Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventy-four hospitalized patients with ankylosing spondylitis (HOSP AS) were compared clinically with 27 AS patients found in an epidemiological study (EPI AS). The distribution of radiographic changes, initial symptoms and age at onset of AS, frequency of HLA-B27 and acute anterior uveitis were similar in the 2 groups. The EPI AS patients had less restricted spinal and chest mobility than the hospitalized patients. Restriction of mobility thus appears to be an important factor for referral of patients with AS to hospital. A higher frequency of employment among EPI AS patients was found.
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PMID:Ankylosing spondylitis: a comparative study of patients in an epidemiological survey, and those admitted to a department of rheumatology. 652 Aug 33

The results of segregation analyses in 75 families where the proband had ankylosing spondylitis, are presented. Of the 278 adult, living first degree relatives, approximately 85% cooperated in the study. Clinical and radiographical examinations were performed and HLA typing was conducted. The results were in agreement with our hypothesis that ankylosing spondylitis is part of a syndrome where different genetic factors interact. Such known factors are HLA B27 associated disease susceptibility, susceptibility to psoriatic arthropathy and susceptibility to entero-arthropathy. Radiographical sacro-iliitis was restricted to HLA B27 positive relatives, and was more frequently found in relatives to probands with psoriasis than in relatives to probands without psoriasis. Environmental factors (intestinal bacteria) are known to trigger the disease at least in some persons, and we have postulated that all or most of them have the predisposition to develop disease. Thus, the syndrome has a multifactorial etiology. The phenotypic expressions of the different genetic predispositions involved, include sacro-iliitis, psoriasis, acute anterior uveitis, peripheral arthropathy and inflammatory bowel disease. We suggest the descriptive name HEREDITARY MULTIFOCAL RELAPSING INFLAMMATION (HEMRI) for this syndrome. Ankylosing spondylitis, psoriatic arthropathy and entero-arthropathy may be regarded as clinical sub-types of the syndrome.
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PMID:Family studies in Bechterew's syndrome (ankylosing spondylitis) III. Genetics. 660 2

Of the first degree relatives of B27 positive spondylitis probands, 10.2% demonstrated an associated disease, i.e., ankylosing spondylitis, Reiter's syndrome, peripheral arthritis, or acute anterior uveitis; all were B27 positive. Eighteen, i.e., only 13.7% of the B27 positive subjects had sacroiliitis; 4 were asymptomatic. We would therefore caution against the previous over-estimation of disease prevalence in "randomly selected" HLA-B27 positive individuals. None of the B27 negative relatives had any uveitis or spondyloarthropathy.
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PMID:Ankylosing spondylitis: a family study. 660 14

HLA-B27 typing of 103 acute anterior uveitis (AAU) patients showed that 49 (48%) were positive for this antigen. Of these HLA-B27 positive AAU patients, 27 (55%) had ankylosing spondylitis (AS) according to the New York criteria. The 22 HLA-B27 positive AAU patients without AS, however, also showed symptoms and signs of AS. Seventeen (77%) of these 22 HLA-B27 positive AS negative AAU patients fulfilled a set of criteria for classification as possible AS. In the group of 54 HLA-B27 negative AAU patients, only two patients (4%) had AS. Of the remaining 52 patients only seven (13%) had possible AS. Of the 21 patients having posterior uveitis (PU) none was HLA-B27 positive nor met the criteria for AS or possible AS. These findings indicate a strong relationship between AAU, AS or possible AS and HLA-B27 and suggest that HLA-B27 typing in AAU patients is important for early diagnosis of AS.
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PMID:Possible ankylosing spondylitis in acute anterior uveitis. 660 66

One hundred and sixty-nine patients, 82 with acute anterior uveitis (AAU) only, 48 with AAU and ankylosing spondylitis (AS), and 39 with AS only were studied. The HLA antigen A2 was present in 44/82 AAU only, 31/48 AAU + AS, and 23/39 AS only. Where haplotype analysis was possible by virtue of family studies, A2 B27 was present in 7/16 AAU only, 9/15 AAU and AS and 14/29 AS only. These figures do not differ significantly from the expected values of control populations. Alpha-1-antitrypsin (alpha-1-AT) phenotypes were obtained on 30/82 AAU only, 29/48 AAU + AS, and 27/39 AS only patients. The MZ phenotype appeared in 8/86 patients tested; 4/30 with AAU only and 4/29 AAU + AS patients. This is higher than the expected value for control populations. Therefore, MZ alpha-1-AT phenotype but not HLA-A2 appears increased in patients with AAU.
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PMID:Genetic markers for acute anterior uveitis. 660 43

