Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was designed to measure plasma gastrin and somatostatin levels in infants and to simultaneously investigate the infants' metabolic status as reflected by the body weight as well as by the blood levels of FFA, D-beta-hydroxybutyrate and glucose. Healthy infants (n = 94) who were born at term were studied cross-sectionally during their first four days of life. We found that the gastrin concentration (mean +/- SD) on the first day of life was 118 +/- 37 pmol/l. Subsequently the concentration decreased and reached its lowest value on the third day; 94 +/- 27 pmol/l (P less than 0.05). On the fourth day the mean concentration increased to the same level as on the first day. There was a significant (P less than 0.01) increase in somatostatin concentrations from 18 +/- 6 pmol/l on the first day to 26 +/- 7 pmol/l on the fourth day and the concentrations were highly related (P less than 0.0001) to postnatal age. We conclude that the decrease in gastrin concentration is probably related to the low volume of breast milk ingested during the first days after delivery, and therefore to the low secretory activity of the gastrin-producing cells. The infants' catabolic condition during that time was evidenced by the reduction in body weight, the decrease in plasma glucose level and the increase in FFA and D-beta-hydroxybutyrate levels. The gastrin increase found on the fourth day reflects most likely, the change in breast milk availability which occurs with the establishment of lactation. The mechanisms controlling the release of somatostatin remains to be established.
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PMID:Plasma gastrin and somatostatin levels in infants during the first four postnatal days. 198 40

Malnutrition may cause to the damage intestinal epithelium and pancreas resulting in overt signs of malabsorption syndrome. The diet protein, fats and carbohydrates stimulate secretion, CCK-P, GIP, and gastrin release and effect insulin and HGH release. The amounts of the hormones released depends on intestinal absorption and pancreas secretory function. Therefore, in undernourished children with malabsorption syndrome on impaired function of the hormonal entero-insular axis is likely. In 30 children hormonal component of malnutrition was studied. Digestion and absorption were assayed by glycemic levels and FFA, with hydroxyprolinuria studies following administration of the mixed test meal. HGH and IRI levels were measured following mixed test meal stimulation. Hormonal studies data were correlated with digestion and absorption indices. In undernourished children low levels of HGH and IRI were frequently found. In certain patients with malnutrition the administration of anabolic drugs seems to be advisable.
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PMID:[Food stimulated release of IRI and HGH in children with malabsorption (author's transl)]. 610 40