Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum gastrin increased in patients with pernicious anaemia after a beef-meal, but decreased after an oral load of glucose, xylose or sodium chloride. 50 g of glucose and 25 or 75 g of xylose suppressed serum gastrin to approximately 40% of basal values at 60 min and were slightly more effective than 10 g of sodium chloride. There was no rise in beef-meal stimulated serum gastrin concentration in vagotomized patients and only a slight rise in two patients with duodenal ulcer when an oral dose of 10 g of sodium chloride was given together with the beef-meal. 25 g of xylose suppressed basal serum gastrin concentration significantly in six vagotomized patients. Nasal administration of small amounts of vasopressin decreased basal serum gastrin significantly in six vagotomized patients. Nasal administration of small amounts of vasopressin decreased basal serum gastrin significantly in all subjects examined. Further studies indicated, however, that vasopressin was only effective when pharmacological plasma concenten orally and intraduodenally were compared in six patients with pernicious anaemia. Serum gastrin concentration decreased approximately to the same extent in both experiments. It is concluded that the inhibitory effect of glucose on gastrin secretion most likely is mediated hormonally via osmo-receptors located in the small intestine.
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PMID:Inhibition of gastrin secretion by hypertonic solutions in patients with pernicious anaemia and duodenal ulcer. 11 45

The authors report here the results of prospective clinic study on 108 cases of the early stage of Gan-Zheng (infantile malnutrition) in children. It was proved that professor Zhan Qisun's tested recipe Sheng-Zhang-Ling(SZL) had an obvious effect in treating children with early stage of Gan-Zheng. The total effective rate was 90.2%, and the significantly effective rate was 60.79%. Various symptoms of patients using this prescription disappeared or improved. The increase of body weight, height and subcutaneous fat of these patients was faster than those of the blank control group and the group using zinc sulfate. The difference was statistically significant among those three groups. It was indicated that effects of the SZL group were not caused by children's natural growth and development. There was an obvious advantage over the zinc sulfate group with regard to clinical effects, side effects and total synthetic effects. It was concluded SZL is an effective prescription for curing patients with early stage of Gan-Zheng and stimulating children's growth and development. Hemoglobin, D-xylose in urine, serum gastrin, serum zinc ion were detected before and after the treatment. It was suggested that SZL had the effects to stimulate gastrointestinal secretion and absorption, to improve digestive function, to increase serum zinc ion and to cure anemia.
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PMID:[Early stage of gan-zheng in children treated with sheng-zhang-Ling]. 239 42

Eleven adult Basenji dogs with immunoproliferative small intestinal disease (IPSID) were studied. Two items of history related to the digestive tract were characteristic: (i) chronic intractable diarrhea in most dogs, and (ii) progressive emaciation. Anorexia was intermittent in only a few dogs. In addition, skin lesions of various degrees of severity were observed, including alopecia of pinnae and ventrum, hyperpigmentation and hyperkeratosis of pinnae, and necrosis and ulcerations of margins of pinnae. The cause of the skin lesions was not determined; however, hypothyroidism did not appear to contribute to the skin changes. Standard hematologic and serum chemical values were not consistently abnormal. However, a poorly regenerative anemia, mild neutrophilia, and increased aspartate aminotransferase and alanine aminotransferase activities were generally observed in severely affected dogs. The Pelger-Huet anomaly was identified in dog 3. Maldigestion and malabsorption as determined by the N-benzoyl-L-tyrosyl-p-aminobenzoic acid and d-xylose test was documented to varying degrees in dogs with IPSID. Maldigestion was correlated with functional pancreatic exocrine insufficiency. Severe malabsorption was documented in only 3 dogs. Serum gastrin values were evaluated in these dogs because of a prior observation of parietal cell hyperplasia and gastric ulceration. Hypergastrinemia was documented in 3 dogs. Additional studies will be necessary to determine whether an acid hypersecretory state contributes to the pathogenesis of IPSID in Basenjis.
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PMID:Clinical and laboratory characterization of Basenjis with immunoproliferative small intestinal disease. 660 87