Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01889 (ankylosing spondylitis)
 5,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A number of spinal pathologies result in fusion of the spine, including ankylosing spondylitis, diffuse idiopathic skeletal hyperostosis (DISH), as well as severe degenerative arthropathies. This fusion of spinal elements may result in spinal deformity affecting any region of the spine. Cervicothoracic deformity resulting in chin on chest deformity is poorly tolerated due to inability to maintain a horizontal gaze. Surgical treatment options for this condition are complex and require extensive discussion between the patient and surgical team. Here we present a case report of a 26-year-old transgender female (male to female) patient with severe chin on chest deformity and a unique pattern of spinal fusion involving only the posterior elements. She underwent C2-T8 posterior spinal fusion with thoracic pedicle subtraction osteotomy and multiple cervical facet osteotomies with good functional result. She did have severe dysphagia and required feeding tube for several weeks but did very well by 1 year postoperatively. While posterior elements of the spine are normally affected first in spondyloarthropathies such as ankylosing spondylitis, the lack of anterior spinal involvement is unique and could be attributed to hormonal therapy in this patient. This case describes a unique pattern of spondyloarthropathy and highlights the importance of a having a multi-disciplinary team for the treatment of patients with complex spinal pathologies.
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PMID:Surgical correction of rigid cervicothoracic deformity in a transgender patient: case report. 3310

Osteitis condensans ilii (OCI) is known as one of the sacroiliitis diseases and the symptoms or radiographic findings of OCI sometimes resembled those of ankylosing spondylitis (AS) of non-radiographic axial spondyloarthritis (nr-axSpA). Bone marrow edema (BME) around sacroiliac (SI) joints on MRI is one of the key findings in the classification criteria of axial SpA, but BME on MRI were also found in patients with OCI. The usage of SI joint MRI is increasing due to the needs of accurate or early diagnosis of axial SpA in accordance with development of new biological treatments. Here was the case of a 38-year-old female patient with ulcerative colitis (UC) complicated with OCI, which was a mimic of AS or nr-axSpA. She had a persistent low back pain with BME around SI joints on MRI. She could meet the ASAS criteria of axial SpA and might be diagnosed with inflammatory bowel disease (IBD) related axial SpA. OCI is not a rare disease as a differential diagnosis for axial SpA especially in young women. We report this case with literature review of OCI and would like the clinicians to be aware of the disease when diagnosing AS or nr-axSpA with chronic low back pain.
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PMID:Osteitis condensans ilii in a patient with ulcerative colitis: a mimic of ankylosing spondylitis or non-radiographic axial spondyloarthritis. 3325 9


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