Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01350 (
gastrin
)
9,683
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Connective tissue growth factor
(
CTGF
) has been reported in gastric adenocarcinoma and in carcinoid tumors. The aim of this study was to explore a possible link between
CTGF
and
gastrin
in gastric epithelial cells and to study the role of
CTGF
in
gastrin
induced migration and invasion of AGS-GR cells. The effects of
gastrin
were studied using RT-qPCR, Western blot and assays for migration and invasion. We report an association between serum
gastrin
concentrations and
CTGF
abundancy in the gastric corpus mucosa of hypergastrinemic subjects and mice. We found a higher expression of
CTGF
in gastric mucosa tissue adjacent to tumor compared to normal control tissue. We showed that
gastrin
induced expression of
CTGF
in gastric epithelial AGS-GR cells via MEK, PKC and PKB/AKT pathways.
CTGF
inhibited
gastrin
induced migration and invasion of AGS-GR cells. We conclude that
CTGF
expression is stimulated by
gastrin
and involved in remodeling of the gastric epithelium.
...
PMID:Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion. 2717 76
