Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors provide the data on the hormonal spectrum (STH, gastrin, sex hormones) in patients with long unhealing duodenal ulcers. It is shown that changes in the concentrations and ratios of the concentrations of hypophyseal-gonadal hormones may serve as a defensive adaptation reaction of the body and may be due to activation of the adaptation systems that mediate the neurohumoral mechanisms of regulation. Such changes are more remarkable in patients with common peptic ulcer. Apparently, in patients with long unhealing ulcers, these mechanisms tend toward depletion, as a result of which the other mechanisms start prevailing (microcirculatory disorders, immunologic abnormalities, pathological microflora).
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PMID:[The role of the hypophyseal-gonadal system in forming long-term nonhealing duodenal ulcers]. 166 96

Plasma levels of gastrin, adrenocorticotropin (ACTH) and somatotropin (STH) were determined 24 hours after pylorus ligation and after pylorus ligation and vagotomy by radioimmunoassay. Pylorus ligation increases the serum levels of these hormones, while vagotomy inhibits the production of these ones. We conclude that the antiulcerogenetic effect of surgical vagotomy is closely related with the changes in the level of these hormones.
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PMID:Gastrin, ACTH and STH after pylorus ligation and vagotomy in rats. 283 73

The effect of a low-dose triphasic oral contraceptive (OC) containing ethinyl estradiol and levonorgestrel (EE/NG) upon thyroid function and some other biochemical serum parameters was compared to that of a preparation containing EE and desogestrel (EE/DG). Blood samples were taken on Day 6, 11, 21, and 28 of a control cycle and of the third cycle of treatment with either the EE/NG or EE/DG preparation (11 volunteers each). After a washout period of 3 months, the contraceptives were changed in a cross-over fashion. Blood samples were again taken on Day 6, 11, 21, and 28 of the third washout cycle and the third treatment cycle. There was a significant increase (13%) in basal glucose level during treatment with both OC, but no change in glucose tolerance. Both the EE/NG and FE/DG preparation elevated serum T4 (40%), FT4 (15-22%), T3 (17-28%), and TBG (20%) significant, whereby the effect was more pronounced during the second treatment period after washing-out. The effective thyroxine ratio (ETR) was slightly (4%) but significantly increased. Contrary to this, the levels of FT3, reverse T3 (rT3), TSH, and gastrin were not altered. STH showed great individual fluctuations, but was significantly elevated by 50% during treatment with both OC. There was no effect of endogenous estradiol upon thyroid or other parameter, even though it was raised considerably in some women under OC. Although the increase in T4 and T3 is probably due to a rise in estrogen-induced TBG production, the data seem to indicate that there is a slight but effective stimulation of thyroid function during treatment with low-dose OC.
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PMID:A randomized cross-over comparison of two low-dose oral contraceptives upon hormonal and metabolic serum parameters: II. Effects upon thyroid function, gastrin, STH, and glucose tolerance. 293 99

The authors gave morphometric assessment of the mucous membrane of the stomach (MMS), investigated the proliferative activity of its cells and the levels of cyclic nucleotides (cAMP and cGMP) in 60 patients with different types of chronic gastritis. A parallel study was made of the blood levels of cortisol, thyroxine, insulin, STH, and gastrin. 10 healthy persons were investigated for control. A decrease in MMS thickness, redistribution of the sizable lobes of the glandular epithelium and stroma in favor of the latter were shown in atrophic (but not superficial) gastritis. In patients with atrophic gastritis the proliferative activity of MMS cells was significantly raised, the blood levels of cortisol and gastrin were elevated, the level of thyroxine was lowered, and insulin and STH levels were normal. Marked MMS atrophy was accompanied by cAMP and cGMP insufficiency. The relationships between the morphofunctional status and the proliferative activity of MMS cells, on the one hand, and the activity of the hormonal-cyclase systems, on the other hand, were followed. The mechanisms of pathological regeneration of MMS cell elements was specified, and its importance in the morphogenesis of atrophic gastritis was confirmed.
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PMID:[Hormonal mechanisms of morphofunctional changes in the gastric mucosa in chronic gastritis]. 336 57

Blood levels of STH, ACTH, somatostatin, bombesin, gastrin, hydrocortisone, aldosterone, testosterone, estradiol, progesterone and gastric juice levels of gastrin and somatostatin were measured in remission and exacerbation of gastric and duodenal ulcer (GU), (DU) using radioimmunoassay. The study included 250 DU, 200 GU and 5O control subjects. As a result, two forms of DU were identified. DU type 1 is characterized by basal and stimulated hypergastrinemia, paradoxical D-cell response to stimulation, high blood concentrations of STH, ACTH, testosterone. Type 2 DU exhibits basal hypogastrinemia, elevated gastrin concentration in response to stimulation, adequate reaction of D-cells, low levels of estradiol and progesterone. In GU there were low concentrations of STH, bombesin, hydrocortisone, estradiol, testosterone, progesterone, somatostatin. D-cell response to loading was adequate. It is concluded that DU and GU pathogeneses are different, that DU is a heterogeneous disease.
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PMID:[The hormonal characteristics of the pathogenesis of gastric peptic ulcer and duodenal peptic ulcer]. 877 96

The role of gastrin, STH, insulin and glucose in the formation, and long-term adaptation of gastric secretion in athletes--wrestlers in the sportive and post sportive ontogeny Revealed an undulation in the age dynamics of the basal secretion of hormones and glucose in the blood. The ups and downs of different waves in the dynamics occur in sensitive periods of ontogeny. In a bicycle stress load changes in the secretion of hormones and glucose levels in 90% of cases are not statistically significant, but insufficient to achieve the end result of regulation--an adequate level of hydrolysis of proteins in response to physical stress.
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PMID:[Participation of growth hormone and insulin in the regulation of gastric secretion in athletes wrestler in sportive and post sportive ontogenesis]. 2080 58