Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P01275 (glucagon)
 26,492 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
glucagon 26492
insulin 15833
somatostatin 3261
Sep 1740
gut 1665
GLP-1 receptor 1605
growth hormone 1394
pancreatic polypeptide 1227
GLP-1 1202
peptidase 1023
AMP 1002
gastrin 912
secretin 900
Mol 845
adenylate cyclase 800
cholecystokinin 765
polypeptide 648
glucose-dependent insulinotropic polypeptide 619
DPP 586
ATP 570
ghrelin 551
leptin 534
glucagon receptor 513
peptide YY 498
vasopressin 472
calcitonin 419
hemoglobin 390
amylin 344
vasoactive intestinal peptide 338
gastric inhibitory polypeptide 329
GLP 328
dipeptidyl peptidase IV 323
ACTH 319
beta-endorphin 306
neurotensin 306
albumin 291
prolactin 270
proinsulin 262
phosphoenolpyruvate carboxykinase 244
GIP 237
substance P 236
phosphodiesterase 235
vasoactive intestinal peptide (VIP) 228
adenylyl cyclase 223
amylase 221
SRIF 221
CCK 214
bombesin 211
glucokinase 205
VIP 204
parathyroid hormone 199
GTP 194
neuropeptide Y 182
insulin receptor 180
pituitary adenylate cyclase-activating polypeptide 180
Gen 180
epidermal growth factor 176
angiotensin II 171
endoplasmic reticulum 167
pyruvate kinase 165
motilin 165
cytokine 163
collagenase 159
glycogen phosphorylase 157
glucose transporter 156
GHRH 154
oxytocin 151
chromogranin A 140
INS-1 140
adiponectin 138
G protein-coupled receptor 136
ADP 134
renin 133
collagen 131
glucose-6-phosphatase 130
PKA 129
PDX-1 126
casein 123
tumor necrosis factor 120
serum albumin 120
glycogen synthase 120
IGF-I 114
phosphatase 113
insulin-like growth factor 112
caspase-3 109
Net 107
GIP receptor 102
AMP-activated protein kinase 102
cAMP-dependent protein kinase 101
peroxidase 101
Ghrelin 100
lipopolysaccharide 100
Growth hormone 98
sodium-glucose cotransporter 95
ATPase 95
NIDDM 94
mTOR 94
lipase 93
TNF 93
GLP-2 receptor 93
microsomal 89
IDDM 89
thyroid hormone 85
calmodulin 85
CD26 85
Leptin 82
galanin 81
glycoprotein 80
adrenocorticotropic hormone 80
homeobox 79
GLUT2 79
CREB 79
TAT 79
neuron-specific enolase 79
interleukin-6 79
NMR 78
threonine 78
DPP IV 78
synaptophysin 78
ERK1 77
peroxisome proliferator-activated receptor 77
IL-6 77
CO2 76
PI3K 75
NEFA 75
AMPK 74
alkaline phosphatase 74
SDS 73
calcium channel 73
insulin-like growth factor-I 71
tyrosine hydroxylase 71
gastrin-releasing peptide 71
arginine vasopressin 71
HDL 70
STZ 69
epididymal 68
membrane-bound 67
PHI 67
Met 67
STC-1 67
AKT 66
5-hydroxytryptamine 66
PTH 65
GABA 65
nitric oxide synthase 64
IGF-1 63
NAD 63
GLP1 62
TGR5 62
insulin-like growth factor I 62
Pol 61
glucosidase 61
PC1/3 60
pyruvate carboxylase 60
protein kinase B 60
Bcl-2 60
G-protein-coupled receptor 58
MAPK 58
lipoprotein lipase 58
GLI 58
more...
