Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01350 (
gastrin
)
9,683
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report a search in cold, quiescent and in 'hot core' type interstellar molecular clouds for the small cyclic molecule oxiranecarbonitrile (
C3H3NO
), which has been suggested as a precursor of important prebiotic molecules. We have determined upper limits to the column density and fractional abundance for the observed sources and find that, typically, the fractional abundance by number relative to molecular hydrogen of
C3H3NO
is less than a few times 10(-10). This limit is one to two orders of magnitude less than the measured abundance of such similarly complex species as CH3CH2CN and HCOOCH3 in well-studied hot cores. A number of astrochemical discoveries were made, including the first detection of the species CH3CH2CN in the massive star-forming clouds
G34
.3+0.2 and W51M and the first astronomical detections of some eight rotational transitions of CH3CH2CN, CH3CCH, and HCOOCH3. In addition, we found 8 emission lines in the 89 GHz region and 18 in the 102 GHz region which we were unable to assign.
...
PMID:A search for interstellar oxiranecarbonitrile (C3H3NO). 1153 52
We report on using the synthetic aminoadamantane-CH
2
-aryl derivatives
1
-
6
as sensitive probes for blocking M2 S31N and influenza A virus (IAV) M2 wild-type (WT) channels as well as virus replication in cell culture. The binding kinetics measured using electrophysiology (EP) for M2 S31N channel are very dependent on the length between the adamantane moiety and the first ring of the aryl headgroup realized in
2
and
3
and the girth and length of the adamantane adduct realized in
4
and
5
. Study of
1
-
6
shows that, according to molecular dynamics (MD) simulations and molecular mechanics Poisson-Boltzmann surface area (MM/PBSA) calculations, all bind in the M2 S31N channel with the adamantyl group positioned between V27 and
G34
and the aryl group projecting out of the channel with the phenyl (or
isoxazole
in
6
) embedded in the V27 cluster. In this outward binding configuration, an elongation of the ligand by only one methylene in rimantadine
2
or using diamantane or triamantane instead of adamantane in
4
and
5
, respectively, causes incomplete entry and facilitates exit, abolishing effective block compared to the amantadine derivatives
1
and
6
. In the active M2 S31N blockers
1
and
6
, the phenyl and isoxazolyl head groups achieve a deeper binding position and high
k
on
/low
k
off
and high
k
on
/high
k
off
rate constants, compared to inactive
2
-
5
, which have much lower
k
on
and higher
k
off
. Compounds
1
-
5
block the M2 WT channel by binding in the longer area from V27-H37, in the inward orientation, with high
k
on
and low
k
off
rate constants. Infection of cell cultures by influenza virus containing M2 WT or M2 S31N is inhibited by
1
-
5
or
1
-
4
and
6
, respectively. While
1
and
6
block infection through the M2 block mechanism in the S31N variant,
2
-
4
may block M2 S31N virus replication in cell culture through the lysosomotropic effect, just as chloroquine is thought to inhibit SARS-CoV-2 infection.
...
PMID:Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels. 3278 58
