Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For the first time, the distribution of N-cadherin and neural cell adhesion molecule (NCAM) as well as some neuropeptides in nerve cells and endocrine cells of the human embryonic and fetal gastroenteropancreatic system has been detected in early stages (from the 6th postovulatory week onwards). Epithelial cells of the stomach and small intestine contained gastrin and somatostatin and the epithelium of the small intestine also bombesin-positive cells. Myenteric ganglionic cells showed both bombesin and VIP and were NCAM- and N-cadherin-positive at all ages studied. Some basally granulated epithelial cells of stomach, duodenum and the upper part of jejunum contained N-cadherin. The number of these cells increased from 6th to 10th postovulatory weeks. Nerve cells and the cytoplasm of individual epithelial cells of pancreatic ducts were immunoreactive for NCAM and N-cadherin. NCAM- and N-cadherin-positive cells also appeared in Langerhans islets (> 10 weeks), mainly in their peripheral part. NCAM- and N-cadherin-positive endocrine cells were less numerous than endocrine cells producing somatostatin, bombesin, and VIP, probably reflecting the features of embryonic/fetal histogenesis of Langerhans islets from epithelial endocrine cells of pancreatic ducts. NCAM and N-cadherin were localized on the surface of endocrine islets cells as well as in the cytoplasm of single islet cells. This suggests the involvement of both membrane and soluble forms of adhesion proteins in embryonic/fetal histogenesis of human pancreatic islets. The early occurrence of N-cadherin (6th postovulatory week) in enteroendocrine cells supports the existence of a common precursor. The expression of NCAM and N-cadherin in nerve cells and endocrine cells of the human fetal gastroenteropancreatic system may indicate the involvement of neuronal adhesion mechanisms in the development of neuro-endocrine complexes of fetal stomach, small intestine and pancreas.
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PMID:Distribution of N-cadherin and NCAM in neurons and endocrine cells of the human embryonic and fetal gastroenteropancreatic system. 954 83

We previously reported that Reg IV is associated with neuroendocrine (NE) differentiation in gastric cancers. The aim was to examine which NE hormone products are related to Reg IV-positive NE cells and their roles in gastric cancers. In the present study, we performed immunohistochemical analysis in a tissue microarray (TMA) of a consecutive series of 630 cases with ten different antibodies, including chromogranin A, synaptophysin and neural cell adhesion molecule (NCAM) as NE differentiation markers, and gastrin, serotonin, calcitonin, gastrin-releasing peptide (GRP), pancreatic polypeptide (PP), somatostatin and glucagon as NE hormones. In 630 cases, we identified 205 (33%) with NE differentiation and 147 (23%) positive for Reg IV. Reg IV-positive cases showed NE differentiation more frequently than Reg IV-negative cases (P < 0.0001). In 205 cases with NE differentiation, Reg IV-positive cases expressed serotonin (P= 0.0032) and somatostatin (P= 0.036) more frequently than Reg IV-negative cases. Double immunofluorescence staining revealed co-expression of Reg IV with gastrin, serotonin and PP. These results indicate that Reg IV might be a mediating factor of several NE hormones.
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PMID:Immunostaining of gastric cancer with neuroendocrine differentiation: Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, pancreatic polypeptide and somatostatin. 2040 31