Disease
diabetes 5794
type 2 diabetes 3025
hypoglycemia 2325
hyperglycemia 1822
obesity 1417
tumor 741
hyperinsulinemia 640
glucose intolerance 623
type 1 diabetes 618
cancer 332
insulinoma 316
SEM 257
cardiovascular disease 257
glucagonoma 255
cirrhosis 221
hypertension 212
Alzheimer's disease 203
metabolic syndrome 191
depression 181
fatty liver 176
heart failure 164
pancreatitis 155
stroke 148
cold 146
pertussis 146
Pancreas 144
Pancreas 140
hepatocellular carcinoma 140
ischemia 132
carcinoma 128
ketosis 125
chronic pancreatitis 122
hyperlipidemia 118
metastases 112
cholera 112
short bowel syndrome 108
myocardial infarction 106
atherosclerosis 103
sepsis 102
sepsis 100
diabetic ketoacidosis 100
acute pancreatitis 99
dyslipidemia 98
hyperphagia 96
liver disease 93
renal disease 90
carcinoid 85
multiple endocrine neoplasia 83
Parkinson's disease 81
malnutrition 76
SDS 73
chronic renal failure 72
malabsorption 67
anemia 65
acromegaly 63
adenocarcinoma 62
alcoholic fatty liver 60
diabetic nephropathy 59
renal failure 58
pheochromocytoma 58
SMS 56
neuropathy 56
cognitive impairment 55
Pituitary 55
pancreatic cancer 54
hypothyroidism 53
INS 53
celiac disease 53
uremia 52
portal hypertension 51
autonomic neuropathy 51
prediabetes 51
coma 50
hyperthyroidism 48
osteoporosis 48
metabolic disorder 47
retinopathy 46
gestational diabetes mellitus 45
GSH 45
adenoma 44
plaque 44
coronary artery disease 40
diabetic retinopathy 40
glycogen storage disease 40
rash 40
fits 39
liver metastases 39
cystic fibrosis 39
NAME 39
Best 39
tumor growth 38
myocardial ischemia 38
Zollinger-Ellison syndrome 37
Nonalcoholic fatty liver 37
inflammatory bowel disease 36
gastrinoma 36
medullary thyroid carcinoma 35
colitis 34
renal impairment 33
neuroendocrine tumor 33
dehydration 33
hepatitis 33
Evans 32
Crohn's disease 32
hyperparathyroidism 32
Cushing's syndrome 32
Klebsiella 31
diabetic hyperglycemia 31
NOD 31
carcinogenesis 31
growth hormone deficiency 31
essential hypertension 30
GAD 30
chronic disease 30
chronic liver disease 30
dementia 30
hypopituitarism 29
lactic acidosis 29
vascular disease 28
cholestasis 28
CTX 27
encephalopathy 27
asthma 27
dermatitis 27
hypercholesterolemia 27
morbid obesity 26
duodenal ulcer 26
neuroblastoma 26
coronary heart disease 25
hypercalcemia 25
heart disease 25
Brown 24
cerebral ischemia 24
gallstones 24
congestive heart failure 24
tumorigenesis 24
renal insufficiency 23
acute myocardial infarction 22
polycystic ovary syndrome 22
Necrolytic migratory erythema 21
Blocking 21
TEM 20
hepatic encephalopathy 20
TEM 20
NPH 20
dumping syndrome 20
pancreatic insufficiency 20
steatorrhea 20
primary hyperparathyroidism 20
islet cell carcinoma 19
wasting 19
anorexia nervosa 19
iron overload 19
schizophrenia 19
autoimmune disease 19
neuroendocrine carcinoma 19
ulcerative colitis 18
somatostatinoma 18
diabetic cardiomyopathy 18
thyrotoxicosis 18
more...
