Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01350 (
gastrin
)
9,683
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Our previous studies demonstrated that expression and interaction of p16 with
anion exchanger 1
(
AE1
) in gastric cancer cells is correlated with progression and shorter survival of the cancer. In this article, the effects of
gastrin
on p16 and
AE1
and its implication in prevention and treatment of gastric cancer were studied by molecular biology techniques, animal experiment and clinical analysis. The results showed that expression of p16 in human gastric body carcinoma was downregulated along with the progression of the cancer, suggesting the reverse correlations between
gastrin
and p16 in vivo. Further experiments indicated that
gastrin
suppressed the expression of p16 via the p16 promoter and thereafter resulted in the degradation of
AE1
in gastric cancer cells. Silencing of
AE1
or p16 significantly inhibited the proliferation of the cancer cells. Using a xenograft tumor model in nude mice, we showed that experimental systemic hypergastrinemia induced by the administration of omeprazole led to decreased expression of
AE1
and p16 as well as to a marked growth inhibition of SGC7901 tumors. It is concluded that a moderate plasma
gastrin
level is beneficial to the growth inhibition of gastric cancer by suppressing the expression of
AE1
and p16. This finding may have an important implication for the prevention and treatment of cancers arise in the gastric antrum.
...
PMID:Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells. 2002 Apr 91
