Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Systemic diseases as rheumatoid arthritis and ankylosing spondylitis have unknown etiologies, unclear pathogenic mechanisms and multiorgan involvements. Ocular involvement is variable and may effect several levels: sclera, cornea, uvea and conjunctiva. Because an ocular event signify an enhancement of inflammatory-immune reactions, the patient may undergo a complete investigation and general therapy must complete local treatment. The paper showing the ocular manifestation in patients with rheumatic arthritis through a ten-years period.
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PMID:[The ocular manifestations in rheumatoid polyarthritis]. 1064 Oct 82

We, in this study, report a 72-year-old woman presenting with premature osteoarthritis of the spine, the hips, the knees and the shoulders symptomatic since the age of 50 years. The initial presentation of backache led to a mistaken diagnosis of ankylosing spondylitis. Subsequent manifestation of characteristic discoloration of her sclera and overnight dark urine led to the correct diagnosis of ochronosis.
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PMID:Premature arthritis in an elderly woman. 1685 58