Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten cases of cerebellar haemangioblastoma were studied using the immunoperoxidase technique for glial fibrillary acidic protein (GFAP), Factor VIII-related antigen (F8RA), Ulex europeus agglutinin 1 (UEA-1), S-100 protein, neurone-specific enolase (NSE), leucocyte common antigen, synaptophysin, chromogranin and eight polypeptide hormones (bombesin, pancreatic polypeptide, somatostatin, thyroglobulin, calcitonin, glucagon, insulin and gastrin). GFAP and S-100 were demonstrated at the periphery of all tumours and in small groups of cells in the centre of four cases. Most of these cells had the morphology of reactive astrocytes but some had the appearance of stromal cells. In general stromal cells gave negative results. F8RA and UEA-1 stained the endothelial cells in each case but there was no stromal cell reactivity. NSE was present in the stromal cell component of all tumours. There was no staining for synaptophysin, for chromogranin, or any of the polypeptide hormones. It therefore appears that some haemangioblastomas contain an admixed non-neoplastic astrocytic element. NSE, F8RA and UEA-1 staining demonstrates that the endothelial and stromal cell parts of the tumour are antigenically distinct. Recent reports of polypeptide hormone expression cannot be confirmed and it is therefore unlikely that stromal cells originate from primitive peptidergic neurones.
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PMID:Haemangioblastoma. An immunohistochemical study of ten cases. 339 96

31 cases of the so-called sclerosing hemangiomas of the lung were studied by light microscope, immunohistochemical and electron microscopy. This tumor is benign and has 3 histologic patterns: papillary, hemangioma-like and solid type. Characteristic morphology being uniform round tumor cells, lying within the stroma in different patterns and regarded as the major component of sclerosing hemangioma, expressing neuroendocrine markers which include chromagranin A, neuron-specific enolase, ACTH, growth hormone, calcitonin and gastrin. Only a few tumor cells were positive for epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA), all the tumor cells were negative for keratin (Polyclonal, Z622) stain. However, in contrast to the round tumor cells, the cells lining papillary projections or cystic spaces, which presented as normal or hyperplastic alveolar cells, stained positive for keratin, EMA and CEA but negative for neuroendocrine markers. Both the surface cells and tumor cells were negative for Factor VIII-related antigen and alpha 1-AT. Therefore, pulmonary sclerosing hemangioma was regarded to be a benign tumor originating from the neuroendocrine cells of the lung and we suggest that it be renamed as benign neuroendocrine tumor of the lung (LBNET). This viewpoint has not been previously reported in the literature.
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PMID:[A benign neuroendocrine tumor of the lung: study on the origin of the so-called sclerosing hemangioma of the lung]. 808 41

Malignant mesenchymal neoplasms of the pancreas are rare and malignant islet cell tumors with sarcomatous dedifferentiation are rarer still. We present a case of malignant islet cell tumor with sarcomatous differentiation, which to our knowledge is only the second reported case showing such a combination of morphologic features. Clinically, the neoplasm was not hormonally active and immunohistochemical staining was negative for gastrin, glucagon, insulin and somatostatin. The sarcomatous component strongly reacted with an antibody directed against vimentin, and a minority of cells stained strongly with antisera directed against desmin and smooth muscle actin. The spindle cell component was nonreactive with antibodies directed against Factor VIII. The myogenous direction of differentiation in the present tumor is similar to that seen in the prior case report of malignant islet cell tumor with rhabdomyosarcomatous differentiation.
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PMID:Malignant islet cell tumor with sarcomatous differentiation. 1170 83