Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-five patients with fulminant hepatic failure and grade III or IV hepatic encephalopathy were studied. Plasma insulin, glucagon, pancreatic polypeptide and enteroglucagon were significantly raised. Levels of secretin and gastrin were normal, while motilin concentrations were significantly depressed. Vasoactive intestinal polypeptide was increased in six patients and was significantly higher in those patients who were hypotensive or who had marked prolongation of prothrombin time.
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PMID:The gut hormone profile of fulminant hepatic failure. 732 45

This study aims to investigate the gastrointestinal functions of patients with liver failure (LF) based on gastrointestinal dysfunction (GD) scores and serum gastrointestinal hormone levels.The GD in LF patients was scored using the gastrointestinal dysfunction scoring criteria. Serum gastrin (GAS), cholecystokinin (CCK), and motilin (MTL) levels were determined in LF patients. In addition, liver function and prothrombin activity were detected, and ultrasonography was performed.The GD score was significantly higher in the LF groups than in the control group. Compared with the control group, serum GAS, CCK, and MTL levels significantly increased in the LF groups, and was positively correlated with the severity of LF. Furthermore, in the LF groups, GD was positively correlated with the severity of LF. However, the GD score and serum GAS, CCK, and MTL levels in the acute LF group were not statistically different, when compared with those in the subacute LF group, acute-on-chronic LF group and chronic LF group.LF plays a key role in the development of GD, and may be the main cause of obvious gastrointestinal symptoms, such as abdominal distension, nausea, vomiting and anorexia, in LF patients. The severity of GD is not associated with LF type, but is positively correlated with the severity of LF, suggesting that GD in LF patients may have complicated mechanisms.
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PMID:STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure. 3050 96