Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01350 (
gastrin
)
9,683
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gastrin
/CCK(B) G protein-coupled receptors have been shown to mediate proliferation stimulated by their endogenous ligands. The present study demonstrates the proliferative effect of arachidonic acid on AR4-2J cells.
Gastrin
induces an [3H]arachidonic-acid release in a dose-dependent manner. The use of a specific inhibitor of
cPLA2
, AACOCF3 established the involvement of a
cPLA2
in the proliferative effect of
gastrin
. The results also demonstrate that a cytosolic high-molecular-weight PLA2 is activated by
gastrin
in AR4-2J cells.
...
PMID:Arachidonic-acid-selective cytosolic phospholipase A2 is involved in gastrin-induced AR4-2J-cell proliferation. 946 14
