Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vertebral ankylosing hyperostosis (VAH) represents a chronic spinal disorder that is often difficult to differentiate both from the inflammatory involvement of the spine like ankylosing spondylitis (Bechterew--AS) and from several forms of spondylosis or paravertebral ossifications of psoriatic spondylitis. Shapiro (1, 2) observed a significantly higher frequency of HLA antigen B27 in 47 patients with VAH; but this observation could not be confirmed by other authors. In our group of 46 patients with VAH, most of them males, there were no X ray signs of sacroiliitis. Compared with 1210 healthy blood donors, no significant difference was observed in the distribution of 31 HLA antigens of A, B, C locus.
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PMID:HLA antigens in vertebral ankylosing hyperostosis (Forestier's disease). 660 64

Neurologic complications due to spinal cord compression developed in a patient with diffuse, idiopathic skeletal hyperostosis (Forestier's disease) originally mistaken for ankylosing spondylitis. Emergency laminectomy stopped progression of the symptoms and resulted in slow improvement.
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PMID:Diffuse idiopathic skeletal hyperostosis (DISH) causing spinal stenosis and sudden paraplegia. 664 1

A patient with ankylosing hyperostosis (Forestier's disease) initially diagnosed elsewhere as a case of ankylosing spondylitis with bamboo spine, is presented. The characteristic roentgenographic findings of Forestier's disease in the axial skeleton of this patient are described, including computerized tomography of the lower lumbar spine and sacroiliac joints. Major clinical and radiological distinguishing features of Forestier's disease and ankylosing spondylitis are discussed.
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PMID:Confusion of roentgenographic differential diagnosis between ankylosing hyperostosis (Forestier's disease) and ankylosing spondylitis. 667 1

The case was a 51 years old male who died of cervical spinal cord injury. On admission, X-ray disclosed distinct hyperostosis such as ossification of posterior longitudinal ligament, ankylosing spondylitis and callus luxurians of bilateral hip joints. He had no familial history. He normally developed into adult without any mental and neurological abnormalities. In the latter half of the fifth decade, he developed progressive spastic diplegia of his legs. Laboratory studies revealed evident hypocalcaemia (2.3 meq/l). Hormonal examination of the parathyroid gland was not performed. Postmortem examination of the brain (1,400 g) disclosed widely spreading numerous spherical deposits of various sizes stained deeply with hematoxilin. These deposits were positive with PAS, colloidal iron, prussian blue and Kossa's Method for calcium etc. as shown in Table 1. According to their histochemical properties, these deposits were considered to consist of both acid mucopolysaccharides and proteins to which calcium and iron have been bound later. These deposits were predominantly observed in the basal ganglia, dorso-lateral portion of the thalamus and the depth of the cerebellum. The dentate nucleus was mostly spared. To the lesser degree, these deposits were also seen around the capillaries and subadventitial space of the small vessels in the cerebral cortex, cerebral white matter, capsula interna and red nucleus. These deposits were shown to be adjacent to the capillary walls microscopically. Electron microscopy disclosed that many electron dense spherical bodies surrounding capillary were related to the basement membrane of the endothelium or pericyte.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[An autopsy case of cerebral calcification--with special reference to the morphogenesis of the calcified deposits]. 673 85

Many metabolic and endocrine disorders have effects on the musculoskeletal system, either due to primary changes in bone and collagen or resulting in secondary arthritic and bone changes. Disorders of ossification include heterotopic ossification, diffuse idiopathic skeletal hyperostosis (DISH), and the spondyloarthropathies. The early stages of heterotopic ossification have been analyzed using immunohistochemical techniques to trace the distribution of noncollagenous proteins. Several radiographic features of DISH and ankylosing spondylitis were discussed, including rib hyperostosis and syndesmophytes. Hypertrophic osteoarthropathy with associated arthritis was described in seven patients with hepatic failure and transplantation. Remarkable improvement in arthritis followed transplantation. The inverse relationship between osteoarthritis and osteoporosis continues to be studied, and it has been hypothesized that genetics play a major role in determining the rate of bone turnover, resulting in, for example, "bone formers." Both growth hormone excess and deficiency lead to changes in the incidence of osteoarthritis. Finally, one study documented the improved outcome in joint replacements in hemophiliac patients.
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PMID:Metabolic and endocrine disease and arthritis. 754 15

Enteropathic arthritides, uveitis, and Whipple's disease all belong to the category of spondyloarthropathies. The exact mechanism of relationships among joint, tendon, and axial involvement in the spondyloarthropathies, and gut and eye involvement, is unsolved. Different hypotheses have been proposed to explain the role of enterogenic bacteria in interfering with the HLA system and causing inflammatory reactions in these organs. The microorganism responsible for Whipple's disease (Tropheryma whippelii) has been identified by sequencing the largest part of a bacterial 16S ribosomal RNA, followed by polymerase chain reaction amplification. Late-onset pauciarticular juvenile chronic arthritis should be included in the category of the spondyloarthropathies. New cases of ankylosing spondylitis associated with diffuse idiopathic skeletal hyperostosis have been reported.
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PMID:Enteropathic arthritis, uveitis, Whipple's disease, and miscellaneous spondyloarthropathies. 768 29

