Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fasting and postprandial gastroesophageal sphincter pressure (GESP) and plasma gastrin immunoreactivity were measured in 6 dogs from 9 through 60 months after treatment for and recovery from gastric dilatation-volvulus (GDV). The GESP was not significantly increased in these dogs, compared with that in clinically normal dogs in either the fasting or postprandial state. Corresponding plasma gastrin immunoreactivity was not significantly increased in dogs of the GDV-recovered group, compared with that in clinically normal dogs (fasting or postprandial). An exaggerated increase in GESP in response to food-induced gastrin release was not observed in dogs of the GDV-recovered group. Exogenously administered pentagastrin (3-micrograms/kg bolus, IV) increased fasting GESP in clinically normal dogs over a 4-minute test period (P = 0.01). Gastric distention in response to oral administration of isosmolar saline solution (500 ml) did not significantly increase GESP or plasma gastrin immunoreactivity in clinically normal dogs. In anesthetized clinically normal dogs, gastric distention in response to use of balloons filled to exert intragastric pressure of 30 mm of Hg also did not cause significant increase in plasma gastrin immunoreactivity. Increased GESP, secondary to hypergastrinemia or gastric distention, is an unlikely cause of eructation failure in dogs with GDV.
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PMID:Relationship of plasma gastrin immunoreactivity and gastroesophageal sphincter pressure in clinically normal dogs and in dogs with previous gastric dilatation-volvulus. 278 5

It has been thought that upper intestinal symptoms of heartburn, regurgitation, belching, and chest pain experienced during exercise may represent esophageal dysfunction. The aim of this study is to examine esophageal function during moderate exercise in asymptomatic healthy athletes. Six healthy male athletes were exercised for 2 h on a treadmill set at a workload of 50% of their maximum oxygen uptake. Esophageal motility studies were performed immediately before, immediately after, and 1 h after the exercise. The mean lower esophageal sphincter pressure increased from a base line of 24 to 32 mm Hg immediately postexercise (p less than .01), reducing to 27 mm Hg after 1 hour rest. The mean amplitude and duration of esophageal peristalsis remained unchanged throughout the study. The significance of the lower esophageal sphincter pressure increase with moderate exercise is unknown but may relate to the observed exercise-induced increase in serum motilin, gastrin, and catecholamines.
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PMID:Effect of moderate exercise on esophageal function in asymptomatic athletes. 377 51

The authors report their experience with a case of double duodenum carcinoid tumors occurring in a 59-year-old female patient. She presented with a one-year history of frequent abdominal painful episodes, associated with dyspepsia, emesis, pyrosis, eructation, skin flushing and easy strain. The laboratory examinations point out high hematic values of serotonin and gastrin, with a raising of urinary 5-HIAA. Preoperative endoscopic examinations showed the presence of 2 little sessile polypoid growths, placed in the duodenal bulb, one of this interested muscular tunic. The patient underwent Billroth I resection and was discharged on postoperative day 8. The authors after a little dissertation on that topic, go on to examine the current diagnostic and therapeutic possibilities. They confirm the elective role of surgical treatment of these rare tumors.
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PMID:[Neuroendocrine tumors. A rare case of duodenal carcinoids]. 1699 60

In this article we reported a female patient with type 1 gastric neuroendocrine tumor (NET). Gastroscopy showed the presence of multiple polyp-like lesions sized 0.2-1.5 cm in the fundus and body of stomach. The main clinical manifestations were belching and fullness after a meal. She had a history of autoimmune atrophic gastritis and laboratory tests showed increased serum gastrin and acid deficiency, which met the diagnostic criteria of type 1 gastric NET. Treatments included endoscopic resection, sandostatin, and traditional Chinese herbs, and no relapse was noted during follow-up visits. The patient also had rectal NET. By analyzing this case, we tried to explore the diagnostic algorithm and clinical typing of type 1 gastric NET; meanwhile, along with literature review, we described the relapse rate of this disease and the value of regular follow-up (every 6-12 months). Finally, we analyzed the value of somatostatin analogue (SSA) in treating multiple type 1 gastric NET and in this case we demonstrated that SSA was effective in dissolving NET.
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PMID:Gastric neuroendocrine tumor (NET): report of one case. 2813 50