Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01350 (gastrin)
 9,683 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Coffee as a rule develops stimulating effects on the central nervous system, heart and circulation which are mainly caused by caffeine. In certain cases coffee may also have a sedative effect and sometimes even it is useful to fall asleep quickly. Furthermore coffee may be advantageous in the treatment of some functional disorders caused by lacking of dopamine, because coffee is able to increase the dopamine formation in brain. Concerning the effects of coffee in the gastrointestinal-tract and liver-bile system caffeine is only of secondary importance. Hereby certain roasting substances, possibly also chlorogenic acid or caffeic acid should be responsible for the stimulating effects observed in these organs. These stimulating effects could be caused whether directly or indirect e.g. by liberating gastrin or other gastrointestinal hormones. Vitamin niacin, which is formed in greater amounts from trigonelline during the roasting process, may also be important from the nutritional standpoint. Therefore coffee may be prescribed as a true drug in cases of deficiency in vitamin niacin or also in the pellagra disease. By extensive epidemiological studies performed lately it could be demonstrated that there exists no correlation between coffee consumption and certain risk factors as hypertension, heart infarction, diabetes, gout or cancer diseases. Furthermore there was no evidence that coffee or its caffeine content are able to induce genetic alterations or even malformations.
 ...
PMID:[Coffee and health]. 60 27

The aims of this study were to determine the prognosis for women with different symptoms and signs indicating ischaemic heart disease and to relate entry characteristics to events of ischaemic heart disease and stroke, and to overall mortality during a 12-year follow-up period. A prospective cohort study was started as a cross-sectional investigation in 1968-69 (1462 participants aged 38-60, participation rate 90.1%). The same sample was re-studied in 1980-81 (1154 participants, participation rate 78.9% of those studied in 1968-69). In addition, a clinical series comprising all women of similar age in Gothenburg with myocardial infarction during the years 1968-70 (47 women) was followed up for 12 years. The 12-year overall mortality rate for women with initial myocardial infarction in the clinical series was 45%. The 12-year overall mortality rates for women who at the time of the initial study either were considered to have angina pectoris or showed electrocardiographic changes indicating ischaemic heart disease at rest or at work were 10%, 17% and 10% respectively (expected figures 7%, 12% and 10%). Twenty-three women (1.6%) developed myocardial infarction during the follow-up period (8 fatal, 15 non-fatal). New symptoms of angina pectoris were recorded in 56 women (4.0%), new electrocardiographic changes indicating ischaemic heart disease in 73 women (6.0%), and new signs of stroke in 13 women (0.9%). Altogether 75 women (5.1%) died during the follow-up period. These five end-points were taken into consideration. Women with previously untreated arterial hypertension were offered control visits during the follow-up period and were prescribed antihypertensive drugs when clinically indicated. In this group of women, hypertension was not a predictor for any of the end-points. No other systematic intervention was carried out. Increased abdominal adiposity, increased serum triglycerides and low peak expiratory flow were independent predictors of at least three of the end-points studied: myocardial infarction, stroke and death. Increased abdominal adiposity was also an independent predictor of angina pectoris. Initial diabetes was an independent predictor of both myocardial infarction and of death. Low energy intake predicted myocardial infarction and electrocardiographic changes indicating ischaemic heart disease. High serum gastrin levels predicted myocardial infarction. Low education and high degree of mental disorder were independent predictors of angina pectoris. Physical inactivity at leisure and physical inactivity at work were independent predictors of stroke and of death, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:Ischaemic heart disease, stroke and total mortality in women--results from a prospective population study in Gothenburg, Sweden. 387 72

We determined gastrin and pepsinogen I in serum samples obtained in 1968-69 from 256 women (175 women 54 years old and 81 women 60 years old when sampled). The concentration of gastrin in serum was significantly (p less than 0.01) and positively correlated with the incidence of myocardial infarction during a 12-year follow-up, with age taken into account as a background variable in multivariate analysis. It was not correlated with overall mortality or with the 12-year incidences of angina pectoris, electrocardiographic changes indicating ischemic heart disease, or stroke. The correlation with myocardial infarction was independent of smoking, systolic blood pressure, indices of obesity, concentrations of blood glucose during fasting and of serum triglycerides and cholesterol, and of the presence of diabetes mellitus at screening or during follow-up. Serum gastrin was significantly (p less than 0.05) related to body mass index (positive age-specific relation) and to smoking (negative age-specific relation). These findings may provide a new aspect to analysis of risk factors for myocardial infarction.
 ...
PMID:Hypergastrinemia--a risk factor for myocardial infarction? 397 91

Extrapituitary roles for hypothalamic neurohormones have recently become apparent and clinically relevant, based on the use of synthetic peptide analogs for the treatment of multiple conditions including cancers, pulmonary edema and myocardial infarction. In the eye, it has been suggested that some of these hormones and their receptors may be present in the ciliary body, iris, trabecular meshwork and retina, but their physiological role has yet to be elucidated. Our study intends to comprehensively demonstrate the expression of some hypothalamic neuroendocrine hormones and their receptors within different retinal and extraretinal structures of the human eye. Immunofluorescence, Western blot analysis, and RT-PCR were used to evaluate the qualitative and quantitative expression of Luteinizing Hormone Releasing Hormone (LHRH), Growth Hormone Releasing Hormone (GHRH), Thyrotropin Releasing Hormone (TRH), Gastrin Releasing Peptide (GRP) and Somatostatin as well as their respective receptors (LHRH-R, GHRH-R, TRH-R, GRP-R, SST-R1) in cadaveric human eye tissue and in paraffinized human eye tissue sections. The hypothalamic hormones LHRH, GHRH, TRH, GRP and Somatostatin and their respective receptors (LHRH-R, GHRH-R, TRH-R, GRPR/BB2 and SST-R1), were expressed in the conjunctiva, cornea, trabecular meshwork, ciliary body, lens, retina, and optic nerve.
 ...
PMID:Expression of hypothalamic neurohormones and their receptors in the human eye. 2897 97