Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P01275 (
glucagon
)
26,492
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An increase of rat liver
glycerate kinase
[ATP: D-glycerate 2-phosphotransferase EC 2.7.1.31] on protein feeding, on starvation or during fetal and neonatal development was studied from the viewpoint of the role of
glucagon
as the mediator. On starvation and during fetal and neonatal development,
glycerate kinase
in the cytosolic and mitochondrial fractions increased approximately in the same ratio.
Glucagon
in plasma increased under these conditions and
glucagon
administration increased
glycerate kinase
in both intracellular fractions approximately in the same ratio. The above results suggested that
glucagon
functions as at least one of the mediators for these processes. In diabetic rats, only a slight increase of the enzyme in both intracellular fractions was observed. Protein feeding, however, strongly increased the mitochondrial enzyme.
Glucagon
failed to mediate this function of dietary protein for the mitochondrial enzyme.
...
PMID:Role of glucagon in increase of hepatic glycerate kinase of adult and neonatal rats. 630 63
