinical rheumatology, a complete mastery of the technique and consistent, meticulous patient monitoring are paramount if treatment is to be beneficial.
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PMID:[Indications and contraindications for systemic gold therapy]. 644 54

The prevalence of sacroiliitis was assessed clinically and radiologically in 261/323 1st degree relatives of 47 B27 positive probands who had ankylosing spondylitis (AS). Of the 151 relatives who were B27 positive, 23 had bilateral sacroiliitis (asymptomatic in 4), 2 had had Reiter's syndrome (RS) and 3 acute anterior uveitis (AAU). Similar assessment of 148/182 relatives of 34 B27 positive patients without demonstrable sacroiliitis (including 15 who had had RS and 11 AAU) showed 84 to be B27 positive. Only 1 had sacroiliitis, 2 had RS, 2 AAU and 2 chronic polyarthritis. Features of this study important in determining prevalence are the relatively high completion rate and the concurrent blind reading of radiographs of both B27 positive and negative subjects. AS is found in some B27 positive families, but not in others.
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PMID:The risk of sacroiliitis in B27 positive persons: a reappraisal. 661 Jul 56

In this report we present 21 instances in which live rubella virus was isolated from synovial fluid obtained from 6 cases of inflammatory oligoarthritis or polyarthritis over a period of 2 years in the absence of firm clinical evidence of rubella. In 3 cases (cases 1, 2, 6,) a persistent oligoarthritis predominantly affecting the knee joints occurred in 2 adult women and one man, lasting to date 27, 29, and 18 months respectively, and in one of these cases virions were found in cells of the synovial membrane. In case 3 a boy of 9 presented with an illness indistinguishable from the systemic variety of juvenile chronic arthritis (Still's disease). In case 4 a young man with persistent monoarthritis was found to have ankylosing spondylitis, and in case 5 a progressive erosive polyarthritis developed 5 years after an attack of rubella complicated by rubella arthritis. The virus was identified by a variety of virological techniques and infection confirmed by immunofluorescence and (in one case) electron microscopy.
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PMID:Chronic arthritis associated with the presence of intrasynovial rubella virus. 683 Mar 22

Synovial fluid studies have been made on 43 patients with rheumatic disease. Lymphocytes separated by a 2-stage procedure were examined for the presence of activated large lymphoid cells or immunoblasts. Such immunoblasts were found in 19 of 21 patients with classical rheumatoid arthritis and 7 of 10 patients with seronegative polyarthritis, including patients with Still's disease, psoriatic arthritis, and ankylosing spondylitis. No immunoblasts were seen in synovial fluid from osteoarthrosis or in the inflammatory but nonimmune synovial fluid from crystal-induced arthritis. The presence of immunoblasts showed a correlation with the lymphocyte count in the synovial fluid but not with the total white cell count. Preliminary studies confirm the spontaneous metabolic activity of these cells by autoradiography and show them by scanning electron microscopy to have a villous surface membrane. Simultaneous peripheral blood studies showed a lower incidence of immunoblasts than in the synovial fluid. It is suggested that these cells originate in the synovial membrane. In view of the known migration characteristic of immunoblasts these cells may be important in the spread of immune arthritis as well as being markers of disease activity.
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PMID:Immunoblasts in synovial fluid and blood in the rheumatic diseases. 696 65

A review of the clinical and immunological features of 72 children with chronic arthritis revealed a similar pattern of disease in Australian children when compared with overseas studies. Most of the children had pauciarticular disease, but polyarthritis and systemic forms were seen. Although HLA=B27 was identified in some patients, no florid example of ankylosing spondylitis in childhood was seen. A small, but significant, number of children had evidence of potentially blinding iritis which developed insidiously, and one child had acute uveitis. Although elevated antistreptolysin-O titres and raised total IgM levels were seen in a significant number of children, they were not confined to any particular clinical pattern and were not of any major prognostic value. Half the children were severely incapacitated at the height of their disease, but follow-up for periods of up to five years revealed that fewer than 5% had a significant permanent disability.
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PMID:Juvenile chronic arthritis. 697 22

In a family with 3 cases of acute anterior uveitis (AAU) the proband had 13 episodes of recurrent AAU associated 4 times with severe, throbbing ipsilateral headache. During one such episode he had an oculomotor palsy, hyperaesthesia of the cornea, and lack of spontaneous pulsations of the central retinal vein in the eye with AAU. An oculomotor palsy occurred twice intermittently between the AAU episodes. Carotid and vertebral angiographies confirmed the diagnosis of ophthalmoplegic migraine. Prostaglandins liberated by trauma, AAU, or other inflammation may be involved as mediators in ophthalmoplegic migraine attacks. All 3 patients with AAU had sacroiliitis and seronegative polyarthritis. One of their siblings had polyarthritis and one incomplete Reiter's disease. All of them were HLA-B27 positive whereas one healthy sibling was HLA-B27 negative. These findings support the hypothesis that HLA-B27 itself or a pleiotropic HLA-B27 linked gene predisposes the carrier to AAU, sacroiliitis, ankylosing spondylitis, and Reiter's disease.
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PMID:Association of ophthalmoplegic migraine with familial acute anterior uveitis. 698 75

The studies of histocompatibility (HLA) antigens have contributed to the understanding of the pathogenesis of uveitis. Acute anterior uveitis is associated with rheumatic disorders such as ankylosing spondylitis. HLA-B 27 antigen is present in 98% of these cases. There are genetic and environmental factors influencing the activity of the disease. HLA-B 27 was found to be associated with 43% of cases of acute anterior uveitis without systemic disease. In juvenile chronic polyarthritis with acute anterior uveitis HLA-B 27 helps in differentiating between ankylosing spondylitis and Still's disease. Specific HLA antigens were also found in other forms of uveitis such as Reiter's disease (HLA-B 27), Behcet's syndrome (HLA-B 5), VKH syndrome (HLA-Bw 22J) and ocular histoplasmosis (HLA-B 7). Despite these new findings, there are still many obscure factors and further studies are required to elucidate the pathogenesis of uveitis and to achieve its prevention.
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PMID:Histocompatibility antigens (HLA) and uveitis. 698 62

Total-dose iron-dextran infusions have been reported to cause exacerbation of the disease in patients with rheumatoid arthritis and ankylosing spondylitis. A case of prolonged polyarthritis following a total-dose iron-dextran infusion in a patient with no evidence of rheumatoid arthritis or ankylosing spondylitis is reported.
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PMID:Development of an inflammatory synovitis following total-dose infusion of iron-dextran. A case report. 708 6


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