Symptom
starvation 273
hunger 175
overweight 172
anesthesia 150
nausea 143
diarrhea 135
anorexia 99
erythema 93
vomiting 85
pain 75
exhaustion 61
seizures 59
fatigue 45
hypothermia 34
ketonuria 34
cachexia 33
nausea and vomiting 32
hepatomegaly 30
discomfort 30
discomfort 30
weakness 28
abdominal pain 28
headache 24
polyuria 22
constipation 22
spasm 21
polydipsia 20
analgesia 19
collapse 19
acute stress 18
Ill 15
angina 14
lethargy 14
colic 14
tremor 13
flushing 12
decreased appetite 10
dizziness 10
functional recovery 10
hypotonia 10
bitter taste 8
respiratory distress 7
pallor 7
hypercapnia 6
epigastric pain 6
agitation 6
emaciation 6
hypoproteinemia 6
bone pain 5
HSA 5
acidity 5
ataxia 5
sleepiness 5
memory loss 5
dyspnea 4
ENT 4
acute pain 3
microbial colonization 3
asthenia 3
vertigo 3
splenomegaly 3
cyanosis 3
hyperoxia 3
syncope 3
autodigestion 3
regurgitation 3
blurred vision 3
tonic-clonic seizure 3
stomach distension 3
thinning 3
myalgia 2
wheezing 2
thirsty 2
bloating 2
Gastrointestinal symptoms 2
cough 2
rhinorrhea 2
enuresis 2
paresis 2
urinary frequency 2
paresthesia 2
tingling 2
sore throat 2
low back pain 2
heartburn 2
generalized rash 2
dry eye 2
skin irritation 2
adipsia 2
eds 2
back pain 1
breath holding 1
twitching 1
Early satiety 1
Macula 1
hot flashes 1
night sweats 1
distraction 1
skin damage 1
hot flushes 1
incoordination 1
eye pain 1
chills 1
Tenderness 1
Tissue sensitivity 1
Appetite suppression 1
abdominal discomfort 1
Catch 1
numbness 1
Neuropathic pain 1
catarrh 1
chest pain 1
abdominal cramps 1
Welt 1
labored breathing 1
cardialgia 1
chorea 1
sneezing 1
stomach pain 1
oliguria 1
physical appearance 1
rigors 1
No adverse effect 1
Depressive symptoms 1
hepatosplenomegaly 1
hip pain 1
muscle rigidity 1
right lower quadrant pain 1
ophthalmoplegia 1
loss of taste 1
motor symptom 1
cancer pain 1
body pain 1
dystonia 1
dysuria 1
KIDNEY 1
cardiovascular problem 1
otalgia 1
anosmia 1
Poor weight gain 1
arthralgia 1
abdominal fullness 1
exertional angina 1
retching 1
tachypnea 1
Stepping 1
fasciculation 1
dry skin 1
Respiratory symptoms 1
Mills 1
muscle stiffness 1
excessive sweating 1
Wind 1
insomnia 1
periorbital edema 1
Nasal inflammation 1
bewilderment 1
loss of equilibrium 1
prostration 1
frequent urination 1
more...
Drug
Glucagon 3742
Liraglutide 243
Exenatide 157
lysine 139
Secretin 117
Gel 103
Cardiovasc 92
Nephron 89
Growth hormone 88
Growth hormone 87
Portal 80
PTH 67
caffeine 54
NADH 53
Asn 52
Alanine 51
Forskolin 43
GRF 40
lactose 39
Phentolamine 34
Fructose 34
Atropine 33
Ethanol 31
Dermatol 31
Theophylline 31
CTX 29
Pramlintide 29
CPR 29
Angiotensin II 28
Teduglutide 26
CTX 26
CTX 26
Glycerol 24
ROS 22
Sandostatin 22
Sandostatin 22
Bifidobacterium 21
nitroglycerin 19
Albumin 18
ascorbate 17
IL-2 16
CaCl2 15
ENT 15
ADM 15
ICI 15
Activin 15
Histamine 14
Clonidine 14
GHRP 14
CaCl2 14
CaCl2 14
MAP 14
CSF 14
vitamin E 14
NH3 14
citric acid 13
Aprotinin 13
Nephron 13
Monit 12
Scopolamine 12
Ouabain 12
Diurnal 11
HCG 11
Buscopan 11
Humulin 11
IFN-gamma 10
Glutathione 10
DMI 10
TAT 9
NVP 9
DNase I 9
Januvia 9
Dial 9
Rosiglitazone 9
Leaf 8
Galactose 8
ROC 8
EPI 8
Indomethacin 8
EE2 7
Amiloride 7
p75 7
Amiloride 7
Orlistat 6
HCH 6
Biopolymers 6
MRC 6
pyridoxal phosphate 6
Paraffin 6
Gliclazide 6
Troglitazone 6
Glide 6
ampicillin 6
Ringer's solution 6
EPA 5
RFP 5
Clofibrate 5
Trifluoperazine 4
Adenosine deaminase 4
Rolipram 4
Serum albumin 4
Liposyn 4
Bevacizumab 4
L-tyrosine 4
PCB 4
Estrogens 4
Dextrose 4
ABC 4
Insulin detemir 4
AHF 4
Pro-Banthine 4
Hypaque 4
Methylene blue 4
Salbutamol 4
NAG 4
Heme 4
Vitamin B 4
Lactose 4
Fraction 4
Taxol 3
Isotretinoin 3
Omeprazole 3
Imatinib 3
Sandostatin LAR 3
Symlin 3
Thiopentone 3
-deoxyadenosine 3
CIA 3
OctreoScan 3
Pitressin 3
metformin hydrochloride 3
Amrinone 3
Digitalis 3
FAD 3
Vitamin E 3
Hypaque 3
Retinoic acid 3
Colesevelam 3
Rimonabant 3
CAM 3
Parkin 3
CoCl2 3
Apomorphine 3
ZnCl2 3
Voglibose 3
CoCl2 3
Insulin glargine 3
DM1 3
Prednisone 3
ETA 3
Ximelagatran 3
Papain 3
Parkin 3
ZnCl2 3
TRM 3
9-THC 3
Kenyan 3
Ranitidine 3
balanced salt solution 3
Artemether 2
more...
