Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although heterotopic ossification following total hip arthroplasty is frequently observed radiographically, it fortunately is much less commonly of clinical importance. There are, however, a group of patients that develop significant heterotopic bone formation, which can be symptomatic and, in some cases, can require repeat surgery. Careful surgical technique seems indicated in all patients undergoing total hip arthroplasty to try to reduce the incidence of this problem. Patients who are recognized to be at risk should be treated with prophylaxis. These include patients with active ankylosing spondylitis, skeletal hyperostosis, and prior heterotopic bone formation. Both low-dose radiation and nonsteroidal anti-inflammatories have been shown to be effective. The choice between these two modalities depends on the patient's individual circumstances, the availability of radiotherapy support (including custom shielding for ingrowth components), and the presence of areas of bone grafting and any osteotomies or fractures. Nonsteroidal anti-inflammatories, particularly Indomethacin, are a very acceptable form of prophylaxis and may be preferred in certain patients, including young women of childbearing age. Radiation is preferred in those patients with known GI intolerance to these medications or with a prior history of peptic ulcer disease. Excision of heterotopic bone, if symptomatic, should not be performed before 6 to 12 months and then only once it is clear that the process is mature. Bone scans can be helpful in assessing the maturity of heterotopic bone and can guide the timing of excision. Prophylaxis should be carried out in all patients following excision of heterotopic bone.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Heterotopic ossification following total hip arthroplasty. 779 65

Salmon calcitonin (especially intranasal) provides an interesting analgesic effect in a series of painful conditions including reflex sympathetic dystrophy syndrome, adhesive capsulitis, ankylosing spondylitis, rheumatoid arthritis, vertebral crush fractures and metastasis, phantom limb pain, etc. In addition, in preliminary series, calcitonin shows an unexpected benefit to vasomotor changes and peptic ulcer. Yet the experience in these conditions is limited and needs confirmation. By comparison with the injectable, the intranasal route seems particularly interesting because of less undesirable effects, and a more rapid and probably more powerful analgesia.
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PMID:Calcitonin in reflex sympathetic dystrophy syndrome and other painful conditions. 1200 65

A clinical evaluation of phenylbutazone and Butapyrin(R) (a mixture of phenylbutazone and aminopyrine) was made in 409 patients who had a variety of rheumatic diseases. Preliminary European claims were substantiated.In gout a specific favorable effect was brought about by phenylbutazone alone. Effects equivalent to the previously reported favorable response to Butapyrin (Irgapyrin) were observed when its constituent phenylbutazone was used alone. The drug had a suppressive effect in a high percentage of patients with rheumatoid arthritis, ankylosing spondylitis, arthritis with psoriasis and mixed arthritis (rheumatoid arthritis plus osteoarthritis). Favorable effect in peritendinitis of the shoulders, osteoporosis of the spine and acute lumbosacral strain also was noted. Toxicity resulted in discontinuance of medication in 10 per cent of patients with each drug. Manifestations of toxicity generally included fluid retention, nausea and rash, but there were several instances of transitory leukopenia and anemia. There was one instance of agranulocytosis with Butapyrin but none with phenylbutazone.dagger Aggravation of peptic ulcer occurred in ten patients with hemorrhage in two. Generally the toxicity was of a low order as compared with that of other drugs having an antirheumatic effect.
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PMID:Phenylbutazone (butazolidin) and butapyrin; a study of clinical effects in arthritis and gout. 1300 82

James Joyce, unanimously considered one of the greatest novelists of the 20th century, suffered from several diseases. A series of adverse circumstances progressively deteriorated his health, already precarious because of his very disorderly life habits. Aim of the present study is to summarize the various organic diseases Joyce suffered during his lifetime, as long as the main diagnostic conclusions found in scientific literature. Severe eye problems, caused by recurrent iritis attacks even complicated by glaucoma and cataracts, led him almost to blindness. Undernourishment and irregular eating, great anxiety and alcohol abuse were the major causes of the peptic ulcer which tortured him for many years, causing his final death. To these conditions should also be added dental caries, venereal diseases and recurrent polyarthritis. The hypothesis according which Joyce suffered from neurosyphilis is still debated and should be sufficiently demonstrated, whereas a spondyloarthropathy, either Reiter's syndrome or ankylosing spondylitis, appears more likely. Therapies against these diseases, easily treated today, did not result efficient because of his poor compliance, as well as the state of the art of medical science during his lifetime. A detailed paleopathologic study of Joyce's human remains could allow to solve the diagnostic doubts concerning his main disease.
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PMID:[Portrait of the artist as a sick man. Rheumatological pathography of James Joyce (1882-1941)]. 1865 Oct 61