Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Blood T lymphocyte subpopulations were studied by using various monoclonal antibodies in 20 patients with ankylosing spondylitis (AS) and in 20 age and sex matched controls. A significant decrease in OKT4 (p less than 0.04) and OKT8 (p less than 0.02) lymphocytes was demonstrated in AS patients. OKT4 cells were significantly decreased (p less than 0.02) in patients with a severe ankylosis and in those with the longest disease duration. This decrease was not explained by older ages. Thus there was an negative correlation between OKT4 cell ratio and disease duration. No modification in T cell subpopulations was noted when considering HLA B27 positivity or disease activity.
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PMID:[Study of blood T-lymphocyte subpopulations in ankylosing spondylarthritis using monoclonal antibodies]. 623 43

The most common thoracic finding in ankylosing spondylitis (AS) is ankylosis of the costovertebral joints with severe limitation of chest expansion inducing a restrictive syndrome pleural and pulmonary fibrosis can occur during the course of the disease. One-hundred record of patients with AS were reviewed. Five had pleuro-pulmonary involvement. This always included pachypleuritis, usually apical. Roentgenographic pulmonary changes were infiltrates or fibrobullous lesions. Pulmonary function tests showed restriction in four cases, obstruction in one case, and a decreased diffusing capacity in all five cases.
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PMID:[Pulmonary fibrosis in ankylosing spondylitis. Five new cases (author's transl)]. 627 1

Between 1970 and 1979, 17 patients underwent conversion of ankylosed hip to total hip arthroplasty. The patients' ages ranged from 38 to 82 years and the duration of fusion prior to conversion ranged from five to 60 years. The primary indication for conversion to total hip replacement in all patients was disabling pain in the low back, the ipsilateral knee, and the contralateral hip. The reason for ankylosis varied: five patients had previously undergone fusion for posttraumatic arthritis, two patients for tuberculous arthritis, six patients for osteoarthritis, one for a previous old slipped capital femoral epiphysis which had undergone spontaneous fusion after internal fixation, and two patients for ankylosing spondylitis. Relief of preoperative pain in the lower back was seen in 12 of 13 patients, knee pain was relieved in four out of four patients, and contralateral hip pain was relieved in seven out of 10 patients. Complications included heterotopic ossification, infection, perforation of the posterior shaft of the femur, and failure of trochanteric fixation with subsequent dislocation. Predictable pain relief from pain in the contralateral hip was less predictable and directly related to the degree of osteoarthritis in the contralateral hip. In these patients it is suggested that conversion of the fused hip to total hip arthroplasty be staged with total hip replacement in the contralateral hip as well. The end results were least satisfactory in patients with ankylosing spondylitis.
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PMID:Conversion of ankylosed hips to total hip arthroplasty. 645 15

Computed tomography (CT) was used to delineate the paraspinal musculature in 14 patients with ankylosing spondylitis (AS). Abnormal atrophy of the erector spinae muscles and multifidi was demonstrated in all 8 patients with total bony ankylosis of the spine, but was not present in those with isolated syndesmophyte formation, vertebral squaring alone or sacroiliac joint ankylosis with normal spinal radiographs. There was a significant positive correlation between a CT score of paravertebral muscle wasting and clinical parameters of disease duration and restriction of spinal mobility. Wasting and asymmetry of the psoas muscles was seen in 3 patients with unilateral hip joint involvement. These findings suggest that a relationship exists between decreased or absent spinal movement and atrophy of the paraspinal musculature in AS.
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PMID:Computed tomography of paraspinal musculature in ankylosing spondylitis. 652 Aug 34

The relevant literature relating to the etiology and treatment of intra-articular ankylosis of the temporomandibular joint is reviewed, and three cases of ankylosis (one unilateral and two bilateral) are reported. Two of these occurred subsequent to trauma, while the other was a manifestation of severe ankylosing spondylitis. They were successfully treated by interpositional arthroplasty with silicone rubber tubing.
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PMID:Interpositional arthroplasty for ankylosis of the temporomandibular joint. 657 83

