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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The frequency of cardiac conduction disturbance in ankylosing spondylitis is discussed. Risk of such disturbance in the patients' relatives is, to our knowledge, not known. To examine these problems, ECG records of 99 patients with ankylosing spondylitis and 132 of their adult first degree relatives were obtained. P-R intervals were determined by standardized methods and compared with P-R intervals of the controls. The distribution of P-R intervals both in the patients and their relatives was close to the controls'. Four cases of first degree AV block were found among the patients (P-R intervals 0.21-0.26 sec), one of them had aortic valve insufficiency. The single case of pronounced conduction delay (P-R interval 0.42 sec) was recorded in an otherwise healthy HLA B27-positive relative. One male secondary case of ankylosing spondylitis had a P-R interval of 0.22 sec. Patients who had experienced acute anterior uveitis had relatively long P-R intervals, while patients with psoriasis had relatively short P-R intervals. The conclusion was that cardiac conduction disturbance was not frequent in patients with ankylosing spondylitis or in their relatives.
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PMID:Atrioventricular conduction time in ankylosing spondylitis. Distribution of P-R intervals in patients and their relatives. 387 14

Forty-four females and 82 male patients with ankylosing spondylitis (AS) were compared in a retrospective study. No differences were found with respect to age at onset of disease, initial symptoms, work performance or peripheral joint involvement. Furthermore, males and females did not differ in restriction of spinal mobility, chest expansion, frequency of acute anterior uveitis or mean concentration of IgA. Males had significantly higher frequency of elevated C-reactive protein whereas mean erythrocyte sedimentation rate showed no such difference.
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PMID:A clinical comparison between males and females with ankylosing spondylitis. 387 66

Ten consecutive patients with juvenile ankylosing spondylitis were investigated in a prospective study. At least one of the parents of each patient had a positive history of probable or definite ankylosing spondylitis, Reiter's syndrome, or acute anterior uveitis. The patients and their parents were examined clinically and were HLA-typed. Nine of the 10 patients exhibited the genetic marker HLA B27, but only one patient was homozygous for HLA B27. This prevalence of homozygosity among HLA B27 positive persons could be expected to occur by chance alone. Based on the limited material studied, we cautiously conclude that HLA B27 homozygosity is probably not responsible for disease onset in childhood.
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PMID:Juvenile ankylosing spondylitis and HLA B27 homozygosity. 387 92

One hundred and twenty-two hospitalized patients, 35 years or more of age with confirmed bilateral sacro-iliitis and 239 first-degree relatives, 25 years or more of age, were examined. All but 3 of the patients had confirmed ankylosing spondylitis (AS) in accordance with established criteria. The sacro-iliac joints were scored by a recently developed grading system. The prevalence of grade V sacro-iliits--extensive ankylosis--was greater in HLA B27-positive than in HLA B27-negative patients, and ankylosis of apophyseal joints, ossification of the interspinous ligament, or block vertebrae were not seen in HLA B27-negative patients. Shining corners and/or squared vertebrae were the most frequent findings of the dorsolumbar spine in patients with a disease course of less than 10 years. Mixed osteophytes were rare in patients below 40 years of age. All radiographic inflammatory changes scored in the spine-except for shining corners--were most often seen in patients with a disease history exceeding 20 years. Syndesmophytes and/or ankylosed apophyseal joints were less extensive in female than in male patients. No differences in the severity of radiographic changes in sacro-iliac joints or in frequency, severity or localization of different radiographic changes of the dorsolumbar spine were observed between HLA B27-positive patients with and those without psoriasis or acute anterior uveitis. Definite sacro-iliitis was restricted to HLA B27-positive relatives of HLA B27-positive probands and demonstrated in one-fifth of them. Shining corners and/or squared vertebrae were frequent findings in relatives with sacro-iliitis (45%), whereas apophyseal joint ankylosis, ossification of the interspinous ligament, block vertebrae and bridging syndesmophytes were not seen. Our results support the view that AS is not a defined disease entity and should be regarded as a syndrome. AS is an improper name for all patients fulfilling the Rome and/or New York criteria for definite AS, since many of them will probably never develop ankylosis of the spine or sacro-iliac joints.
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PMID:Radiographic evaluation of patients with Bechterew's syndrome (ankylosing spondylitis) and their first-degree relatives. Findings in the spine and sacro-iliac joints and relations to non-radiographic findings. 387 98

