Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To elucidate the ectopic hormonal pattern in patients with small cell carcinoma of the lung, plasma ACTH, serum calcitonin, serum gastrin, plasma glucagon, serum insulin, plasma secretin, plasma VIP, serum growth hormone, serum hCG/LH, the total of serum hCG and hCG-beta-subunit,serum alpha-subunit, serum human placental lactogen, urine ADH, urine 5-HIAA, urine VMA, urine HVA, and urine hCG-LH were measured prior to therapy in 75 patients. Twenty-two patients (29%) had elevated plasma ACTH, and 18 of these had concomitant increased values of corticosteroid in a 24-hour urine sample. Forty-eight patients (64%) were found to have elevated serum calcitonin, and one-third of the patients were diagnosed as having the ectopic ADH syndrome. Serum gastrin concentrations were increased in 20% of the patients, but the elevations were marginal in almost all cases. None of the remaining substances was found to be significantly elevated. Concentrations of plasma ACTH, serum calcitonin, and urine ADH were not found to be correlated with the stage of the disease, and no correlation of these substances with the histological subtypes of small cell carcinoma was disclosed.
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PMID:Hormonal polypeptides and amine metabolites in small cell carcinoma of the lung, with special reference to stage and subtypes. 624 82

The case of a patient with small-cell carcinoma of the lung, bone marrow metastases, and hypertrophic pulmonary osteoarthropathy is reported. Normal growth hormone serum concentrations contrasted with significant increases in ACTH, beta-MSH, calcitonin, and gastrin. A hormonal etiology has previously been suggested for hypertrophic pulmonary osteoarthropathy. Our findings indicate that the hormone responsible for hypertrophic pulmonary osteoarthropathy may be an APUD polypeptidic substance, that differs from immunoreactive GH but is related to somatomammotropins.
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PMID:[Hypertrophic pulmonary osteoarthropathy with paraneoplastic secretion of four hormones. Considerations on pathogenesis (author's transl)]. 627 40

Using immunoperoxidase techniques, the possible localization of pituitary regulatory peptides in fundic, antral and duodenal mucosae was investigated in both rat and man. All results obtained were similar in the two species. No glycopeptide (FSH, LH, TSH) was detected in the digestive tract. With different antisera directed against beta-lipotropin, alpha-MSH, beta-MSH, endorphins, ACTH 1-24, ACTH 17-39, a positive reaction was only obtained in the antral mucosae with an antiserum specific for the synthetic fragment 17-39 of ACTH. However neither the common precursor, proopiomelanocortin, nor the complete sequence of ACTH seem to be present in endocrine cells of the digestive tract. On the other hand, three antisera, directed against human growth hormone (GH), visualized numerous endocrine cells scattered in the glandular epithelium of the fundic and antral mucosae. Most cells were identified as ECL type in the gastric mucosae. Others are probably of the gastrin cell type in the antral mucosa, since these cells could be visualized on adjacent sections either with the antiserum against GH, or with a specific antiserum for gastrin.
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PMID:[Cytologic demonstration of immunoreactivity characteristic of adenopituitary peptides in the digestive epithelium of the rat and man]. 632 84

The levels of growth hormone, vasopressin, prolactin, calcitonin, gastrin, insulin, epinephrine, norepinephrine and dopamine were measured in six lactating women during breast feeding. Prolactin levels increased in response to suckling as expected. In addition, insulin levels rose two-fold. No consistent changes were observed in the levels of the other hormones. It is suggested that the suckling related insulin release is either secondary to a reflexly induced activation of the vagal nerves or to the increased circulating levels of prolactin. Furthermore, it is suggested that the insulin release in response to suckling participates in the stimulation of milk production.
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PMID:Suckling in lactating women stimulates the secretion of insulin and prolactin without concomitant effects on gastrin, growth hormone, calcitonin, vasopressin or catecholamines. 638 80

Somatostatin and gastrin-like immunoreactivity was measured in peripheral venous plasma at 22, 24, 02, 04 and 06 hours in 10 experiments performed on 6 healthy volunteers. In five of the experiments the subjects had been pretreated with propranolol 20-40 mg three times daily for one week. At 22 h gastrin and somatostatin levels averaged 153 and 143 pg/ml without treatment with beta-blockers and 93 and 74 with such treatment. Gastrin and somatostatin levels fell during the course of the night to approximately 10 and 60% of the 22 h value, respectively. Somatostatin levels reached their lowest value at 02 h (50%) of the 22 h value. Treatment with beta-blockers tended to decrease gastrin as well as somatostatin levels over the whole experimental period, but did not influence the gradual decline of gastrin and somatostatin levels occurring during the night or the 02 h dip in somatostatin levels. It is suggested that the nocturnal dip in somatostatin secretion is vagally mediated and that the peak in acid output occurring at this hour is due to the decreased output of gastric somatostatin. The fact that the nightly dip in somatostatin secretion coincides with the peak output of the pituitary hormones prolactin and growth hormone is discussed.
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PMID:Nocturnal variation in plasma levels of gastrin and somatostatin-like immunoreactivity in man. 654 20