The prevalence of sacroiliitis was assessed clinically and radiologically in 261/323 1st degree relatives of 47 B27 positive probands who had ankylosing spondylitis (AS). Of the 151 relatives who were B27 positive, 23 had bilateral sacroiliitis (asymptomatic in 4), 2 had had Reiter's syndrome (RS) and 3 acute anterior uveitis (AAU). Similar assessment of 148/182 relatives of 34 B27 positive patients without demonstrable sacroiliitis (including 15 who had had RS and 11 AAU) showed 84 to be B27 positive. Only 1 had sacroiliitis, 2 had RS, 2 AAU and 2 chronic polyarthritis. Features of this study important in determining prevalence are the relatively high completion rate and the concurrent blind reading of radiographs of both B27 positive and negative subjects. AS is found in some B27 positive families, but not in others.
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PMID:The risk of sacroiliitis in B27 positive persons: a reappraisal. 661 Jul 56

Fifty-one North Indian patients with ankylosing spondylitis (AS) are described with mean age of onset 21.2 years and male to female ratio of 16:1. AS began with peripheral arthritis in 47%, low back pain in 41%, acute anterior uveitis in 10%, and heel pain in 2% of the patients. 76% of 51 patients had one of the extra-axial features of AS: peripheral arthritis (61%), heel pain (24%), anterior uveitis (22%), urethritis (12%), kidney disease (10%), mucosal ulcerations (6%), aortic incompetence (4%), and apical pulmonary fibrosis (4%). A majority (71%) of the patients with peripheral arthritis had mono- or oligoarthritis affecting mainly the lower limb joints. Two patients had coexistent rheumatoid arthritis also. HLA-B27 antigen was detected in 48 (94%) of 51 patients compared with 7 (6%) of 118 controls (relative risk 254; Fisher's exact p = 3.49(-29]. On comparing patients with juvenile onset AS and patients with adult onset disease we found peripheral arthritis to be more frequent at the beginning and during the course of disease in the former.
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PMID:Ankylosing spondylitis in North India: a clinical and immunogenetic study. 661 Nov 38

Patients hospitalized for psoriasis, acute anterior uveitis, ankylosing spondylitis or with chronic prostatis were examined. From previous reports and our own results we formulated hypotheses of the genetic mechanisms involved. We then examined all available adult relatives of 75 patients with ankylosing spondylitis. Our previously established genetic hypotheses were tested by segregation analyses in these families. All our results point to the existence of a syndrome of distinct but interacting genetic factors. The main factor is the HLA-B27 associated disease predisposition. Manifestation of this predisposition seems to be influenced by sex and by presence of factors coding for psoriasis and/or psoriatic arthropathy. Our results concerning psoriasis and psoriatic arthropathy supported the previous suggestions that these diseases exhibit genetic heterogeneity. It is known that disease signs may be triggered by infection in genetically predisposed persons. The syndrome therefore has a multifactorial aetiology. Seronegative arthropathy is a term that includes all arthritic components of the syndrome. There is a need for a term that encompasses all clinical signs of the genetic factors involved. We propose 'Hereditary multifocal relapsing inflammation' (HEMRI) as a descriptive term for this syndrome. The disease entities included may be regarded as subtypes of the syndrome.
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PMID:Seronegative arthropathy and associated diseases--a multigenic syndrome? 668 76

HLA antigen frequencies in 53 unrelated Asian Indian patients with acute anterior uveitis, with or without associated spondyloarthropathies, were compared with our published data on American Whites and Blacks. The most frequent HLA phenotype among uveitis patients with associated ankylosing spondylitis was A9(W24), B27 in Asian Indians as compared to A2, B27 in the American Whites and Blacks.
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PMID:HLA antigens in acute anterior uveitis and spondyloarthropathies in Asian Indians and their comparison with American whites and blacks. 668 12

Using an indirect immunoperoxidase technique we found the numbers of IgG-containing cells in the rectal lamina propria to be increased in patients with ankylosing spondylitis compared with controls, but not in patients with acute anterior uveitis or rheumatoid arthritis, or in the first-degree relatives of patients with ankylosing spondylitis. No differences between diagnostic groups were detected in the numbers of cells containing IgA, IgM, IgD, or IgE. The total numbers of plasma cells in the rectal lamina propria were not significantly increased. Similar increases of IgG-containing cells were not found in the duodenal lamina propria of patients with ankylosing spondylitis.
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PMID:Increased numbers of IgG-containing cells in rectal lamina propria of patients with ankylosing spondylitis. 671 91


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