Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01889 (
ankylosing spondylitis
)
5,717
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aortic insufficiency and aortitis are frequent complications of
ankylosing spondylitis
but are considered rare in rheumatoid arthritis. A 49-year-old woman with severe rheumatoid arthritis had the cardiovascular changes common to both diseases. At autopsy, the heart and aorta showed granulomatous ane fibrinous pericarditis and epicarditis, "core" granulomas in the aortic valve cusps and mitral valve leaflets, and coronary arteritis. These are considered to be classical changes of rheumatoid carditis. In addition, there were mesoaortitis with obliterative
endarteritis
of the vasa vasorum and fibrosis of the aortic cusps with separation of the commissures. These are considered to be changes of
ankylosing spondylitis
. This case, therefore, represents a mixed form of cardiovascular involvement within the spectrum of the rheumatoid diseases.
...
PMID:Rheumatoid arthritis with rheumatoid heart disease and granulomatous aortitis. 94 64