Enzyme
adenylate cyclase 854
protein kinase 702
phosphorylase 325
phosphoenolpyruvate carboxykinase 259
dipeptidyl peptidase IV 245
phosphodiesterase 240
phosphoenolpyruvate carboxykinase 239
phosphoenolpyruvate carboxykinase 236
mitogen-activated protein kinase 205
glucokinase 205
protein kinase C 193
AMPK 174
AMP-activated protein kinase 172
pyruvate kinase 165
collagenase 158
trypsin 139
renin 133
peroxidase 132
glucose-6-phosphatase 131
ATPase 105
lipase 103
ERK 98
caspase-3 86
alpha-glucosidase 82
phospholipase C 79
tyrosine aminotransferase 79
alkaline phosphatase 76
AMPK 75
tyrosine hydroxylase 70
catalase 68
alanine aminotransferase 63
pyruvate carboxylase 62
superoxide dismutase 61
lipoprotein lipase 60
phosphofructokinase 58
acetyl-CoA carboxylase 57
calcineurin 56
phosphorylase kinase 55
luciferase 53
lactate dehydrogenase 52
phosphatidylinositol 3-kinase 52
CPT 52
glucose-6-phosphate dehydrogenase 46
focal adhesion kinase 45
CD10 43
MEK 42
ornithine decarboxylase 41
aspartate aminotransferase 40
hexokinase 38
furin 37
chymotrypsin 37
CPR 36
reverse transcriptase 34
glutathione peroxidase 34
adenosine deaminase 33
adenosine deaminase 33
pyruvate dehydrogenase 32
alcohol dehydrogenase 30
sucrase 30
insulin-degrading enzyme 30
NO synthase 30
GSK 28
invertase 28
hormone-sensitive lipase 27
creatine kinase 27
fructose 1,6-bisphosphatase 27
ACS 26
pyruvate dehydrogenase 26
pyruvate dehydrogenase 26
guanylate cyclase 26
CPT 25
6-phosphofructo-2-kinase 25
elastase 25
phosphoinositide 3-kinase 24
RNase 24
RNase 24
chloramphenicol acetyltransferase 24
ACE 22
phospholipase A2 22
CPT 22
lysozyme 21
tryptophan 2,3-dioxygenase 21
beta-lactamase 21
CaMKII 20
5'-nucleotidase 19
NADPH oxidase 19
glutamate dehydrogenase 18
glutamate dehydrogenase 18
gamma-glutamyl transpeptidase 18
pepsin 18
glutamate dehydrogenase 18
acid phosphatase 18
thrombin 17
glucose oxidase 17
acetylcholinesterase 16
PDE 16
enolase 16
ADH 16
glutaminase 16
phenylalanine hydroxylase 16
beta-galactosidase 15
cathepsin B 15
NADPH oxidase 15
PAL 15
alpha-amylase 15
ribonuclease 15
glutamate decarboxylase 15
succinate dehydrogenase 15
ribonuclease 15
argininosuccinate synthetase 14
proteasome 14
arginase 14
glutathione S-transferase 14
lactase 14
citrate synthase 14
choline acetyltransferase 13
CPS 13
cathepsin D 13
RNA polymerase 13
subtilisin 12
PAL 12
lipoxygenase 12
phospholipase D 12
AGT 12
aldolase 12
MDP 12
kallikrein 11
thymidine kinase 11
NOS 11
SPT 11
complex I 11
carboxypeptidase E 11
aldehyde dehydrogenase 11