The immune response appears to be partially regulated by genes linked to the IgGH chain gene complex. Immunoglobulin allotypic markers Gm groups are distributed in Caucasians largely in 5 relatively well defined phenotypes. We examined the prevalence of these phenotypes in 119 patients with ankylosing spondylitis, Reiter's syndrome or acute anterior uveitis. No significant deviation from the control frequencies was noted.
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PMID:Immunoglobulin allotypes in patients with ankylosing spondylitis, Reiter's syndrome and acute anterior uveitis. 404 50

One hundred and sixty-nine patients with acute anterior uveitis were studied for the presence of HLA-B27 tissue type, radiological evidence of ankylosing spondylitis, and a history of back pain. 60% were male; 45% were HLA-B27+. The male:female ratio in the HLA-B27+ group was the same as in the whole group. 24% had radiological evidence of ankylosing spondylitis, and, of these, 83% were HLA-B27+ while 17% were HLA-B27-. There was a definite correlation between the severity of the ankylosing spondylitis and preponderance of males in the HLA-B27+ group of patients. Significant back pain occurred in 60% of HLA-B27+ patients but in only 14% of HLA-B27- patients. The importance of the selection of patients and of consistency in the use of diagnostic criteria in studies relating to ankylosing spondylitis and acute anterior uveitis is stressed.
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PMID:Acute anterior uveitis, ankylosing spondylitis, back pain, and HLA-B27. 623 42

Pi phenotypes were determined in patients hospitalized with ankylosing spondylitis, acute anterior uveitis, psoriasis or chronic prostatitis. The allele frequencies were calculated. No deviation in allele frequencies from Norwegian controls could be demonstrated.
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PMID:Pi phenotypes in patients with ankylosing spondylitis, acute anterior uveitis, psoriasis and chronic prostatitis. 633 42

We studied immunoglobulin Gm and Km allotypes in 54 patients with HLA-B27-positive anterior uveitis and in 204 healthy controls. No differences were noted between the two groups. Dividing the patients with anterior uveitis into those with ankylosing spondylitis (No. = 22) and those without it (No. = 32), produced interesting results. The Gm 1, 3, 17; 23; 5, 13, 21 phenotype was significantly (P = .007) increased in those within the ankylosing spondylitis and anterior uveitis group. Of these 22 patients, ten (45.5%) carried the Gm 1, 3, 17; 23; 5, 13, 21 phenotype compared to two of 32 (6.3%) in those with anterior uveitis alone and 33 of 204 (16.2%) normal controls. There were no significant differences between patients and controls in the frequencies of the other phenotypes tested.
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PMID:Association of Gm allotypes with the occurrence of ankylosing spondylitis in HLA-B27-positive anterior uveitis. 633 44

Serum and EDTA blood from 120 patients with ankylosing spondylitis (Bechterew's syndrome) and serum from 138 first-degree relatives of patients and from 42 adult blood donors were investigated. Increased serum concentrations of IgA and IgG and complement factors C3 and C4 were found in total groups of HLA B27-positive male or female patients compared with controls or relatives. The men had higher serum concentration of IgA and complement factors than the women, whereas IgM concentration was higher in the women. These patterns were found in controls, in relatives and in patients. Increased concentrations of IgA and of C4 were characteristic of all patients whereas IgG and IgM and C3 concentrations were likewise elevated in patients with peripheral joint arthritis/arthropathy. Increased levels of circulating immune complexes (CIC) were associated with peripheral joint arthritis and were strongly correlated with IgG or CRP concentrations in serum. Total haemolytic complement activity in serum was negatively correlated with concentrations of CIC or CRP indicating complement activation in patients with such complexes. No differences in serum concentrations of Ig or complement factor concentrations were seen between HLA B27-positive and negative relatives with normal sacro-iliac joints or between relatives and controls. Strong mutual correlations were seen among IgG, IgM, complement factors, CRP, SAA, sedimentation rate and alpha 2-macroglobulin. When the present findings were combined with our previous results it turned out that AS, and psoriasis with or without arthropathy, and acute anterior uveitis (AAU) in combination with sacro-iliitis, may be described as IgA-related conditions and that increased serum C4 was related to sacro-iliitis in all these disorders.
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PMID:Immunological variables and acute-phase reactants in patients with ankylosing spondylitis (Bechterew's syndrome) and their relatives. 633 23

Samples of the faeces of 153 consecutive patients presenting with acute anterior uveitis (AAU), and of 47 controls were examined for the presence of Klebsiella pneumoniae. No increase in the carriage rate of klebsiella was found in the AAU patients as compared with the controls. Furthermore no increase was found in any group of patients whether subdivided by HLA-B27 status, sex, or presence of ankylosing spondylitis (AS). No difference was found between patients having their first attack of AAU and those with recurrences.
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PMID:Klebsiella and acute anterior uveitis. 639 34


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