Although heterotopic ossification following total hip arthroplasty is frequently observed radiographically, it fortunately is much less commonly of clinical importance. There are, however, a group of patients that develop significant heterotopic bone formation, which can be symptomatic and, in some cases, can require repeat surgery. Careful surgical technique seems indicated in all patients undergoing total hip arthroplasty to try to reduce the incidence of this problem. Patients who are recognized to be at risk should be treated with prophylaxis. These include patients with active ankylosing spondylitis, skeletal hyperostosis, and prior heterotopic bone formation. Both low-dose radiation and nonsteroidal anti-inflammatories have been shown to be effective. The choice between these two modalities depends on the patient's individual circumstances, the availability of radiotherapy support (including custom shielding for ingrowth components), and the presence of areas of bone grafting and any osteotomies or fractures. Nonsteroidal anti-inflammatories, particularly Indomethacin, are a very acceptable form of prophylaxis and may be preferred in certain patients, including young women of childbearing age. Radiation is preferred in those patients with known GI intolerance to these medications or with a prior history of peptic ulcer disease. Excision of heterotopic bone, if symptomatic, should not be performed before 6 to 12 months and then only once it is clear that the process is mature. Bone scans can be helpful in assessing the maturity of heterotopic bone and can guide the timing of excision. Prophylaxis should be carried out in all patients following excision of heterotopic bone.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Heterotopic ossification following total hip arthroplasty. 779 65

Based on a series of eight personal cases and a review of the literature, this study tries to define the diagnostic elements of aseptic osteomyelitis. Although sternocostoclavicular sites are immediately suggestive of the diagnosis, lesions of the pelvis and spine and long bones of the limbs are particularly difficult to diagnose. Inflammatory type pain occurred in episodesover a number of years and responded to NSAIs and possibly diphosphonates. Laboratory abnormalities were usually confined to a raised ESR, but alterations of the IgA levels, similar to those observed in ankylosing spondylitis were observed in four cases. Hyperostosis occurred late in the course, preceded by signs of osteomyelitis, periosteitis or enthesitis. Histology does not provide any formal conclusions. The most suggestive lesions are those of nonspecific aseptic osteomyelitis, followed by a Paget-like appearance. The interpretation of these findings may be complicated by the presence of eosinophils, giant cells or mast cells. Two elements are very valuable for establishing the diagnosis: the presence of infraradiological anterior thoracic increased uptake on bone scan and the presence of a skin disorder, either severe acne or, more especially, palmoplantar pustulosis.
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PMID:[Aseptic osteomyelitis]. 823 70

Intervertebral bony bridging and enthesopathy can occur in both diffuse idiopathic skeletal hyperostosis (DISH) and ankylosing spondylitis (AS) and we have seen difficulties in the radiological differentiation between them. We describe 6 patients selected because the bridges resembled syndesmophytes and this initially suggested a diagnosis of AS, although other considerations showed them to be part of the radiologic picture of DISH. The previously reported suggestions of the coexistence of DISH and AS are reviewed.
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PMID:Radiologic features of DISH may mimic ankylosing spondylitis. 829 51

Eighty-six hips in eighty-five patients who were considered to be at risk for heterotopic ossification following a total hip arthroplasty were prospectively randomized or assigned to one of two treatment groups that received a single 800-centigray dose of limited-field radiation either preoperatively (Group I) or postoperatively (Group II). The risk factors for postoperative heterotopic ossification included previous heterotopic ossification following an operation about the hip, hypertrophic osteoarthrosis or post-traumatic osteoarthrosis characterized by the presence of extensive osteophytes, radiographic evidence of diffuse idiopathic skeletal hyperostosis, and ankylosing spondylitis. The hips in Group I were irradiated within 6.1 hours before the operation and those in Group II, within 51.3 hours after the operation. Either extra-field ossification or heterotopic ossification was observed in forty-one (48 per cent) of the eighty-six hips, thereby confirming the high risk for the population in this study. After a minimum duration of follow-up of six months, thirty-seven (76 per cent) of the forty-nine hips that had been treated with preoperative irradiation exhibited no new heterotopic ossification and eleven, progression to grade-I or II ossification. The remaining hip in that group was in a woman who had Paget disease as well as previous grade-IV (ankylosing) heterotopic ossification about the ipsilateral hip; heterotopic ossification progressed from grade II on the radiographs made immediately after the index revision procedure to grade III at the most recent follow-up assessment. Of the thirty-seven hips that had been treated with postoperative irradiation, twenty-seven (73 per cent) exhibited no new heterotopic ossification and nine had progression from grade-0 to grade-I ossification. The remaining hip in that group was in a man who had Parkinson disease and previous grade-III ossification about the ipsilateral hip; heterotopic ossification progressed from grade III immediately post-operatively to grade IV at the time of the most recent evaluation. Extra-field ossification was identified in twelve (24 per cent) of the forty-nine hips that had been irradiated preoperatively compared with three (8 per cent) of the thirty-seven hips that had been irradiated postoperatively (p = 0.05). Extra-field ossification was not associated with clinical symptoms of bursitis of the greater trochanter in any hip. Three of the ten hips that had a revision operation subsequently had a non-union of the greater trochanter; all three had been treated with preoperative irradiation. The findings of the present study suggest that pre-operative irradiation is effective for the prevention of heterotopic ossification following total hip arthroplasty and that it eliminates the discomfort and morbidity that are associated with conventional postoperative treatment. Furthermore, the efficacy of preoperative irradiation suggests that osteogenic precursor cells that are active in this process are derived from the local tissues within the operative field rather than from distant blood-borne cell lines.
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PMID:Preoperative irradiation for prevention of heterotopic ossification following total hip arthroplasty. 866 5


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