Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ossification of the posterior longitudinal ligament (OPLL) is most commonly found in men, the elderly, and Asian patients. There are many diseases associated with OPLL, such as diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, and other spondyloarthropathies. Several factors have been reported to be associated with OPLL formation and progression, including genetic, hormonal, environmental, and lifestyle factors. However, the pathogenesis of OPLL is still unclear. Most symptomatic patients with OPLL present with neurological deficits such as myelopathy, radiculopathy, and/or bowel and bladder symptoms. There are some reports of asymptomatic OPLL. Both static and dynamic factors are related to the development of myelopathy. Plain radiography, CT, and MR imaging are used to evaluate OPLL extension and the area of spinal cord compression. Management of OPLL continues to be controversial. Each surgical technique has some advantages and disadvantages, and the choice of operation should be made case by case, depending on the patient's condition, level of pathology, type of OPLL, and the surgeon's experience. In this paper, the authors attempt to review the incidence, pathology, pathogenesis, natural history, clinical presentation, classification, radiological evaluation, and management of OPLL.
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PMID:Ossification of the posterior longitudinal ligament: a review. 2143 17

Eight men with Andersson lesions associated with ankylosing spondylitis who underwent surgical treatment were reviewed for this study. Eight Andersson lesions were found in the 8 patients, and all presented as pseudoarthrosis. Including a patient with obvious vertebral body destruction, no obvious local kyphosis was observed. Spinal cord compression and neural deficit were observed in 1 patient. Without established instructions for the surgical treatment of Andersson lesions, we alternated the surgical technique for each patient. Therefore, 5 patients, including the patient with obvious anterior destruction requiring reconstruction, underwent surgical treatment with lesion curettage and anterior bone graft and fusion; 3 other patients underwent surgical treatment without lesion curettage and anterior bone graft. All surgeries were performed from a posterior approach. Posterolateral autograft was supplemented to posterior instrumentation with or without anterior bone graft.All 8 patients experienced pain relief immediately postoperatively. No evidence of non-union was observed on radiographs at the level of pseudoarthrosis at final follow-up, and no neural and infectious complications were observed. Based on these results, surgical treatment with only posterior instrumentation supplemented by posterolateral autograft was effective for patients with Andersson lesions without obvious vertebral body destruction requiring reconstruction. Anterior lesion curettage and bone graft were not necessary. Solid immobilization, achieved by posterior instrumentation, should be the focus of the treatment of Andersson lesions with ankylosing spondylitis.
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PMID:The surgical treatment of Andersson lesions associated with ankylosing spondylitis. 2171 94

Kyphosis is a difficult topic of spinal surgery, and its management contains many controversies. Surgical management needs consideration of different aspects of the kyphotic deformity such as neurological status, the presence of spinal cord compression, angle of the kyphosis, the quality of bone, and accompanying diseases. In case of significant cord compression and neurological compromise, anterior surgery should have the priority. However, in smooth-angled kyphosis and ankylosing spondylitis patients, deformity can easily be reduced by a posterior-only approach. Since they have no neurological deficits, and large spinal canals, most suitable patients for pedicle subtraction osteotomy are the patients with ankylosing spondylitis.In lumbar kyphosis one-level pedicle subtraction osteotomy (especially at L2 or L3 levels), in thoracic kyphosis multilevel osteotomies, and in cervicothoracic kyphosis an osteotomy at C7-T1 level should be preferred.Pedicle subtraction osteotomy is a technically demanding procedure that requires surgeons to perform meticulous technique and consider biomechanical issues to achieve satisfactory results and avoid complications. An attempt to correct the rigid fixed spinal deformity is a difficult task and requires the capability of a highly experienced spine surgeon. Although the physical outcome and patient satisfaction of surgical treatment is quite good, risks and complications should always be considered by both the physician and patient.
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PMID:Surgery for kyphosis. 2430 21

X linked hypophosphataemia (XLH) is a rare condition with numerous musculoskeletal complications. It may mimic other more familiar conditions, such as vitamin D deficiency, ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis. We describe two cases with Chiari type 1 malformations and syringomyelia, neither of which is well recognised in XLH. The first presented late with the additional complications of spinal cord compression, pseudofracture, renal stones and gross femoroacetabular impingement requiring hip replacement. The second also had bulbar palsy; the first case to be described in this condition, to the best of our knowledge. We wish to raise awareness of the important neurological complications of syringomyelia, Chiari malformation, spinal cord compression and bulbar palsy when treating these patients. We also wish to draw attention to the utility of family history and genetic testing when making the diagnosis of this rare but potentially treatable condition.
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PMID:Chiari malformation, syringomyelia and bulbar palsy in X linked hypophosphataemia. 2656 Dec 26

Spinal cord injuries (SCIs) are sustained by more than 12 500 patients per year in the United States and more globally. The SCIs disproportionately affect the elderly, especially men. Approximately 60% of these injuries are sustained traumatically through falls, but nontraumatic causes including infections, tumors, and medication-related epidural bleeding have also been documented. Preexisting conditions such as ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis can render the spine stiff and are risk factors as well as cervical spondylosis and ensuing cervical stenosis. Treatment options vary depending on the severity, location, and complexity of the injury. Surgical management has been growing in popularity over the years and remains an option as it helps reduce spinal cord compression and alleviate pain. Elevating mean arterial pressures to prevent spinal cord ischemia and avoiding the second hit of SCI have become more common as opposed to high dose steroids. Ongoing clinical trials with pharmacological agents such as minocycline and riluzole have shown early, promising results in their ability to reduce cellular damage and facilitate recovery. Though SCI can be life changing, the available treatment options have aimed to reduce pain and minimize complications and maintain quality of life alongside rehabilitative services.
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PMID:Spinal Cord Injury in the Geriatric Population: Risk Factors, Treatment Options, and Long-Term Management. 2854 Jan 18


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