The role of endogenous opioid peptides in mediating the endocrine and metabolic response to pelvic surgery was investigated. Fourteen patients were studied; seven were infused with the specific opioid antagonist, naloxone, at a rate of 20 micrograms kg-1 (body weight) hr-1, while the remainder acted as a control group. Naloxone exacerbated the glycaemic response to surgery but had no statistically significant effect on changes in the glycoregulatory hormones, pancreatic glucagon, insulin, cortisol and growth hormone. However, there was a wide individual variation in the glucagon response to naloxone with marked stimulation in some patients. Naloxone infusion increased plasma pancreatic polypeptide secretion during the 1st hour of surgery and reversed the decline in plasma motilin concentrations, but had no effect on circulating somatostatin, vasoactive intestinal polypeptide, gastrin, enteroglucagon and neurotensin values. We conclude that endogenous opioid peptides have only a limited role in modulating the endocrine and metabolic response to surgery.
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PMID:The effects of naloxone on circulating metabolites, glycoregulatory hormones and gut peptides during pelvic surgery. 668 26

The effect of human growth hormone (hGH) on gastrin secretion was evaluated in 13 hyposomatotropic children and two subjects with bioinactive growth hormone (GH). Serum concentrations of gastrin were quantitated by radioimmunoassay after ingestion of a standard meal and following intravenous infusion of arginine, prior to and after 6 and 12 months of hGH administration. Although the meal provoked a significant increment in gastrin values at each point, hGH did not alter basal concentrations or or meal-evoked secretion of gastrin in these subjects. Arginine had no effect on gastrin levels. Serum immunoreactive insulin concentrations increased in response to eating and arginine, but hGH did not alter the insulin secretory response to either stimulus. It is concluded that hGH did not affect the secretion of gastrin or insulin under the conditions of this study.
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PMID:Effect of human growth hormone on gastrin secretion in children with hyposomatotropism. 676 9

Ultrastructural investigation of 274 human pituitary adenomas and 39 nontumorous adenohypophyses revealed two distinct types of secretion. Exocytosis was characteristic of prolactin cell adenomas, mixed growth hormone-prolactin cell adenomas, acidophil stem cell adenomas, and nontumorous prolactin cells. The second type, termed "transmembrane effusion," was noted in corticotroph, thyrotroph, gonadotroph, undifferentiated cell adenomas, and oncocytomas, as well as nontumorous corticotrophs, thyrotrophs, and gonadotrophs. It differed from that of prolactin cells and resembled diacrine secretion of gastrointestinal gastrin cells and membrane release in the neurohypophysis. In adenomatous and nontumorous growth hormone cells, neither exocytosis nor transmembrane effusion were apparent, hence a third type of release is suggested. Electron microscopic study of release mechanisms is helpful in the differential diagnosis of pituitary adenomas, since discharge of secretory products is not identical in the various tumor types.
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PMID:Fine structural features of secretion in adenomas of human pituitary gland. 677 93

The effect of porcine gastrin releasing peptide (GRP), a heptacosapeptide with potent gastrin releasing activity which has recently been isolated from porcine non-antral gastric tissue, on pituitary function was investigated in the rat. Graded doses of synthetic porcine GRP were injected intravenously and the animals were killed at various intervals after injection. Prolactin, growth hormone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) were measured in serum by specific radioimmunoassays. GRP had no significant effect on prolactin, growth hormone or FSH serum concentrations at any dose or sampling time studied. In contrast, the heptacosapeptide significantly stimulated LH release and suppressed TSH secretion with injection of low doses. There are striking structural and some functional similarities between GRP and bombesin, an amphibian skin tetradecapeptide which shows amino acid homology with the C-terminal region of GRP. This suggests that the endocrine effects of GRP may be mediated by its bombesin-like residue.
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PMID:Gastrin releasing peptide: endocrine functions in the rat. 685 57

Recent studies indicate that calcitonin inhibits, in man, the secretion of several hormones such as gastrin, insulin, growth hormone. There are no reports about this effect in uremic patients in which frequently calcitonin, gastrin, growth hormone, and insulin response to glucose administration is increased. A comparative study of the effects of synthetic salmon calcitonin infusion (50 U iv) on gastrin, growth hormone and insulin release protein meal (250 g of boiled lean beef) in 10 uremic patients undergoing hemodialysis and in 10 normal subjects was performed. Insulin and growth hormone response to protein meal was inhibited by calcitonin both in normal and uremic subjects. Gastrin response instead was inhibited only in normal subjects. These findings indicate that in uremic patients the inhibitory effect of calcitonin on insulin and growth hormone secretion is still present. The lack of evident inhibitory effect on gastrin release could be related to persistent hypergastrinemia because of the increased half life of the hormone which could mask acute changes of secretion.
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PMID:Effects of synthetic salmon calcitonin administration on gastrin, immunoreactive insulin and growth hormone release after protein meal in uremic patients. 702 92


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