Manubriosternal joint abnormalities are often undetected causes of chest pain. Twenty-five normal patients and 40 cadaver specimens were evaluated to establish the normal radiographic anatomy of this articulation. Analysis of the manubriosternal joint was carried out in rheumatoid diseases in order to ascertain the incidence and variety of abnormalities. Twenty-seven of 100 manubriosternal joints were abnormal in rheumatoid arthritis. Of 25 patients with ankylosing spondylitis 20 (80%) revealed abnormalities either with erosions or fusion. None of 25 patients with psoriatic arthritis and none of 20 with Reiter syndrome showed erosions or ankylosis. The articulation should be evaluated in rheumatoid diseases and in non-arthritic patients with chest and/or shoulder pain.
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PMID:The manubriosternal joint in rheumatoid disease. 660 Feb 99

The CT demonstration of gross atrophy of the posterior spinal muscles and the left psoas muscle in a patient with chronic ankylosing spondylitis is reported. The muscle atrophy appeared to be related to gross total ankylosis of the thoracic and lumbar spine and severe unilateral involvement of the left hip joint. This observation suggests a relationship between muscle atrophy, spinal fixation, and reduced joint mobility.
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PMID:Muscle atrophy in ankylosing spondylitis: CT demonstration. 664 55

The enthesopathic lesion of ankylosing spondylitis consists of a nonspecific, nongranulomatous inflammatory lesion which leads to destruction of the attachment of ligament to bone. Resulting erosion leads to reactive bone formation which may form a new enthesis and around the outer fibres of the annulus may lead to syndesmophyte formation. What determines the distribution of the enthesopathy and ankylosis is not known.
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PMID:The enthesopathy of ankylosing spondylitis. 665 94

Information-theoretical considerations demonstrate the uselessness, in terms of understanding and diagnosis, of seven different systems for grading sacroiliitis in ankylosing spondylitis used by German, French, Canadian, Norwegian, Swedish, and Swiss authors. The illustrations prove that it is not possible to differentiate between a normal and abnormal (inflammatory) x-ray of the sacroiliac joints without the application of tomography. A grading system promises diagnostic and communicative success only when based upon tomography results (6 standard sections in adults), and when it takes the "multicolored picture" into consideration ("multicolored picture": no = sacroiliitis stage 0; yes = stage 1; complete bilateral ankylosis: yes = stage 2).
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PMID:[Criticism of sacroiliitis staging in ankylosing spondylitis]. 688 Apr 2

HLA-B27 typing of all arthritic children helped to identify and focus attention on a subset whose disease was pathogenetically related to and demonstrated clinical features of ankylosing spondylitis and Reiter syndrome, but only rarely fulfilled current diagnostic criteria for those disorders (spondyloarthritis). In contrast to other forms of childhood arthritis, enthesopathy (inflammation at the sites of attachment of ligaments and tendons to bone) was a prominent feature in 75%; a family history of similar arthritis was obtained from 60%; boys were more frequently affected (2:1); urethritis, acute iritis, conjunctivitis, or keratoderma blennorrhagicum occurred at some time in 42%; and the initial attack followed an unexplained febrile illness, known dysentery or urethritis, or severe musculoskeletal trauma in 41%. The arthritis was generally pauciarticular, asymmetric, and primarily in the feet and large joints of the lower extremities. Distinctive radiographic features included periostitis, severe osteopenia, calcaneal erosions, and heel spurs; three of 58 had rapid destruction of a single joint. Only ten patients (all boys) were found to have radiographic sacroiliitis after an average of five years of disease, and only three had the Reiter triad. The lifetime risk of sacroiliitis and spinal ankylosis can only be determined by long-term follow-up of such prospectively identified groups of spondyloarthritic children.
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PMID:HLA-B27-associated spondyloarthritis and enthesopathy in childhood: clinical, pathologic, and radiographic observations in 58 patients. 697 33


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