PDK1 10
malate dehydrogenase 10
3-hydroxy-3-methylglutaryl-CoA reductase 10
hyaluronidase 10
acyl-CoA oxidase 10
glutamine synthetase 10
PKG 10
SST 10
carboxypeptidase B 10
carboxypeptidase A 10
cholinesterase 9
AMP-activated kinase 9
CYP7A1 9
AST 9
hyaluronidase 9
proprotein convertase 1 9
caspase-1 9
TAT 9
enterokinase 9
glyceraldehyde-3-phosphate dehydrogenase 9
glutathione-insulin transhydrogenase 8
3-hydroxy-3-methylglutaryl coenzyme A reductase 8
glyceraldehyde-3-phosphate dehydrogenase 8
DNase 8
alpha-ketoglutarate dehydrogenase 8
diaphorase 8
heme oxygenase 8
more...
Compound
glucose 12790
Glucagon 3742
Clin 2009
Dec 1851
Insulin 1835
cAMP 1591
arginine 1308
calcium 1249
AMP 1090
sodium 861
alanine 710
water 628
Pac 605
DPP 586
ATP 570
DNA 543
glycerol 533
oxygen 502
Diabetol 407
leucine 402
phosphate 382
urea 373
galactose 356
tyrosine 348
ACTH 318
noradrenaline 317
acetate 306
His 295
nitrogen 273
lysine 265
potassium 251
serine 225
glutamine 217
methionine 215
Phe 209
Adrenal 208
GTP 194
glutamate 193
ethanol 188
alloxan 181
Ile 178
Diabetol 178
NH2 161
threonine 161
sulfate 152
zinc 142
FFA 141
nitric oxide 140
tryptophan 138
ADP 137
isoleucine 135
tryptophan 135
ADP 134
ADP 134
cGMP 134
isoleucine 133
tryptophan 132
tryptophan 132
salt 126
creatinine 121
STZ 120
Secretin 117
5-HT 115
aldosterone 112
Gly 110
nicotinamide 109
Mg2+ 108
Asp 105
valine 105
prostaglandin E1 105
CO2 101
TSH 100
proline 97
ammonia 95
TNF 93
NAD 87
Cortisol 86
Metformin 86
Metformin 85
Cardiol 84
hydrogen 84
SDS 83
silver 81
Propranolol 80
Propranolol 79
PEG 78
Norepinephrine 77
CoA 71
adenylate 71
GABA 70
PGE2 70
cysteine 69
GABA 68
ammonium 65
NAD 63
barium 63
iron 62
TRH 62
Vasopressin 60
Dexamethasone 60
Glycogen 60
Sodium 59
caffeine 55
GDP 55
Lactate 55
EDTA 55
EDTA 55
NADH 53
palmitic acid 53
HCl 51
Isoproterenol 50
Alanine 50
acetic acid 50
GSH 50
GSH 50
manganese 49
Octreotide 48
ornithine 46
ornithine 46
ornithine 46
ornithine 46
ornithine 46
GMP 46
hexose 45
PEG 45
asparagine 45
iodine 45
COS 45
2-oxoglutarate 44
Theophylline 44
glutamic acid 44
gamma-aminobutyric acid 43
Forskolin 43
bromide 43
retinoic acid 41
TCA 40
nicotinic acid 40
Calcitonin 40
hexose 38
nicotinic acid 38
hexose 38
hexose 38
aspartic acid 37
acetyl-CoA 36
aldehyde 36
Fructose 36
aspartic acid 36
aspartic acid 36
aspartic acid 36
Thyroid 35
Angiotensin II 35
nicotinic acid 34
PMA 34
nicotinic acid 34
palmitic acid 33
Leucine 33
carbonate 33
Atropine 33
alpha-ketoisocaproate 32
TEM 31
more...