Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

50 adult Wistar male rats were used and divided into 4 groups, i.e. normal control group, experimental Spleen Deficiency group induced by rhubarb, spontaneous recovery group and therapeutic group treated with Chinese recipe (Si Jun Zi decoction). All the animals of the 4 groups were killed simultaneously, and the jejunum and ileum were removed and processed for demonstration of gastrin cells and 5-HT cells according to immunohistochemical PAP technique. In addition, HE stained samples were prepared. The immunoreactivities of the two types of enteroendocrine cells were observed and semiquantitative estimation were performed under light microscopy. In addition, the immunoreactivities of 5-HT cells in normal control and experimental Spleen Deficiency group were measured by microspectrocytophotometer (MPV 2, Leitz). All the data were treated statistically. This study revealed that there were no obvious histological changes in the mucosa among the 4 groups. In the jejunum, the percentage of gastrin cells(+) in experimental Spleen Deficiency group was more than that of the normal control group, while the percentage of gastrin cells( ) was less than that of the normal control group. As compared with spontaneous recovery group, it showed contrary to the above result in the therapeutic group. No gastrin cells were found in the ileum in all the 4 groups. the percentage of 5-HT cells did not show significant changes in the jejunum and ileum among the 4 groups. But immuno-reactivity in the 5-HT cell was less than that of the normal control group in the jejunum of the Spleen Deficiency group.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Immunohistochemical study on the enteroendocrine cells of the small intestine in experimental spleen deficiency syndrome in rats]. 147 6

Observations on gastric acid secretion, plasma gastrin and prostaglandin E1 in patients with peptic ulcer disease were made after giving acupuncture with Na Ja Fa. The relationship between the chosen points and their effects was also discussed so as to provide more evidence to evaluate and practice the traditional chronoacupuncture more accurately. The results of this experiment were: (1) The gastric acid output of patients with peptic ulcer disease was decreased, while the plasma gastrin and prostaglandin E1 were increased after puncturing with Na Ja Fa. This reveals that the decrease of acid output was not caused by the change of plasma gastrin, however the plasma prostaglandin E1 may be involved in this process. (2) By using points on Stomach and Spleen meridians, there was a better inhibiting effect in acid output than treating the points of other meridians. This showed that using chronoacupuncture should include choosing points according to differentiation and only by laying stress on the relative specialization of the actions of these points one could expect improvement in efficiency. (3) There were no obvious differences between the standard opening points and the group of points which changed to opening points by Dr Shan Yu Tang. This proves that these two groups of points do have some similar functions and are both effective for clinical use.
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PMID:[Effects of chronoacupuncture na ja fa on gastric acid secretion, plasma gastrin and prostaglandin E1 in patients with peptic ulcer]. 206 57

161 cases of chronic gastritis (including 59 superficial gastritis, 86 atrophic gastritis, 16 superficial gastritis combined with atrophic gastritis) typed in deficiency syndrome (including 64 Spleen-deficiency syndrome, 97 Spleen-Kidney-deficiency syndrome) were studied clinically with modern medicinal multiple-index. The gastroscope image, pathologic changes of gastric mucosa, stomach barium meal examination, gastric acid, serum gastrin, urine pepsinogen, urine 17-ketosteroid, vegetative nerve function, peripheral blood picture, etc. were selected as observation indices. The preliminary findings showed that in Spleen-deficiency patients, the superficial gastritis constituted the majority, the asthenic stomach constituted the minority, the gastric secretion and the serum gastrin were on the high side, the urine pepsinogen, the adrenocortical function and the hemoglobin were on the low side, but the white blood cell was rather normal; otherwise, in Spleen-Kidney deficiency patients, the atrophic gastritis and the asthenic stomach constituted the majority, the gastric secretion decreased, the serum gastrin level was higher, while the urine pepsinogen, the adrenocortical function, white blood cell and the hemoglobin were on the low side. It was also found that in certain same inflammation changes, the gastric secretion of the Spleen-Kidney-deficiency syndrome was markedly than that of Spleen-deficiency syndrome. With the treatment method of invigorating the Spleen and reinforcing the Spleen-Kidney, each index was relatively improved. The degree of seriousness to inflammation changes of gastric mucosa and the disturbance or imbalance of gastric secretion function were reflected from the Spleen-deficiency and the Spleen-Kidney-deficiency syndromes of chronic gastritis. It is suggested that hemopoiesis and hypothalamo-adenohypophysial-adrenal cortical axis be influenced.
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PMID:[Deficiency syndrome of chronic gastritis]. 220 29

According to "Spleen-Stomach" theory, the effect of Jianpi Yiqi prescription (JPYQ) was observed clinically and studied experimentally. 168 cases manifested as Spleen-Qi ( ) deficiency including chronic gastritis and peptic ulcer (84 cases), chronic glomerulonephritis (44 cases) and vomitus gravidarum-edema of pregnancy (40 cases) were treated with JPYQ. Estimation were made based on their clinical conditions. Serum gastrin, serum cholyglycine, blood acetylcholine and cholinesterase, blood 5-HT and histamine were measured before and after treatment. The overall effective rate was 92.9% in gastritis and peptic ulcer group, 86.3% in nephritis group and 100% in pregnancy group respectively. A marked increase of serum glycocholic acid level was shown in gastritis and peptic ulcer and vomitus gravidarum groups. That was considered as the result of the secretion of cholic acid by this prescription. Clinical improvement was also obtained in nephritis group accompanying disappearance of albuminuria in 36.4%. Blood level of 5-HT and histamine lowered to some extent and tended to be normal. Besides, this prescription markedly inhibited electric stimulated excitement on isolated longitudinal muscle strip of guinea pig's ileum. The mechanism could be the inhibition of release of acetylcholine from Auerbach's plexus by this prescription.
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PMID:[Clinical and experimental study on the prescription of jianpi yipi]. 259 59

In this paper, 89 Spleen deficiency (SD) patients' gastric mucosa specimens obtained during fibrogastroscopy mucosal biopsy were observed with immunocytochemical-stereologic-quantitative analysis method. The number of G cells counted and the content of basic gastrin in serum measured. This study found that the difference of the number of G cells and the content of gastrin in serum possessed statistical significance between two types of SD. The results suggested the hyperplasia and hypersecretion of G cells in gastric antrum might be an important pathological mechanism for different types of SD.
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PMID:[The stereologic-quantitative analysis of gastric antrum G cells in patients with splenic diseases]. 262 81

In this study, Syndrome of Deficiency revealed that gastric acid secretion, cellular immunity, hematopoietic and synthetic metabolism were all decreased. The RBC, Hb, TG, HDL-C, CD8, infection rate of HP, the degree of atypical hyperplasia and the staining intensity of PNA were different for Spleen-Kidney-Deficiency syndrome from spleen-Deficiency syndrome, the former was lower than the latter, while LPO was higher and ESR was faster for the former. Syndrome of Excess revealed that the serum gastrin level was higher, humoral immunity and catabolic metabolism were increased, its blood was in hyperviscosity and hypercoagulation state. The Qi Stagnation with Blood Stasis was different from the Qi stagnation alone which including the atrophic degree of the former was severer, the ESR was faster than that of the later. The Heat Stagnation (HS), retention of Dampness (RD) and Damp-Heat (DH) have some difference. First, for secretion of gastric acid. HS was the lowest, DH the next, RD the third. Second, for the level of LPO, HS was the highest.
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PMID:[Deficiency and excess syndrome of chronic atrophic gastritis]. 831 96