Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In sheep as in other species, intracerebroventricular (ICV) administration of picomolar doses of several peptide hormones affects food intake and rumination, suggesting that these hormones play a role in the physiological control of feeding behavior. Their effects depend on their duration (short vs long-term) and/or their nature (orexigenic vs anorexigenic). Among the short-term satiety factors, CCK8, CRF and calcitonin, administered ICV, decrease food intake by reducing the rate (CCK8) or the duration (CRF, calcitonin) of ingestion; in contrast, the gastrin group of peptides (gastrin 17, penta or tetragastrin) reduces food intake by promoting an early period of rumination. Opioid peptides such as Met-enkephalin and Dynorphin initiate food intake in satiated sheep and are supposed to be active in the short-term regulation of food intake in these ruminants. In contrast both calcitonin gene-related peptide (CGRP) and growth hormone-releasing factor (GRF) increase the daily food intake, when ICV injected, but their centrally mediated orexigenic effects depend on the regimen and the digestive status. These results confirm the species differences observed in food intake regulation and the major role of the C.N.S. in controlling feeding behavior and energy balance in ruminants.
 ...
PMID:[Control of ingestive behavior and rumination by neuropeptides]. 310 14

Effects of intracerebroventricular (ICV) vs. intravenous (IV) administration of tetragastrin, pentagastrin, CCK8 and gastrin 17 on rumination were investigated in conscious sheep. Administered at 26 pmoles/kg ICV both tetra and pentagastrin induced a premature short (15-27 min) period of rumination only 24 +/- 7 and 23 +/- 9 min after food distribution in place of 112 +/- 44 min in controls. Similar but less pronounced effects were observed for ICV administration of an equimolar dose of gastrin 17 whereas CCK8 did not promote an early period of rumination despite its anorectic effects. Administered intravenously tetra and pentagastrin but not gastrin 17 caused early rumination only for 10 times higher doses. It is concluded that gastrin 17 and its C-terminal tetrapeptide may play a physiological role in the central control of rumination in sheep.
 ...
PMID:Evidence for central neuropeptidergic control of rumination in sheep. 632 51