Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The concentrations of gastrin were measured by the RIA method in the sera of 121 healthy Greek volunteers of both sexes and of different ABO blood groups, aged 20--70 years. The determinations took place in a fasting state in all the individuals and 10 min and 40 min after a test meal in 42 of them. No significant differences were found in the mean concentrations of gastrin in the fasting state and after the meal between the various ABO groups. There was an increase in the mean concentrations of gastrin in all the groups after the meal. Nevertheless, this was significant 40 min after the meal in the groups A and B whilst in the group O and in the groups A, B and AB considered together this significant increase had appeared already 10 min after the meal.
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PMID:Serum gastrin concentrations in healthy people of the various ABO blood groups. 72 18

Serum pepsinogen 1, serum gastrin, ABO blood groups, secretor status of ABH blood group substances and behavioral factors were studied in 15 patients with duodenal ulcer and 61 their relatives affected and unaffected to duodenal ulcer. Duodenal ulcer patients had hyperpepsinogenemia 1 either with or without a positive family history of duodenal ulcer. Serum gastrin level was higher in duodenal ulcer patients and unaffected relatives with a positive family history of duodenal ulcer than those with a negative family history. Non secretor status was frequently observed in duodenal ulcer patients with a positive family history. There was no difference in behavioral factors between duodenal ulcer patients and unaffected relatives with a positive family history. It is concluded that genetically determined variables such as hyperpepsinogenemia 1 and non secretor status play an important role on the susceptibility to duodenal ulcer in subjects with a positive family history, and hypergastrinemia may be subclinical marker of familial aggregation of duodenal ulcer.
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PMID:Serum pepsinogen 1, gastrin, ABO blood groups, secretor status of ABH substances and behavioral factors in patients with duodenal ulcer and their relatives. 319 59

A series of duodenal ulcer patients was studied to determine the relationship of the integrated postprandial gastrin response with the maximal acid secretory capacity, the ABO blood groups, age of onset of ulcer dyspepsia, and the family history of ulcer dyspepsia of the patients. It was found that: 1. The A, B, AB duodenal ulcer patients had a significantly higher maximal acid gastric secretory capacity (P less than 0.001), significantly earlier age of onset of ulcer dyspepsia (P less than 0.001) and significantly stronger family history of dyspepsia (P less than 0.05) than those patients with O blood group. 2. The integrated gastrin response was significantly higher in "hipersecreting" duodenal ulcer patients (secreted more than 25 mMol/h in response to histamine) than in "normosecreting" duodenal ulcer patients (secreted less than 25 mMol/h) (P less than 0.001) but the values for the latter were not different from normal subjects. 3. There was not statistical significant difference between the mean values of the basal serum gastrim levels of normosecreting duodenal ulcer patients, the hypersecreting duodenal ulcer patients and the normal subjects. 4. A significant positive correlation exists between the maximal acid output and integrated postprandial gastrin response in duodenal ulcer patients. (P less than 0.001). This correlation was negative in the normal subjects (P less than 0.01). 5. This finding supports the existence of a positive relationship between the functioning parietal cell and gastrin cell masses.
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PMID:[Types of duodenal ulcer according to antrum function: its relation to the gastric acid secretory capacity and blood group. Therapeutic implication]. 713 52